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Conserved domains on  [gi|557636661|ref|NP_001273528|]
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CLIP-associating protein 2 isoform d [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 168-198 2.31e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


:

Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.20  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 557636661  168 LVPHLCVLFGDSNSQVRNAALSAVVEIYRHV 198
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
CLASP_N super family cl20455
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 81-196 4.14e-03

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


The actual alignment was detected with superfamily member pfam12348:

Pssm-ID: 432496  Cd Length: 227  Bit Score: 38.34  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557636661   81 LSTRFKSYVTMVTTALIDRMGDVKDKVREEAqNLTLKLMDEVAP-PMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFG 159
Cdd:pfam12348  84 LGHHIDPMAEILLPTLLKLCGDTKKITSQNA-NQAVAAILSNASyTPRILQHISAASQDKNVQPREYSAIWLKILLRRHG 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557636661  160 TQPLVISK------LVPHLCVLFGDSNSQVRNAALSAVVEIYR 196
Cdd:pfam12348 163 HHKSHIEHsgglrlIEKSLKKGLEDANPGVRETARSTFWEFFK 205
 
Name Accession Description Interval E-value
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 168-198 2.31e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.20  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 557636661  168 LVPHLCVLFGDSNSQVRNAALSAVVEIYRHV 198
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 81-196 4.14e-03

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 38.34  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557636661   81 LSTRFKSYVTMVTTALIDRMGDVKDKVREEAqNLTLKLMDEVAP-PMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFG 159
Cdd:pfam12348  84 LGHHIDPMAEILLPTLLKLCGDTKKITSQNA-NQAVAAILSNASyTPRILQHISAASQDKNVQPREYSAIWLKILLRRHG 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557636661  160 TQPLVISK------LVPHLCVLFGDSNSQVRNAALSAVVEIYR 196
Cdd:pfam12348 163 HHKSHIEHsgglrlIEKSLKKGLEDANPGVRETARSTFWEFFK 205
 
Name Accession Description Interval E-value
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 168-198 2.31e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.20  E-value: 2.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 557636661  168 LVPHLCVLFGDSNSQVRNAALSAVVEIYRHV 198
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 81-196 4.14e-03

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 38.34  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557636661   81 LSTRFKSYVTMVTTALIDRMGDVKDKVREEAqNLTLKLMDEVAP-PMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFG 159
Cdd:pfam12348  84 LGHHIDPMAEILLPTLLKLCGDTKKITSQNA-NQAVAAILSNASyTPRILQHISAASQDKNVQPREYSAIWLKILLRRHG 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557636661  160 TQPLVISK------LVPHLCVLFGDSNSQVRNAALSAVVEIYR 196
Cdd:pfam12348 163 HHKSHIEHsgglrlIEKSLKKGLEDANPGVRETARSTFWEFFK 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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