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    PKNOX2 PBX/knotted 1 homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 63876, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PKNOX2provided by HGNC
    Official Full Name
    PBX/knotted 1 homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:16714
    See related
    Ensembl:ENSG00000165495 MIM:613066; AllianceGenome:HGNC:16714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PREP2
    Summary
    Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
    Expression
    Broad expression in thyroid (RPKM 4.8), ovary (RPKM 4.1) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PKNOX2 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125164751..125433389)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125193419..125462086)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (125034647..125303285)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 59 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125011687-125012243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125048979-125049726 Neighboring gene PKNOX2 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125049727-125050473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125084643-125085174 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:125094169-125094781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125098532-125099526 Neighboring gene PKNOX2 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 321, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125181994-125182578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125211245-125211994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125219321-125219863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125220519-125221182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125221183-125221844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125239164-125240045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125241808-125242687 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:125278650-125279849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125296399-125296900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125298605-125299508 Neighboring gene Sharpr-MPRA regulatory region 8813 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:125314964-125315827 Neighboring gene Sharpr-MPRA regulatory region 13231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:125364213-125364716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125365219-125365722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125365723-125366224 Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene putative uncharacterized protein MGC39545 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5907 Neighboring gene Sharpr-MPRA regulatory region 4861 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5909 Neighboring gene CRISPRi-validated cis-regulatory element chr11.5910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:125439037-125439538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5698 Neighboring gene STT3A antisense RNA 1 Neighboring gene RNA, U6 small nuclear 1156, pseudogene Neighboring gene EI24 autophagy associated transmembrane protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of human PKNOX2, a novel homeobox-containing gene. Imoto I, et al. Biochem Biophys Res Commun, 2001 Sep 14. PMID 11549286
    2. PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors. Cagnan I, et al. Mol Biol Rep, 2019 Feb. PMID 30515693
    3. The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women. Chen X, et al. PLoS One, 2011 Jan 27. PMID 21298047, Free PMC Article
    4. PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. Chen L, et al. Signal Transduct Target Ther, 2024 Apr 22. PMID 38644381, Free PMC Article
    5. Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. Fognani C, et al. Nucleic Acids Res, 2002 May 1. PMID 11972344, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.
      Title: PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.
    2. PKNOX2 is a tumor suppressor in gastric cancer by activation of IGFBP5 and p53 signaling pathways
      Title: PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53.
    3. PKNOX2 was significantly downregulated in Fanconi anemia cells compared to donors.
      Title: PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.
    4. We identified four new loci (PKNOX2, MYH13, PHF2, and GPC6) associated with formal thought disorder in schizophrenia.
      Title: PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
    5. Using data from several genomewide case-control studies, we identified a strong and significant association signal with a novel gene, PKNOX2, on chromosome 11 with the composite phenotype in European-origin women
      Title: The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. This novel PKNOX-related protein may interact with PBX proteins and play a role in tissue-specific regulation of transcription.
      Title: Identification and characterization of human PKNOX2, a novel homeobox-containing gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
    EBI GWAS Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.
    EBI GWAS Catalog
    Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
    EBI GWAS Catalog
    Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
    EBI GWAS Catalog
    The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13074

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein PKNOX2
    Names
    PBX/knotted homeobox 2
    homeobox protein PREP-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382323.2 → NP_001369252.1  homeobox protein PKNOX2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Consensus CDS
      CCDS41730.1
      UniProtKB/Swiss-Prot
      B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Related
      ENSP00000298282.8, ENST00000298282.14
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    2. NM_001382324.1 → NP_001369253.1  homeobox protein PKNOX2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Consensus CDS
      CCDS41730.1
      UniProtKB/Swiss-Prot
      B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    3. NM_001382325.1 → NP_001369254.1  homeobox protein PKNOX2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Consensus CDS
      CCDS41730.1
      UniProtKB/Swiss-Prot
      B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    4. NM_001382326.1 → NP_001369255.1  homeobox protein PKNOX2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Consensus CDS
      CCDS41730.1
      UniProtKB/Swiss-Prot
      B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    5. NM_001382327.1 → NP_001369256.1  homeobox protein PKNOX2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Consensus CDS
      CCDS41730.1
      UniProtKB/Swiss-Prot
      B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    6. NM_001382328.1 → NP_001369257.1  homeobox protein PKNOX2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Consensus CDS
      CCDS41730.1
      UniProtKB/Swiss-Prot
      B7Z5I5, F5GZ15, Q63HL6, Q86XD1, Q96KN3
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    7. NM_001382329.1 → NP_001369258.1  homeobox protein PKNOX2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 8-11, encodes isoform b.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6, B7ZAF3
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    8. NM_001382330.1 → NP_001369259.1  homeobox protein PKNOX2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 7 and 9-11, encodes isoform b.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6, B7ZAF3
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    9. NM_001382331.1 → NP_001369260.1  homeobox protein PKNOX2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 7, 8, 10, and 11, encodes isoform b.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6, B7ZAF3
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    10. NM_001382332.1 → NP_001369261.1  homeobox protein PKNOX2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 7-9 and 11, encodes isoform b.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6, B7ZAF3
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    11. NM_001382333.1 → NP_001369262.1  homeobox protein PKNOX2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 7-10, encodes isoform b.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6, B7ZAF3
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    12. NM_001382334.1 → NP_001369263.1  homeobox protein PKNOX2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variant 13, encodes isoform c.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Conserved Domains (3) summary
      pfam05920
      Location:194 → 229
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    13. NM_001382335.1 → NP_001369264.1  homeobox protein PKNOX2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variant 12, encodes isoform c.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Conserved Domains (3) summary
      pfam05920
      Location:194 → 229
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    14. NM_001382336.1 → NP_001369265.1  homeobox protein PKNOX2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform d.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Conserved Domains (2) summary
      pfam05920
      Location:165 → 200
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    15. NM_001382337.1 → NP_001369266.1  homeobox protein PKNOX2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform d.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Conserved Domains (2) summary
      pfam05920
      Location:165 → 200
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    16. NM_001382338.1 → NP_001369267.1  homeobox protein PKNOX2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform d.
      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      Conserved Domains (2) summary
      pfam05920
      Location:165 → 200
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:67 → 152
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    17. NM_001382339.1 → NP_001369268.1  homeobox protein PKNOX2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (3) summary
      pfam05920
      Location:302 → 341
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    18. NM_001382340.1 → NP_001369269.1  homeobox protein PKNOX2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (2) summary
      pfam05920
      Location:242 → 281
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:32 → 117
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    19. NM_001382341.1 → NP_001369270.1  homeobox protein PKNOX2 isoform g

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069
      UniProtKB/TrEMBL
      B7Z3G7, B7Z9N6
      Conserved Domains (3) summary
      pfam05920
      Location:230 → 269
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    RNA

    1. NR_168076.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    2. NR_168077.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    3. NR_168078.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    4. NR_168079.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    5. NR_168080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    6. NR_168081.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    7. NR_168082.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    8. NR_168083.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    9. NR_168084.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000708, AP001007, AP003061, AP003069

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      125164751..125433389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      125193419..125462086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022062.3: Suppressed sequence

      Description
      NM_022062.3: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96KN3.2 GenPept UniProtKB/Swiss-Prot:Q96KN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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