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Conserved domains on  [gi|1835922474|ref|NP_001369270|]
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homeobox protein PKNOX2 isoform g [Homo sapiens]

Protein Classification

homeobox protein( domain architecture ID 11243274)

homeobox protein is involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 96-181 3.29e-51

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


:

Pssm-ID: 465140  Cd Length: 86  Bit Score: 166.37  E-value: 3.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922474  96 GSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNL 175
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIERAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 1835922474 176 LRNDLG 181
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 231-269 7.10e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 81.79  E-value: 7.10e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1835922474 231 LFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
PLN02983 super family cl33616
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-66 1.19e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


The actual alignment was detected with superfamily member PLN02983:

Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.21  E-value: 1.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835922474   3 QHASPAPALTMMatqnvPPPPYQDSPQMTATAQPpskaqavhisAPSAAASTPVPSAPIDPQAQ 66
Cdd:PLN02983  143 QPPPPAPVVMMQ-----PPPPHAMPPASPPAAQP----------APSAPASSPPPTPASPPPAK 191
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 96-181 3.29e-51

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 166.37  E-value: 3.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922474  96 GSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNL 175
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIERAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 1835922474 176 LRNDLG 181
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 231-269 7.10e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 81.79  E-value: 7.10e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1835922474 231 LFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 212-269 1.58e-13

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 64.58  E-value: 1.58e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1835922474  212 SKNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKE-FQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 213-269 1.65e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 64.57  E-value: 1.65e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835922474 213 KNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:cd00086     1 RRKRTRFTPEQLEELEKE-FEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-66 1.19e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.21  E-value: 1.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835922474   3 QHASPAPALTMMatqnvPPPPYQDSPQMTATAQPpskaqavhisAPSAAASTPVPSAPIDPQAQ 66
Cdd:PLN02983  143 QPPPPAPVVMMQ-----PPPPHAMPPASPPAAQP----------APSAPASSPPPTPASPPPAK 191
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 1-132 6.04e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 38.92  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922474   1 MMQHASPAPALTMMATQNVPPppYQDSPQMTATAQPPSKAQAVHISAPSaAASTPvpsapidPQAQLEADKrAVYRHPLF 80
Cdd:PRK08691  415 MPSEGKTAGPVSNQENNDVPP--WEDAPDEAQTAAGTAQTSAKSIQTAS-EAETP-------PENQVSKNK-AADNETDA 483

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835922474  81 PLLTLLFEKCEQATQGSECitsasfdVDIENFVHQQEQEHKPFFS----DDPELDN 132
Cdd:PRK08691  484 PLSEVPSENPIQATPNDEA-------VETETFAHEAPAEPFYGYGfpdnDCPPEDG 532
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 96-181 3.29e-51

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 166.37  E-value: 3.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922474  96 GSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNL 175
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIERAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 1835922474 176 LRNDLG 181
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 231-269 7.10e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 81.79  E-value: 7.10e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1835922474 231 LFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 212-269 1.58e-13

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 64.58  E-value: 1.58e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1835922474  212 SKNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKE-FQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 213-269 1.65e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 64.57  E-value: 1.65e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835922474 213 KNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:cd00086     1 RRKRTRFTPEQLEELEKE-FEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
Homeodomain pfam00046
Homeodomain;
231-269 4.27e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.64  E-value: 4.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1835922474 231 LFQhlMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 269
Cdd:pfam00046  18 EFQ--ENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-66 1.19e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.21  E-value: 1.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835922474   3 QHASPAPALTMMatqnvPPPPYQDSPQMTATAQPpskaqavhisAPSAAASTPVPSAPIDPQAQ 66
Cdd:PLN02983  143 QPPPPAPVVMMQ-----PPPPHAMPPASPPAAQP----------APSAPASSPPPTPASPPPAK 191
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 1-132 6.04e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 38.92  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922474   1 MMQHASPAPALTMMATQNVPPppYQDSPQMTATAQPPSKAQAVHISAPSaAASTPvpsapidPQAQLEADKrAVYRHPLF 80
Cdd:PRK08691  415 MPSEGKTAGPVSNQENNDVPP--WEDAPDEAQTAAGTAQTSAKSIQTAS-EAETP-------PENQVSKNK-AADNETDA 483

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835922474  81 PLLTLLFEKCEQATQGSECitsasfdVDIENFVHQQEQEHKPFFS----DDPELDN 132
Cdd:PRK08691  484 PLSEVPSENPIQATPNDEA-------VETETFAHEAPAEPFYGYGfpdnDCPPEDG 532
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
4-75 6.91e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 38.08  E-value: 6.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835922474   4 HASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQaVHISAPSAAASTP------VPSAPIDPQAQLE-----ADKR 72
Cdd:PRK13042   29 NATTPSSTKVEAPQSTPPSTKVEAPQSKPNATTPPSTK-VEAPQQTPNATTPsstkveTPQSPTTKQVPTEinpkfKDLR 107


                  ...
gi 1835922474  73 AVY 75
Cdd:PRK13042  108 AYY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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