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    H2BC18 H2B clustered histone 18 [ Homo sapiens (human) ]

    Gene ID: 440689, updated on 14-Nov-2024

    Summary

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    Official Symbol
    H2BC18provided by HGNC
    Official Full Name
    H2B clustered histone 18provided by HGNC
    Primary source
    HGNC:HGNC:24700
    See related
    Ensembl:ENSG00000203814 AllianceGenome:HGNC:24700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIST2H2BF
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in prostate (RPKM 4.3), appendix (RPKM 1.9) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See H2BC18 in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149782689..149812370, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148906835..148936505, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149754245..149783925, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371406 Neighboring gene ubiquitin conjugating enzyme E2 D4 (putative) pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 8-1 Neighboring gene MPRA-validated peak406 silencer Neighboring gene uncharacterized LOC124904411 Neighboring gene Fc gamma receptor Ia Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149764669-149765433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1654 Neighboring gene H3 clustered histone 13 Neighboring gene H4 clustered histone 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibition of core histones acetylation by carcinogenic nickel(II). Golebiowski F, et al. Mol Cell Biochem, 2005 Nov. PMID 16283522
    2. KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1. Liu W, et al. Theranostics, 2021. PMID 33995658, Free PMC Article
    3. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Pavri R, et al. Cell, 2006 May 19. PMID 16713563
    4. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cheung WL, et al. Cell, 2003 May 16. PMID 12757711
    5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Zhu B, et al. Mol Cell, 2005 Nov 23. PMID 16307923

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, histone cluster 2, H2bf (HIST2H2BF), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35099, FLJ56780, FLJ56787, MGC131639

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    histone H2B type 2-F
    Names
    histone cluster 2 H2B family member f
    histone cluster 2, H2bf

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033089.2 RefSeqGene

      Range
      5000..5491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024599.5 → NP_001019770.1  histone H2B type 2-F isoform a

      See identical proteins and their annotated locations for NP_001019770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' coding region and 3' UTR, compared to variant 2. The encoded isoform (a) has a shorter C-terminus compared to isoform b.
      Source sequence(s)
      AC239868
      Consensus CDS
      CCDS30846.1
      UniProtKB/Swiss-Prot
      A8K0U9, B4DLA9, Q5QNW6
      UniProtKB/TrEMBL
      Q0D2M2
      Related
      ENSP00000358164.1, ENST00000369167.3
      Conserved Domains (1) summary
      smart00427
      Location:28 → 124
      H2B; Histone H2B

    2. NM_001161334.2 → NP_001154806.1  histone H2B type 2-F isoform b

      See identical proteins and their annotated locations for NP_001154806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (b)
      Source sequence(s)
      AK296916
      Consensus CDS
      CCDS53359.1
      UniProtKB/TrEMBL
      Q0D2M2
      Related
      ENSP00000445831.1, ENST00000545683.1
      Conserved Domains (1) summary
      smart00427
      Location:28 → 124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      149782689..149812370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      148906835..148936505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5QNW6.3 GenPept UniProtKB/Swiss-Prot:Q5QNW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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