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    PTK2 protein tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 5747, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PTK2provided by HGNC
    Official Full Name
    protein tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:9611
    See related
    Ensembl:ENSG00000169398 MIM:600758; AllianceGenome:HGNC:9611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAK; FADK; FAK1; FRNK; FADK 1; PPP1R71; p125FAK; pp125FAK
    Summary
    This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

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    See PTK2 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (140657900..141002079, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (141777902..142122150, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141667999..142012178, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene argonaute RISC catalytic component 2 Neighboring gene MAGE-like protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141634221-141635220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141635221-141636221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141640637-141641137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643203-141643970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643971-141644737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19583 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:141655407-141656606 Neighboring gene uncharacterized LOC124902099 Neighboring gene E2F1-regulated inhibitor of cell death Neighboring gene microRNA 151a Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:141901324-141901954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:141901955-141902583 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141903275-141903488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141959143-141960131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28038 Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene Sharpr-MPRA regulatory region 10587 Neighboring gene NANOG hESC enhancer GRCh37_chr8:141986399-141986923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142026737-142027298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142030905-142031616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142032328-142033038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142033039-142033749 Neighboring gene uncharacterized LOC105375783 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899 Neighboring gene uncharacterized LOC124902030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047320-142047944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047945-142048570

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibition of cell migration by focal adhesion kinase: Time-dependent difference in integrin-induced signaling between endothelial and hepatoblastoma cells. Yu H, et al. Int J Mol Med, 2018 May. PMID 29484384, Free PMC Article
    2. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. Kang Y, et al. J Natl Cancer Inst, 2013 Oct 2. PMID 24062525, Free PMC Article
    3. Focal adhesion kinase activation limits efficacy of Dasatinib in c-Myc driven hepatocellular carcinoma. Liu X, et al. Cancer Med, 2018 Dec. PMID 30370649, Free PMC Article
    4. FAK alleviates radiation-induced rectal injury by decreasing apoptosis. Li JJ, et al. Toxicol Appl Pharmacol, 2018 Dec 1. PMID 30292832
    5. Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase. Fu XD, et al. Endocr Relat Cancer, 2010 Jun. PMID 20233709

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway.
      Title: DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway.
    2. Inhibition of Integrin-Associated Kinases FAK and ILK on the In Vitro Model of Skin Wound Healing.
      Title: Inhibition of Integrin-Associated Kinases FAK and ILK on the In Vitro Model of Skin Wound Healing.
    3. Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.
      Title: Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.
    4. Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1.
      Title: Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1.
    5. Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.
      Title: Analysis of Expression of the ANG1, CaSR and FAK Proteins in Uterine Fibroids.
    6. Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk.
      Title: Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk.
    7. FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro.
      Title: FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro.
    8. FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity.
      Title: FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity.
    9. T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway.
      Title: T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway.
    10. The dysadherin/FAK axis promotes individual cell migration in colon cancer.
      Title: The dysadherin/FAK axis promotes individual cell migration in colon cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (790)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-stimulated cells overexpressing NHERF1 upregulates FAK phosphorylation PubMed
    env Focal adhesion kinase (FAK), CD4, and HIV-1 gp120 co-localize in T cells. The formation of FAK-CD4 complex is induced by gp120 PubMed
    Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
    tat Focal adhesion kinase (FAK) is tyrosine-phosphorylated by Tat, and inhibition of FAK by the dominant interfering mutant form, FAK-related nonkinase, significantly blocks HBMEC migration and disrupted focal adhesions upon Tat activation PubMed
    tat HIV-1 Tat upregulates p125FAK and induces the tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 neuronal cells PubMed
    tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular function activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
    		  
    involved_in angiogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell motility TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of muscle stretch TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heart morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in netrin-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in placenta development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of epithelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of positive regulation of macrophage chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of macrophage proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of epithelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of focal adhesion assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of focal adhesion assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of substrate adhesion-dependent cell spreading IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    focal adhesion kinase 1
    Names
    FAK-related non-kinase polypeptide
    PTK2 protein tyrosine kinase 2
    focal adhesion kinase-related nonkinase
    protein phosphatase 1 regulatory subunit 71
    NP_001186578.1
    NP_001303271.1
    NP_001339623.1
    NP_001339624.1
    NP_001339625.1
    NP_001339626.1
    NP_001339627.1
    NP_001339628.1
    NP_001339629.1
    NP_001339630.1
    NP_001339631.1
    NP_001339632.1
    NP_001339633.1
    NP_001339634.1
    NP_001339635.1
    NP_001339636.1
    NP_001339637.1
    NP_001339638.1
    NP_001339639.1
    NP_001339640.1
    NP_001339641.1
    NP_001339642.1
    NP_001339643.1
    NP_001339644.1
    NP_001339645.1
    NP_001339646.1
    NP_001339647.1
    NP_001339648.1
    NP_001339649.1
    NP_001339650.1
    NP_001339651.1
    NP_001339652.1
    NP_001339653.1
    NP_001339654.1
    NP_001339655.1
    NP_001339656.1
    NP_001339657.1
    NP_001339658.1
    NP_001339659.1
    NP_001339660.1
    NP_001339661.1
    NP_001339662.1
    NP_001339663.1
    NP_001339664.1
    NP_001339665.1
    NP_001339666.1
    NP_001339667.1
    NP_001339668.1
    NP_001339669.1
    NP_001339670.1
    NP_001339671.1
    NP_001339672.1
    NP_001339673.1
    NP_001339674.1
    NP_001339675.1
    NP_001339676.1
    NP_001339677.1
    NP_001339678.1
    NP_001339679.1
    NP_001339680.1
    NP_001339681.1
    NP_001374513.1
    NP_001374514.1
    NP_001374515.1
    NP_001374516.1
    NP_001374517.1
    NP_001374518.1
    NP_001374519.1
    NP_001374520.1
    NP_001374521.1
    NP_001374532.1
    NP_001374533.1
    NP_001374534.1
    NP_001374535.1
    NP_001374536.1
    NP_001374537.1
    NP_001374538.1
    NP_001374539.1
    NP_001374540.1
    NP_001374541.1
    NP_001374542.1
    NP_001374543.1
    NP_001374544.1
    NP_001374545.1
    NP_001374546.1
    NP_001374547.1
    NP_001374548.1
    NP_001374549.1
    NP_001374550.1
    NP_001374551.1
    NP_001374552.1
    NP_001374553.1
    NP_001374554.1
    NP_001374556.1
    NP_001374557.1
    NP_001374558.1
    NP_001374559.1
    NP_001374560.1
    NP_001374561.1
    NP_001374562.1
    NP_001374563.1
    NP_001374564.1
    NP_001374565.1
    NP_001374566.1
    NP_001374567.1
    NP_001374568.1
    NP_001374569.1
    NP_001374570.1
    NP_001374571.1
    NP_001374572.1
    NP_001374573.1
    NP_001374574.1
    NP_001374575.1
    NP_001374576.1
    NP_001374577.1
    NP_001374578.1
    NP_001374579.1
    NP_001374580.1
    NP_001374581.1
    NP_001374582.1
    NP_001374583.1
    NP_001374584.1
    NP_001374585.1
    NP_001374586.1
    NP_001374587.1
    NP_001374588.1
    NP_001374589.1
    NP_001374590.1
    NP_001374591.1
    NP_005598.3
    NP_722560.1
    XP_024302970.1
    XP_024302971.1
    XP_024302975.1
    XP_024302976.1
    XP_024302977.1
    XP_047277972.1
    XP_047277973.1
    XP_047277974.1
    XP_047277975.1
    XP_047277976.1
    XP_047277977.1
    XP_047277978.1
    XP_047277979.1
    XP_047277980.1
    XP_047277981.1
    XP_047277982.1
    XP_047277983.1
    XP_047277984.1
    XP_047277985.1
    XP_047277986.1
    XP_047277987.1
    XP_047277988.1
    XP_047277989.1
    XP_047277990.1
    XP_047277991.1
    XP_047277992.1
    XP_047277993.1
    XP_047277994.1
    XP_047277995.1
    XP_047277996.1
    XP_047277997.1
    XP_047277999.1
    XP_047278000.1
    XP_047278001.1
    XP_047278002.1
    XP_047278003.1
    XP_047278004.1
    XP_047278005.1
    XP_047278006.1
    XP_047278008.1
    XP_047278009.1
    XP_047278010.1
    XP_054216858.1
    XP_054216859.1
    XP_054216860.1
    XP_054216861.1
    XP_054216862.1
    XP_054216863.1
    XP_054216864.1
    XP_054216865.1
    XP_054216866.1
    XP_054216867.1
    XP_054216868.1
    XP_054216869.1
    XP_054216870.1
    XP_054216871.1
    XP_054216872.1
    XP_054216873.1
    XP_054216874.1
    XP_054216875.1
    XP_054216876.1
    XP_054216877.1
    XP_054216878.1
    XP_054216879.1
    XP_054216880.1
    XP_054216881.1
    XP_054216882.1
    XP_054216883.1
    XP_054216884.1
    XP_054216885.1
    XP_054216886.1
    XP_054216887.1
    XP_054216888.1
    XP_054216889.1
    XP_054216890.1
    XP_054216891.1
    XP_054216892.1
    XP_054216893.1
    XP_054216894.1
    XP_054216895.1
    XP_054216896.1
    XP_054216897.1
    XP_054216898.1
    XP_054216899.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029467.2 RefSeqGene

      Range
      5032..348414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199649.2 → NP_001186578.1  focal adhesion kinase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, and contains two additional in-frame segments near the 3' end of the coding sequence, compared to variant 2. The resulting isoform (c) is shorter at the N-terminus and contains two additional segments in the C-terminus compared to isoform b.
      Source sequence(s)
      AB209083, AC067931, AK304356, AL832961, BF434494, DA236314, DA994616
      Consensus CDS
      CCDS56557.1
      UniProtKB/TrEMBL
      A0A059VC25
      Related
      ENSP00000341189.3, ENST00000340930.7
      Conserved Domains (6) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143 → 248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:929 → 1058
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:422 → 676
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_001316342.2 → NP_001303271.1  focal adhesion kinase 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons and contains two other alternate in-frame exons compared to variant 2. The resulting isoform (d) differs in the 5' UTR, has a shorter and distinct N-terminus, and contains two alternative segments compared to isoform b. Variants 4 and 7 both encode the same isoform (d).
      Source sequence(s)
      AB209071, AC067931, BF434494, BY800117
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315 → 584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819 → 948
      Focal_AT; Focal adhesion targeting region

    3. NM_001352694.2 → NP_001339623.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 1, encodes isoform a.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    4. NM_001352695.2 → NP_001339624.1  focal adhesion kinase 1 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:449 → 718
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:929 → 1058
      Focal_AT; Focal adhesion targeting region

    5. NM_001352696.2 → NP_001339625.1  focal adhesion kinase 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 4, encodes isoform d.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315 → 584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819 → 948
      Focal_AT; Focal adhesion targeting region

    6. NM_001352697.2 → NP_001339626.1  focal adhesion kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:500 → 769
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:980 → 1109
      Focal_AT; Focal adhesion targeting region

    7. NM_001352698.2 → NP_001339627.1  focal adhesion kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:469 → 738
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49 → 271
      B41; Band 4.1 homologues
      cd13190
      Location:267 → 377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:973 → 1102
      Focal_AT; Focal adhesion targeting region

    8. NM_001352699.2 → NP_001339628.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 11-14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94346.1
      UniProtKB/TrEMBL
      A0A059VC25, A0A8Q3WLM4
      Conserved Domains (4) summary
      cd05056
      Location:456 → 725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region

    9. NM_001352700.2 → NP_001339629.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 10 and 12-14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94346.1
      UniProtKB/TrEMBL
      A0A059VC25, A0A8Q3WLM4
      Conserved Domains (4) summary
      cd05056
      Location:456 → 725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region

    10. NM_001352701.2 → NP_001339630.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 10, 11, 13, and 14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94346.1
      UniProtKB/TrEMBL
      A0A059VC25, A0A8Q3WLM4
      Conserved Domains (4) summary
      cd05056
      Location:456 → 725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region

    11. NM_001352702.2 → NP_001339631.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 10-12 and 14, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94346.1
      UniProtKB/TrEMBL
      A0A059VC25, A0A8Q3WLM4
      Related
      ENSP00000512868.1, ENST00000696786.1
      Conserved Domains (4) summary
      cd05056
      Location:456 → 725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region

    12. NM_001352703.2 → NP_001339632.1  focal adhesion kinase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 10-13, encodes isoform g.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94346.1
      UniProtKB/TrEMBL
      A0A059VC25, A0A8Q3WLM4
      Conserved Domains (4) summary
      cd05056
      Location:456 → 725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region

    13. NM_001352704.2 → NP_001339633.1  focal adhesion kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:449 → 718
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:953 → 1082
      Focal_AT; Focal adhesion targeting region

    14. NM_001352705.2 → NP_001339634.1  focal adhesion kinase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:441 → 710
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49 → 271
      B41; Band 4.1 homologues
      cd13190
      Location:267 → 377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:945 → 1074
      Focal_AT; Focal adhesion targeting region

    15. NM_001352706.2 → NP_001339635.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 18-21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:932 → 1061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    16. NM_001352707.2 → NP_001339636.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 17 and 19-21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:932 → 1061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    17. NM_001352708.2 → NP_001339637.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 17,18, 20, and 21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:932 → 1061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    18. NM_001352709.2 → NP_001339638.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 17-19 and 21, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:932 → 1061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    19. NM_001352710.2 → NP_001339639.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 17-20, encodes isoform j.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:932 → 1061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    20. NM_001352711.2 → NP_001339640.1  focal adhesion kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:427 → 696
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:931 → 1060
      Focal_AT; Focal adhesion targeting region

    21. NM_001352712.2 → NP_001339641.1  focal adhesion kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:456 → 725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:957 → 1086
      Focal_AT; Focal adhesion targeting region

    22. NM_001352713.2 → NP_001339642.1  focal adhesion kinase 1 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform m.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:422 → 691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:926 → 1055
      Focal_AT; Focal adhesion targeting region

    23. NM_001352714.2 → NP_001339643.1  focal adhesion kinase 1 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform m.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:422 → 691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:926 → 1055
      Focal_AT; Focal adhesion targeting region

    24. NM_001352715.2 → NP_001339644.1  focal adhesion kinase 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:421 → 690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:925 → 1054
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    25. NM_001352716.2 → NP_001339645.1  focal adhesion kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:420 → 689
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:924 → 1053
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    26. NM_001352717.2 → NP_001339646.1  focal adhesion kinase 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:421 → 690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:922 → 1051
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    27. NM_001352718.2 → NP_001339647.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:919 → 1048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    28. NM_001352719.2 → NP_001339648.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:919 → 1048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    29. NM_001352720.2 → NP_001339649.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform q.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:919 → 1048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    30. NM_001352721.2 → NP_001339650.1  focal adhesion kinase 1 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 33 and 34, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:911 → 1040
      Focal_AT; Focal adhesion targeting region

    31. NM_001352722.2 → NP_001339651.1  focal adhesion kinase 1 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 32 and 34, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:911 → 1040
      Focal_AT; Focal adhesion targeting region

    32. NM_001352723.2 → NP_001339652.1  focal adhesion kinase 1 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variants 32 and 33, encodes isoform r.
      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:911 → 1040
      Focal_AT; Focal adhesion targeting region

    33. NM_001352724.2 → NP_001339653.1  focal adhesion kinase 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:932 → 1034
      Focal_AT; Focal adhesion targeting region

    34. NM_001352725.2 → NP_001339654.1  focal adhesion kinase 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:898 → 1027
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    35. NM_001352726.2 → NP_001339655.1  focal adhesion kinase 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:392 → 661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:896 → 1025
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    36. NM_001352727.2 → NP_001339656.1  focal adhesion kinase 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:911 → 1013
      Focal_AT; Focal adhesion targeting region

    37. NM_001352728.2 → NP_001339657.1  focal adhesion kinase 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:379 → 648
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:880 → 1009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    38. NM_001352729.2 → NP_001339658.1  focal adhesion kinase 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:392 → 661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:875 → 1004
      Focal_AT; Focal adhesion targeting region

    39. NM_001352730.2 → NP_001339659.1  focal adhesion kinase 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GM6
      Conserved Domains (4) summary
      cd05056
      Location:343 → 612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:847 → 976
      Focal_AT; Focal adhesion targeting region

    40. NM_001352731.2 → NP_001339660.1  focal adhesion kinase 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GM6
      Conserved Domains (4) summary
      cd05056
      Location:343 → 612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:845 → 974
      Focal_AT; Focal adhesion targeting region

    41. NM_001352732.2 → NP_001339661.1  focal adhesion kinase 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GM6
      Conserved Domains (4) summary
      cd05056
      Location:343 → 612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:844 → 973
      Focal_AT; Focal adhesion targeting region

    42. NM_001352733.2 → NP_001339662.1  focal adhesion kinase 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GM6
      Conserved Domains (4) summary
      cd05056
      Location:336 → 605
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:840 → 969
      Focal_AT; Focal adhesion targeting region

    43. NM_001352734.2 → NP_001339663.1  focal adhesion kinase 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GM6
      Conserved Domains (4) summary
      cd05056
      Location:343 → 612
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:826 → 955
      Focal_AT; Focal adhesion targeting region

    44. NM_001352735.2 → NP_001339664.1  focal adhesion kinase 1 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GM6
      Conserved Domains (4) summary
      cd05056
      Location:322 → 591
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 124
      B41; Band 4.1 homologues
      cd13190
      Location:120 → 230
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:826 → 955
      Focal_AT; Focal adhesion targeting region

    45. NM_001352736.2 → NP_001339665.1  focal adhesion kinase 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:320 → 589
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:16 → 157
      B41; Band 4.1 homologues
      cd13190
      Location:153 → 263
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:824 → 953
      Focal_AT; Focal adhesion targeting region

    46. NM_001352737.2 → NP_001339666.1  focal adhesion kinase 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GM6
      Conserved Domains (4) summary
      cd05056
      Location:336 → 605
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:837 → 966
      Focal_AT; Focal adhesion targeting region

    47. NM_001352738.2 → NP_001339667.1  focal adhesion kinase 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315 → 584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:817 → 946
      Focal_AT; Focal adhesion targeting region

    48. NM_001352739.2 → NP_001339668.1  focal adhesion kinase 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:309 → 578
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:813 → 942
      Focal_AT; Focal adhesion targeting region

    49. NM_001352740.2 → NP_001339669.1  focal adhesion kinase 1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (3) summary
      cd05056
      Location:308 → 577
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

    50. NM_001352741.2 → NP_001339670.1  focal adhesion kinase 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806 → 935
      Focal_AT; Focal adhesion targeting region

    51. NM_001352742.2 → NP_001339671.1  focal adhesion kinase 1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:294 → 563
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 124
      B41; Band 4.1 homologues
      cd13190
      Location:120 → 230
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:798 → 927
      Focal_AT; Focal adhesion targeting region

    52. NM_001352743.2 → NP_001339672.1  focal adhesion kinase 1 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315 → 584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:798 → 927
      Focal_AT; Focal adhesion targeting region

    53. NM_001352744.2 → NP_001339673.1  focal adhesion kinase 1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:279 → 548
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:783 → 912
      Focal_AT; Focal adhesion targeting region

    54. NM_001352745.2 → NP_001339674.1  focal adhesion kinase 1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:273 → 542
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:777 → 906
      Focal_AT; Focal adhesion targeting region

    55. NM_001352746.2 → NP_001339675.1  focal adhesion kinase 1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:258 → 527
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 124
      B41; Band 4.1 homologues
      cd13190
      Location:120 → 194
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:762 → 891
      Focal_AT; Focal adhesion targeting region

    56. NM_001352747.2 → NP_001339676.1  focal adhesion kinase 1 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      E9PEI4
      Conserved Domains (2) summary
      pfam03623
      Location:445 → 574
      Focal_AT; Focal adhesion targeting region
      cl21453
      Location:1 → 210
      PKc_like; Protein Kinases, catalytic domain

    57. NM_001352748.2 → NP_001339677.1  focal adhesion kinase 1 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009, AC105235
      Conserved Domains (3) summary
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cl21453
      Location:428 → 496
      PKc_like; Protein Kinases, catalytic domain

    58. NM_001352749.2 → NP_001339678.1  focal adhesion kinase 1 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:229 → 358
      Focal_AT; Focal adhesion targeting region

    59. NM_001352750.2 → NP_001339679.1  focal adhesion kinase 1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Consensus CDS
      CCDS87628.1
      UniProtKB/TrEMBL
      B4DWJ1
      Related
      ENSP00000403416.2, ENST00000430260.6
      Conserved Domains (1) summary
      pfam03623
      Location:226 → 355
      Focal_AT; Focal adhesion targeting region

    60. NM_001352751.2 → NP_001339680.1  focal adhesion kinase 1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:208 → 337
      Focal_AT; Focal adhesion targeting region

    61. NM_001352752.2 → NP_001339681.1  focal adhesion kinase 1 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC067931
      Conserved Domains (1) summary
      pfam03623
      Location:205 → 334
      Focal_AT; Focal adhesion targeting region

    62. NM_001387584.1 → NP_001374513.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    63. NM_001387585.1 → NP_001374514.1  focal adhesion kinase 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:895 → 1024
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    64. NM_001387586.1 → NP_001374515.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Related
      ENSP00000429929.1, ENST00000519654.5
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    65. NM_001387587.1 → NP_001374516.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    66. NM_001387588.1 → NP_001374517.1  focal adhesion kinase 1 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009
      Consensus CDS
      CCDS94345.1
      UniProtKB/TrEMBL
      E5RFW9, E5RI72
      Related
      ENSP00000430044.1, ENST00000520045.5
      Conserved Domains (1) summary
      pfam18038
      Location:35 → 121
      FERM_N_2; FERM N-terminal domain

    67. NM_001387589.1 → NP_001374518.1  focal adhesion kinase 1 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009
      UniProtKB/TrEMBL
      E5RI72
      Conserved Domains (1) summary
      pfam18038
      Location:48 → 134
      FERM_N_2; FERM N-terminal domain

    68. NM_001387590.1 → NP_001374519.1  focal adhesion kinase 1 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:266 → 535
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:767 → 896
      Focal_AT; Focal adhesion targeting region

    69. NM_001387591.1 → NP_001374520.1  focal adhesion kinase 1 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:782 → 911
      Focal_AT; Focal adhesion targeting region

    70. NM_001387592.1 → NP_001374521.1  focal adhesion kinase 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      H0YB16
      Related
      ENSP00000428492.1, ENST00000523539.5
      Conserved Domains (3) summary
      cd05056
      Location:101 → 370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602 → 731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    71. NM_001387603.1 → NP_001374532.1  focal adhesion kinase 1 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:785 → 914
      Focal_AT; Focal adhesion targeting region

    72. NM_001387604.1 → NP_001374533.1  focal adhesion kinase 1 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      H0YB16
      Conserved Domains (3) summary
      cd05056
      Location:101 → 370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:605 → 734
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    73. NM_001387605.1 → NP_001374534.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    74. NM_001387606.1 → NP_001374535.1  focal adhesion kinase 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:309 → 578
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:813 → 942
      Focal_AT; Focal adhesion targeting region

    75. NM_001387607.1 → NP_001374536.1  focal adhesion kinase 1 isoform 58

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315 → 584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:816 → 945
      Focal_AT; Focal adhesion targeting region

    76. NM_001387608.1 → NP_001374537.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    77. NM_001387609.1 → NP_001374538.1  focal adhesion kinase 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806 → 935
      Focal_AT; Focal adhesion targeting region

    78. NM_001387610.1 → NP_001374539.1  focal adhesion kinase 1 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:241 → 510
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:18 → 84
      B41; Band 4.1 homologues
      cd13190
      Location:80 → 190
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:742 → 871
      Focal_AT; Focal adhesion targeting region

    79. NM_001387611.1 → NP_001374540.1  focal adhesion kinase 1 isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:308 → 577
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:809 → 938
      Focal_AT; Focal adhesion targeting region

    80. NM_001387612.1 → NP_001374541.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    81. NM_001387613.1 → NP_001374542.1  focal adhesion kinase 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:806 → 935
      Focal_AT; Focal adhesion targeting region

    82. NM_001387614.1 → NP_001374543.1  focal adhesion kinase 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:895 → 1024
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    83. NM_001387615.1 → NP_001374544.1  focal adhesion kinase 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:392 → 661
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:896 → 1025
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    84. NM_001387616.1 → NP_001374545.1  focal adhesion kinase 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      H0YB16
      Conserved Domains (3) summary
      cd05056
      Location:101 → 370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602 → 731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    85. NM_001387617.1 → NP_001374546.1  focal adhesion kinase 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      H0YB16
      Conserved Domains (3) summary
      cd05056
      Location:101 → 370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602 → 731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    86. NM_001387618.1 → NP_001374547.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    87. NM_001387619.1 → NP_001374548.1  focal adhesion kinase 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:379 → 648
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:880 → 1009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    88. NM_001387620.1 → NP_001374549.1  focal adhesion kinase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:315 → 584
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:819 → 948
      Focal_AT; Focal adhesion targeting region

    89. NM_001387621.1 → NP_001374550.1  focal adhesion kinase 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      H0YB16
      Conserved Domains (3) summary
      cd05056
      Location:101 → 370
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:602 → 731
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    90. NM_001387622.1 → NP_001374551.1  focal adhesion kinase 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:421 → 690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:922 → 1051
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    91. NM_001387623.1 → NP_001374552.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    92. NM_001387624.1 → NP_001374553.1  focal adhesion kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:420 → 689
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:924 → 1053
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    93. NM_001387625.1 → NP_001374554.1  focal adhesion kinase 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:898 → 1027
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    94. NM_001387627.1 → NP_001374556.1  focal adhesion kinase 1 isoform 60

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:421 → 690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:901 → 1030
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    95. NM_001387628.1 → NP_001374557.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Related
      ENSP00000429474.1, ENST00000521059.5
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    96. NM_001387629.1 → NP_001374558.1  focal adhesion kinase 1 isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      H0YB16
      Related
      ENSP00000430603.1, ENST00000521986.5
      Conserved Domains (3) summary
      cd05056
      Location:107 → 376
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      pfam03623
      Location:611 → 740
      Focal_AT; Focal adhesion targeting region
      cl17171
      Location:1 → 50
      PH-like; Pleckstrin homology-like domain

    97. NM_001387630.1 → NP_001374559.1  focal adhesion kinase 1 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:241 → 510
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:18 → 84
      B41; Band 4.1 homologues
      cd13190
      Location:80 → 190
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:742 → 871
      Focal_AT; Focal adhesion targeting region

    98. NM_001387631.1 → NP_001374560.1  focal adhesion kinase 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:420 → 689
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:924 → 1053
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    99. NM_001387632.1 → NP_001374561.1  focal adhesion kinase 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:895 → 1024
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    100. NM_001387633.1 → NP_001374562.1  focal adhesion kinase 1 isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:422 → 691
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:905 → 1034
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    101. NM_001387634.1 → NP_001374563.1  focal adhesion kinase 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:421 → 690
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:925 → 1054
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    102. NM_001387635.1 → NP_001374564.1  focal adhesion kinase 1 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:266 → 535
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 215
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:767 → 896
      Focal_AT; Focal adhesion targeting region

    103. NM_001387636.1 → NP_001374565.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    104. NM_001387637.1 → NP_001374566.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Related
      ENSP00000378644.3, ENST00000395218.3
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    105. NM_001387638.1 → NP_001374567.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:919 → 1048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    106. NM_001387639.1 → NP_001374568.1  focal adhesion kinase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:932 → 1061
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    107. NM_001387640.1 → NP_001374569.1  focal adhesion kinase 1 isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:456 → 725
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:939 → 1068
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    108. NM_001387641.1 → NP_001374570.1  focal adhesion kinase 1 isoform 72

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:428 → 697
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49 → 271
      B41; Band 4.1 homologues
      cd13190
      Location:267 → 377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:929 → 1058
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:48 → 143
      FERM_N_2; FERM N-terminal domain

    109. NM_001387642.1 → NP_001374571.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    110. NM_001387643.1 → NP_001374572.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94347.1
      UniProtKB/TrEMBL
      A0A059VC25, E7ESA6
      Conserved Domains (5) summary
      cd05056
      Location:459 → 728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79 → 174
      FERM_N_2; FERM N-terminal domain

    111. NM_001387644.1 → NP_001374573.1  focal adhesion kinase 1 isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:462 → 731
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:49 → 271
      B41; Band 4.1 homologues
      cd13190
      Location:267 → 377
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:966 → 1095
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:48 → 143
      FERM_N_2; FERM N-terminal domain

    112. NM_001387645.1 → NP_001374574.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    113. NM_001387646.1 → NP_001374575.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94347.1
      UniProtKB/TrEMBL
      A0A059VC25, E7ESA6
      Conserved Domains (5) summary
      cd05056
      Location:459 → 728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79 → 174
      FERM_N_2; FERM N-terminal domain

    114. NM_001387647.1 → NP_001374576.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    115. NM_001387648.1 → NP_001374577.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94347.1
      UniProtKB/TrEMBL
      A0A059VC25, E7ESA6
      Conserved Domains (5) summary
      cd05056
      Location:459 → 728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79 → 174
      FERM_N_2; FERM N-terminal domain

    116. NM_001387649.1 → NP_001374578.1  focal adhesion kinase 1 isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (3) summary
      cd05056
      Location:472 → 741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

    117. NM_001387650.1 → NP_001374579.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94347.1
      UniProtKB/TrEMBL
      A0A059VC25, E7ESA6
      Conserved Domains (5) summary
      cd05056
      Location:459 → 728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79 → 174
      FERM_N_2; FERM N-terminal domain

    118. NM_001387651.1 → NP_001374580.1  focal adhesion kinase 1 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC100860, AC105009
      Consensus CDS
      CCDS94345.1
      UniProtKB/TrEMBL
      E5RFW9, E5RI72
      Related
      ENSP00000427904.1, ENST00000520892.5
      Conserved Domains (1) summary
      pfam18038
      Location:35 → 121
      FERM_N_2; FERM N-terminal domain

    119. NM_001387652.1 → NP_001374581.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    120. NM_001387653.1 → NP_001374582.1  focal adhesion kinase 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:379 → 648
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 328
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:880 → 1009
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    121. NM_001387654.1 → NP_001374583.1  focal adhesion kinase 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      Q59GN8
      Conserved Domains (4) summary
      cd05056
      Location:302 → 571
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:9 → 145
      B41; Band 4.1 homologues
      cd13190
      Location:141 → 251
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:803 → 932
      Focal_AT; Focal adhesion targeting region

    122. NM_001387655.1 → NP_001374584.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    123. NM_001387656.1 → NP_001374585.1  focal adhesion kinase 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:898 → 1027
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    124. NM_001387657.1 → NP_001374586.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    125. NM_001387658.1 → NP_001374587.1  focal adhesion kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    126. NM_001387659.1 → NP_001374588.1  focal adhesion kinase 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:919 → 1048
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    127. NM_001387660.1 → NP_001374589.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94347.1
      UniProtKB/TrEMBL
      A0A059VC25, E7ESA6
      Related
      ENSP00000429082.1, ENST00000517887.5
      Conserved Domains (5) summary
      cd05056
      Location:459 → 728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79 → 174
      FERM_N_2; FERM N-terminal domain

    128. NM_001387661.1 → NP_001374590.1  focal adhesion kinase 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Consensus CDS
      CCDS94347.1
      UniProtKB/TrEMBL
      A0A059VC25, E7ESA6
      Conserved Domains (5) summary
      cd05056
      Location:459 → 728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:960 → 1089
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79 → 174
      FERM_N_2; FERM N-terminal domain

    129. NM_001387662.1 → NP_001374591.1  focal adhesion kinase 1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (5) summary
      cd05056
      Location:459 → 728
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:80 → 302
      B41; Band 4.1 homologues
      cd13190
      Location:298 → 408
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:963 → 1092
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:79 → 174
      FERM_N_2; FERM N-terminal domain

    130. NM_005607.5 → NP_005598.3  focal adhesion kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_005598.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AB209083, AC067931, AC100860, AL832961, BF434494, DA236314
      UniProtKB/TrEMBL
      A0A059VC25, Q658W2
      Conserved Domains (6) summary
      cd05056
      Location:437 → 706
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:58 → 280
      B41; Band 4.1 homologues
      cd13190
      Location:276 → 386
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:165 → 270
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:938 → 1067
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:444 → 698
      Pkinase_Tyr; Protein tyrosine kinase

    131. NM_153831.4 → NP_722560.1  focal adhesion kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_722560.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1 and 5 both encode the same isoform (a).
      Source sequence(s)
      AB209083, AC067931, AL832961, BF434494, DA236314, L13616
      Consensus CDS
      CCDS6381.1
      UniProtKB/Swiss-Prot
      B4E2N6, F5H4S4, J3QT16, Q05397, Q14291, Q8IYN9, Q9UD85
      UniProtKB/TrEMBL
      A0A059VC25
      Related
      ENSP00000429911.1, ENST00000522684.5
      Conserved Domains (5) summary
      cd05056
      Location:415 → 684
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 364
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:916 → 1045
      Focal_AT; Focal adhesion targeting region
      pfam18038
      Location:35 → 130
      FERM_N_2; FERM N-terminal domain

    RNA

    1. NR_148036.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    2. NR_148037.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    3. NR_148038.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    4. NR_148039.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    5. NR_170670.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC100860

    6. NR_170671.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235
      Related
      ENST00000519993.5

    7. NR_170672.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    8. NR_170673.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC067931, AC100860, AC105009, AC105235

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      140657900..141002079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422049.1 → XP_047278005.1  focal adhesion kinase 1 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3WLM4

    2. XM_047422021.1 → XP_047277977.1  focal adhesion kinase 1 isoform X4

    3. XM_047422054.1 → XP_047278010.1  focal adhesion kinase 1 isoform X38

    4. XM_047422052.1 → XP_047278008.1  focal adhesion kinase 1 isoform X37

    5. XM_047422050.1 → XP_047278006.1  focal adhesion kinase 1 isoform X36

    6. XM_047422039.1 → XP_047277995.1  focal adhesion kinase 1 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3WLM4

    7. XM_047422045.1 → XP_047278001.1  focal adhesion kinase 1 isoform X32

    8. XM_024447209.2 → XP_024302977.1  focal adhesion kinase 1 isoform X30

      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:437 → 706
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87 → 309
      B41; Band 4.1 homologues
      cd13190
      Location:305 → 379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:941 → 1070
      Focal_AT; Focal adhesion targeting region

    9. XM_047422046.1 → XP_047278002.1  focal adhesion kinase 1 isoform X33

    10. XM_024447208.2 → XP_024302976.1  focal adhesion kinase 1 isoform X28

      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:443 → 712
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87 → 309
      B41; Band 4.1 homologues
      cd13190
      Location:305 → 379
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:947 → 1076
      Focal_AT; Focal adhesion targeting region

    11. XM_047422032.1 → XP_047277988.1  focal adhesion kinase 1 isoform X15

    12. XM_047422043.1 → XP_047277999.1  focal adhesion kinase 1 isoform X29

    13. XM_024447207.2 → XP_024302975.1  focal adhesion kinase 1 isoform X27

      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:466 → 735
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87 → 309
      B41; Band 4.1 homologues
      cd13190
      Location:305 → 415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:949 → 1078
      Focal_AT; Focal adhesion targeting region

    14. XM_047422035.1 → XP_047277991.1  focal adhesion kinase 1 isoform X20

    15. XM_047422033.1 → XP_047277989.1  focal adhesion kinase 1 isoform X18

    16. XM_047422040.1 → XP_047277996.1  focal adhesion kinase 1 isoform X25

    17. XM_024447202.2 → XP_024302970.1  focal adhesion kinase 1 isoform X16

      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:473 → 742
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87 → 309
      B41; Band 4.1 homologues
      cd13190
      Location:305 → 415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:974 → 1103
      Focal_AT; Focal adhesion targeting region

    18. XM_047422029.1 → XP_047277985.1  focal adhesion kinase 1 isoform X12

    19. XM_047422041.1 → XP_047277997.1  focal adhesion kinase 1 isoform X26

    20. XM_024447203.2 → XP_024302971.1  focal adhesion kinase 1 isoform X17

      UniProtKB/TrEMBL
      A0A059VC25
      Conserved Domains (4) summary
      cd05056
      Location:472 → 741
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:87 → 309
      B41; Band 4.1 homologues
      cd13190
      Location:305 → 415
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      pfam03623
      Location:973 → 1102
      Focal_AT; Focal adhesion targeting region

    21. XM_047422030.1 → XP_047277986.1  focal adhesion kinase 1 isoform X13

    22. XM_047422038.1 → XP_047277994.1  focal adhesion kinase 1 isoform X23

    23. XM_047422026.1 → XP_047277982.1  focal adhesion kinase 1 isoform X9

    24. XM_047422025.1 → XP_047277981.1  focal adhesion kinase 1 isoform X8

    25. XM_047422027.1 → XP_047277983.1  focal adhesion kinase 1 isoform X10

    26. XM_047422022.1 → XP_047277978.1  focal adhesion kinase 1 isoform X5

    27. XM_047422018.1 → XP_047277974.1  focal adhesion kinase 1 isoform X3

    28. XM_047422024.1 → XP_047277980.1  focal adhesion kinase 1 isoform X7

    29. XM_047422023.1 → XP_047277979.1  focal adhesion kinase 1 isoform X6

    30. XM_047422017.1 → XP_047277973.1  focal adhesion kinase 1 isoform X2

    31. XM_047422016.1 → XP_047277972.1  focal adhesion kinase 1 isoform X1

    32. XM_047422047.1 → XP_047278003.1  focal adhesion kinase 1 isoform X34

    33. XM_047422037.1 → XP_047277993.1  focal adhesion kinase 1 isoform X22

    34. XM_047422036.1 → XP_047277992.1  focal adhesion kinase 1 isoform X21

    35. XM_047422034.1 → XP_047277990.1  focal adhesion kinase 1 isoform X19

    36. XM_047422031.1 → XP_047277987.1  focal adhesion kinase 1 isoform X14

    37. XM_047422028.1 → XP_047277984.1  focal adhesion kinase 1 isoform X11

    38. XM_047422019.1 → XP_047277975.1  focal adhesion kinase 1 isoform X4

    39. XM_047422053.1 → XP_047278009.1  focal adhesion kinase 1 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3WLM4

    40. XM_047422044.1 → XP_047278000.1  focal adhesion kinase 1 isoform X31

    41. XM_047422020.1 → XP_047277976.1  focal adhesion kinase 1 isoform X4

    42. XM_047422048.1 → XP_047278004.1  focal adhesion kinase 1 isoform X35

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      141777902..142122150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360920.1 → XP_054216895.1  focal adhesion kinase 1 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3WLM4

    2. XM_054360924.1 → XP_054216899.1  focal adhesion kinase 1 isoform X38

    3. XM_054360922.1 → XP_054216897.1  focal adhesion kinase 1 isoform X37

    4. XM_054360921.1 → XP_054216896.1  focal adhesion kinase 1 isoform X36

    5. XM_054360908.1 → XP_054216883.1  focal adhesion kinase 1 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3WLM4

    6. XM_054360916.1 → XP_054216891.1  focal adhesion kinase 1 isoform X32

    7. XM_054360914.1 → XP_054216889.1  focal adhesion kinase 1 isoform X30

    8. XM_054360917.1 → XP_054216892.1  focal adhesion kinase 1 isoform X33

    9. XM_054360912.1 → XP_054216887.1  focal adhesion kinase 1 isoform X28

    10. XM_054360898.1 → XP_054216873.1  focal adhesion kinase 1 isoform X15

    11. XM_054360913.1 → XP_054216888.1  focal adhesion kinase 1 isoform X29

    12. XM_054360911.1 → XP_054216886.1  focal adhesion kinase 1 isoform X27

    13. XM_054360903.1 → XP_054216878.1  focal adhesion kinase 1 isoform X20

    14. XM_054360901.1 → XP_054216876.1  focal adhesion kinase 1 isoform X18

    15. XM_054360909.1 → XP_054216884.1  focal adhesion kinase 1 isoform X25

    16. XM_054360899.1 → XP_054216874.1  focal adhesion kinase 1 isoform X16

    17. XM_054360895.1 → XP_054216870.1  focal adhesion kinase 1 isoform X12

    18. XM_054360910.1 → XP_054216885.1  focal adhesion kinase 1 isoform X26

    19. XM_054360900.1 → XP_054216875.1  focal adhesion kinase 1 isoform X17

    20. XM_054360896.1 → XP_054216871.1  focal adhesion kinase 1 isoform X13

    21. XM_054360906.1 → XP_054216881.1  focal adhesion kinase 1 isoform X23

    22. XM_054360892.1 → XP_054216867.1  focal adhesion kinase 1 isoform X9

    23. XM_054360891.1 → XP_054216866.1  focal adhesion kinase 1 isoform X8

    24. XM_054360893.1 → XP_054216868.1  focal adhesion kinase 1 isoform X10

    25. XM_054360888.1 → XP_054216863.1  focal adhesion kinase 1 isoform X5

    26. XM_054360885.1 → XP_054216860.1  focal adhesion kinase 1 isoform X3

    27. XM_054360890.1 → XP_054216865.1  focal adhesion kinase 1 isoform X7

    28. XM_054360889.1 → XP_054216864.1  focal adhesion kinase 1 isoform X6

    29. XM_054360884.1 → XP_054216859.1  focal adhesion kinase 1 isoform X2

    30. XM_054360883.1 → XP_054216858.1  focal adhesion kinase 1 isoform X1

    31. XM_054360918.1 → XP_054216893.1  focal adhesion kinase 1 isoform X34

    32. XM_054360905.1 → XP_054216880.1  focal adhesion kinase 1 isoform X22

    33. XM_054360904.1 → XP_054216879.1  focal adhesion kinase 1 isoform X21

    34. XM_054360902.1 → XP_054216877.1  focal adhesion kinase 1 isoform X19

    35. XM_054360897.1 → XP_054216872.1  focal adhesion kinase 1 isoform X14

    36. XM_054360894.1 → XP_054216869.1  focal adhesion kinase 1 isoform X11

    37. XM_054360886.1 → XP_054216861.1  focal adhesion kinase 1 isoform X4

    38. XM_054360923.1 → XP_054216898.1  focal adhesion kinase 1 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3WLM4

    39. XM_054360915.1 → XP_054216890.1  focal adhesion kinase 1 isoform X31

    40. XM_054360887.1 → XP_054216862.1  focal adhesion kinase 1 isoform X4

    41. XM_054360907.1 → XP_054216882.1  focal adhesion kinase 1 isoform X24

      UniProtKB/TrEMBL
      A0A8Q3WLM4

    42. XM_054360919.1 → XP_054216894.1  focal adhesion kinase 1 isoform X35

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05397.2 GenPept UniProtKB/Swiss-Prot:Q05397

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