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Conserved domains on  [gi|1208914968|ref|NP_001339678|]
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focal adhesion kinase 1 isoform 42 [Homo sapiens]

Protein Classification

focal adhesion kinase( domain architecture ID 10508098)

focal adhesion kinase (FAK) is a cytoplasmic (non-receptor) protein-tyrosine kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates, and is involved in integrin-mediated signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Focal_AT pfam03623
Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in ...
 229-358 1.71e-78

Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.


:

Pssm-ID: 460992  Cd Length: 130  Bit Score: 236.78  E-value: 1.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208914968 229 NLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLG 308
Cdd:pfam03623   1 DLDRTNDKVYECVTRVVKAVMQLSQEVQTAKPDEYVDLVKNVGLELRNLLTSVDELLPILPASSHREIEMAQKLLNKDLA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1208914968 309 ELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKM 358
Cdd:pfam03623  81 ELINKMKLAQQYSITTLDEEYRKQMLTAAHTLAMDAKNLLDVVDSARLRA 130
 
Name Accession Description Interval E-value
Focal_AT pfam03623
Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in ...
 229-358 1.71e-78

Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.


Pssm-ID: 460992  Cd Length: 130  Bit Score: 236.78  E-value: 1.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208914968 229 NLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLG 308
Cdd:pfam03623   1 DLDRTNDKVYECVTRVVKAVMQLSQEVQTAKPDEYVDLVKNVGLELRNLLTSVDELLPILPASSHREIEMAQKLLNKDLA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1208914968 309 ELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKM 358
Cdd:pfam03623  81 ELINKMKLAQQYSITTLDEEYRKQMLTAAHTLAMDAKNLLDVVDSARLRA 130
 
Name Accession Description Interval E-value
Focal_AT pfam03623
Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in ...
 229-358 1.71e-78

Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.


Pssm-ID: 460992  Cd Length: 130  Bit Score: 236.78  E-value: 1.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1208914968 229 NLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLG 308
Cdd:pfam03623   1 DLDRTNDKVYECVTRVVKAVMQLSQEVQTAKPDEYVDLVKNVGLELRNLLTSVDELLPILPASSHREIEMAQKLLNKDLA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1208914968 309 ELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKM 358
Cdd:pfam03623  81 ELINKMKLAQQYSITTLDEEYRKQMLTAAHTLAMDAKNLLDVVDSARLRA 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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