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    TNNT3 troponin T3, fast skeletal type [ Homo sapiens (human) ]

    Gene ID: 7140, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TNNT3provided by HGNC
    Official Full Name
    troponin T3, fast skeletal typeprovided by HGNC
    Primary source
    HGNC:HGNC:11950
    See related
    Ensembl:ENSG00000130595 MIM:600692; AllianceGenome:HGNC:11950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNTF; DA2B2; beta-TnTF
    Summary
    The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in esophagus (RPKM 25.1), prostate (RPKM 20.2) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNNT3 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1919552..1938702)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1983592..2002746)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1940933..1959932)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lymphocyte specific protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4294 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1908437-1908603 Neighboring gene microRNA 7847 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:1918050-1919249 Neighboring gene proline rich 33 Neighboring gene long intergenic non-protein coding RNA 1150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1927717-1928218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1928219-1928718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4295 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1956346-1956534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1956988-1957585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1970491-1971228 Neighboring gene small nucleolar RNA, C/D box 131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1979269-1980047 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene VISTA enhancer hs1488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2003101-2003870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2004639-2005408 Neighboring gene H19/IGF2 enhancer region Neighboring gene MRPL23 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical analysis of a variant of Freeman-Sheldon syndrome (DA2B). Krakowiak PA, et al. Am J Med Genet, 1998 Feb 26. PMID 9508073
    2. A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus. Zhao N, et al. Eur J Med Genet, 2011 May-Jun. PMID 21402185
    3. The distal arthrogryposis-linked p.R63C variant promotes the stability and nuclear accumulation of TNNT3. Lu J, et al. J Clin Lab Anal, 2021 Dec. PMID 34766372, Free PMC Article
    4. Structure and sequence of the human fast skeletal troponin T (TNNT3) gene: insight into the evolution of the gene and the origin of the developmentally regulated isoforms. Stefancsik R, et al. Comp Funct Genomics, 2003. PMID 18629027, Free PMC Article
    5. Role of the fetal and alpha/beta exons in the function of fast skeletal troponin T isoforms: correlation with altered Ca2+ regulation associated with development. Chaudhuri T, et al. J Mol Biol, 2005 Sep 9. PMID 16081096

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The distal arthrogryposis-linked p.R63C variant promotes the stability and nuclear accumulation of TNNT3.
      Title: The distal arthrogryposis-linked p.R63C variant promotes the stability and nuclear accumulation of TNNT3.
    2. The TnT3 appears to contribute to age-related sarcopenia and possibly other age-related deficiencies such as muscle insulin resistance and beta cell dysfunction by interacting with TnT3-binding sequences in the promoter area of p53-related genes, among others, and consequently modulating the transcriptional regulation of these target genes.
      Title: Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs.
    3. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.
      Title: TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.
    4. The presence of the p.(Arg63His) missense mutation at position 63 of TNNT3 was confirmed through direct cycle sequencing of genomic DNA in six affected South African family members for whom DNA had been archived.
      Title: Digitotalar dysmorphism: Molecular elucidation.
    5. Data show that a missense mutation at nucleotide position 187 in exon 9 of the TNNT3 gene was identified in all affected individuals in the family.
      Title: A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    7. TNNT3 and LDB3 showed abnormal splicing and appeared more pronounced in myotonic dystrophies type 2 relative to myotonic dystrophies type 1.
      Title: Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2.
    8. Myotonic dystrophy type 2 muscles exhibited a higher degree of alternative splicing dysregulation for fast TnT transcripts when compared to myotonic dystrophy type 1 muscles.
      Title: Comparative transcriptional and biochemical studies in muscle of myotonic dystrophies (DM1 and DM2).
    9. Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot.
      Title: Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Arthrogryposis, distal, type 2B2
    MedGen: C5193097 OMIM: 618435 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
    EBI GWAS Catalog
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp779M2348

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to tropomyosin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tropomyosin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables troponin C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables troponin C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables troponin I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables troponin I binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of calcium-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of striated muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of troponin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    troponin T, fast skeletal muscle
    Names
    troponin T type 3 (skeletal, fast)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013085.2 RefSeqGene

      Range
      5135..24134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_850

    mRNA and Protein(s)

    1. NM_001042780.3 → NP_001036245.1  troponin T, fast skeletal muscle isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal coding exons and contains one different coding exon compared to transcript variant 1. However, it maintains the reading frame, and encodes a shorter isoform (3) with a different internal segment compared to isoform 1.
      Source sequence(s)
      BC050446, BC117327, BX640689, DA897990
      Consensus CDS
      CCDS41595.1
      UniProtKB/TrEMBL
      C9JZN9, F8WA37
      Related
      ENSP00000370991.3, ENST00000381579.7
      Conserved Domains (1) summary
      pfam00992
      Location:54 → 189
      Troponin; Troponin

    2. NM_001042781.3 → NP_001036246.1  troponin T, fast skeletal muscle isoform 2

      See identical proteins and their annotated locations for NP_001036246.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains two different internal coding exons and lacks another coding exon compared to transcript variant 1. However, it maintains the reading frame, and encodes a slightly shorter isoform (2) with a different internal segment compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).
      Source sequence(s)
      BX640689, CR541927, DA897990
      Consensus CDS
      CCDS41594.1
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000371001.3, ENST00000381589.7
      Conserved Domains (1) summary
      pfam00992
      Location:60 → 195
      Troponin; Troponin

    3. NM_001042782.3 → NP_001036247.1  troponin T, fast skeletal muscle isoform 4

      See identical proteins and their annotated locations for NP_001036247.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal coding exon compared to transcript variant 1, resulting in a shorter isoform (4) missing an 8 aa segment compared to isoform 1. Variants 4, 5, and 9 all encode the same isoform (4).
      Source sequence(s)
      BC117327, BX640689, DA897990
      Consensus CDS
      CCDS41596.1
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000370969.2, ENST00000381557.6
      Conserved Domains (1) summary
      pfam00992
      Location:54 → 189
      Troponin; Troponin

    4. NM_001297646.2 → NP_001284575.1  troponin T, fast skeletal muscle isoform 4

      See identical proteins and their annotated locations for NP_001284575.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an internal coding exon compared to transcript variant 1, resulting in a shorter isoform (4) missing an 8 aa segment compared to isoform 1. Variants 4, 5, and 9 all encode the same isoform (4).
      Source sequence(s)
      AC051649, AK056968, DA897990, F26088
      Consensus CDS
      CCDS41596.1
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000370970.1, ENST00000381558.6
      Conserved Domains (1) summary
      pfam00992
      Location:54 → 189
      Troponin; Troponin

    5. NM_001363561.2 → NP_001350490.1  troponin T, fast skeletal muscle isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 12, encodes isoform 5.
      Source sequence(s)
      AC051649
      Consensus CDS
      CCDS86164.1
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000370975.4, ENST00000381563.8
      Conserved Domains (1) summary
      pfam00992
      Location:65 → 200
      Troponin; Troponin

    6. NM_001367842.1 → NP_001354771.1  troponin T, fast skeletal muscle isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC051649, BC171727
      Consensus CDS
      CCDS41594.1
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000492914.1, ENST00000641119.1

    7. NM_001367843.1 → NP_001354772.1  troponin T, fast skeletal muscle isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC051649
      UniProtKB/TrEMBL
      A0A9L9PY19, F8WA37
      Related
      ENSP00000516410.1, ENST00000706488.1

    8. NM_001367844.1 → NP_001354773.1  troponin T, fast skeletal muscle isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 4 and 5, encodes isoform 4.
      Source sequence(s)
      AC051649, BC117327
      Consensus CDS
      CCDS41596.1
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000493331.1, ENST00000641787.1

    9. NM_001367845.1 → NP_001354774.1  troponin T, fast skeletal muscle isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC051649
      UniProtKB/TrEMBL
      F8WA37

    10. NM_001367846.1 → NP_001354775.1  troponin T, fast skeletal muscle isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) encodes the longest isoform (8).
      Source sequence(s)
      AC051649
      Consensus CDS
      CCDS91403.1
      UniProtKB/Swiss-Prot
      A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
      UniProtKB/TrEMBL
      F8WA37

    11. NM_001367847.1 → NP_001354776.1  troponin T, fast skeletal muscle isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 6, encodes isoform 5.
      Source sequence(s)
      AC051649
      Consensus CDS
      CCDS86164.1
      UniProtKB/TrEMBL
      F8WA37

    12. NM_001367848.1 → NP_001354777.1  troponin T, fast skeletal muscle isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC051649
      UniProtKB/TrEMBL
      F8WA37

    13. NM_001367849.1 → NP_001354778.1  troponin T, fast skeletal muscle isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC051649
      UniProtKB/TrEMBL
      F8WA37

    14. NM_001367850.1 → NP_001354779.1  troponin T, fast skeletal muscle isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC051649
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000415614.1, ENST00000453458.5

    15. NM_001367851.1 → NP_001354780.1  troponin T, fast skeletal muscle isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform 12.
      Source sequence(s)
      AC051649
      Consensus CDS
      CCDS91406.1
      UniProtKB/TrEMBL
      A0A286YFB1
      Conserved Domains (1) summary
      pfam00992
      Location:1 → 129
      Troponin

    16. NM_001367852.1 → NP_001354781.1  troponin T, fast skeletal muscle isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform 12.
      Source sequence(s)
      AC051649, BC171728
      Consensus CDS
      CCDS91406.1
      UniProtKB/TrEMBL
      A0A286YFB1
      Related
      ENSP00000493372.1, ENST00000641225.1
      Conserved Domains (1) summary
      pfam00992
      Location:1 → 129
      Troponin

    17. NM_006757.4 → NP_006748.1  troponin T, fast skeletal muscle isoform 1

      See identical proteins and their annotated locations for NP_006748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC117327, BX640689, DA897990, M21984
      Consensus CDS
      CCDS7727.1
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000278317.6, ENST00000278317.11
      Conserved Domains (1) summary
      pfam00992
      Location:62 → 197
      Troponin; Troponin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1919552..1938702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018206.2 → XP_016873695.1  troponin T, fast skeletal muscle isoform X3

      UniProtKB/Swiss-Prot
      A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000380468.1, ENST00000397301.5
      Conserved Domains (1) summary
      pfam00992
      Location:73 → 208
      Troponin; Troponin

    2. XM_024448669.2 → XP_024304437.1  troponin T, fast skeletal muscle isoform X7

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:60 → 195
      Troponin; Troponin

    3. XM_017018207.2 → XP_016873696.1  troponin T, fast skeletal muscle isoform X4

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:69 → 204
      Troponin; Troponin

    4. XM_017018209.2 → XP_016873698.1  troponin T, fast skeletal muscle isoform X6

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:61 → 196
      Troponin; Troponin

    5. XM_017018211.2 → XP_016873700.1  troponin T, fast skeletal muscle isoform X9

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:56 → 191
      Troponin; Troponin

    6. XM_006718294.4 → XP_006718357.1  troponin T, fast skeletal muscle isoform X1

      UniProtKB/TrEMBL
      C9JZN9
      Conserved Domains (1) summary
      pfam00992
      Location:65 → 200
      Troponin; Troponin

    7. XM_017018205.2 → XP_016873694.1  troponin T, fast skeletal muscle isoform X2

      UniProtKB/TrEMBL
      A0A9L9PY19, F8WA37

    8. XM_006718299.3 → XP_006718362.1  troponin T, fast skeletal muscle isoform X20

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:53 → 189
      Troponin

    9. XM_006718300.4 → XP_006718363.1  troponin T, fast skeletal muscle isoform X21

      See identical proteins and their annotated locations for XP_006718363.1

      UniProtKB/TrEMBL
      F8WA37
      Related
      ENSP00000344870.4, ENST00000344578.8
      Conserved Domains (1) summary
      pfam00992
      Location:49 → 184
      Troponin; Troponin

    10. XM_017018216.2 → XP_016873705.1  troponin T, fast skeletal muscle isoform X17

      UniProtKB/TrEMBL
      F8WA37

    11. XM_017018217.2 → XP_016873706.1  troponin T, fast skeletal muscle isoform X18

      UniProtKB/TrEMBL
      F8WA37

    12. XM_017018218.2 → XP_016873707.1  troponin T, fast skeletal muscle isoform X19

      UniProtKB/TrEMBL
      F8WA37

    13. XM_017018219.2 → XP_016873708.1  troponin T, fast skeletal muscle isoform X22

      UniProtKB/TrEMBL
      C9JZN9, H9KVA2
      Related
      ENSP00000380471.2, ENST00000397304.6

    14. XM_011520343.3 → XP_011518645.1  troponin T, fast skeletal muscle isoform X3

      See identical proteins and their annotated locations for XP_011518645.1

      UniProtKB/Swiss-Prot
      A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:73 → 208
      Troponin; Troponin

    15. XM_017018208.2 → XP_016873697.1  troponin T, fast skeletal muscle isoform X5

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:66 → 201
      Troponin; Troponin

    16. XM_017018210.2 → XP_016873699.1  troponin T, fast skeletal muscle isoform X8

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:58 → 193
      Troponin; Troponin

    17. XM_024448671.2 → XP_024304439.1  troponin T, fast skeletal muscle isoform X12

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:53 → 189
      Troponin

    18. XM_017018214.2 → XP_016873703.1  troponin T, fast skeletal muscle isoform X14

      UniProtKB/TrEMBL
      C9JZN9, F8WA37
      Related
      ENSP00000413203.1, ENST00000446240.1
      Conserved Domains (1) summary
      pfam00992
      Location:49 → 184
      Troponin; Troponin

    19. XM_024448670.2 → XP_024304438.1  troponin T, fast skeletal muscle isoform X11

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:54 → 189
      Troponin

    20. XM_017018212.2 → XP_016873701.1  troponin T, fast skeletal muscle isoform X10

      UniProtKB/TrEMBL
      F8WA37

    21. XM_017018213.2 → XP_016873702.1  troponin T, fast skeletal muscle isoform X13

      UniProtKB/TrEMBL
      F8WA37

    22. XM_017018215.2 → XP_016873704.1  troponin T, fast skeletal muscle isoform X15

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:47 → 182
      Troponin; Troponin

    23. XM_024448672.2 → XP_024304440.1  troponin T, fast skeletal muscle isoform X16

      UniProtKB/TrEMBL
      F8WA37
      Conserved Domains (1) summary
      pfam00992
      Location:47 → 182
      Troponin; Troponin

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160004.1 Reference GRCh38.p14 PATCHES

      Range
      88376..107530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332449.1 → XP_054188424.1  troponin T, fast skeletal muscle isoform X3

      UniProtKB/Swiss-Prot
      A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

    2. XM_054332453.1 → XP_054188428.1  troponin T, fast skeletal muscle isoform X7

    3. XM_054332450.1 → XP_054188425.1  troponin T, fast skeletal muscle isoform X4

    4. XM_054332452.1 → XP_054188427.1  troponin T, fast skeletal muscle isoform X6

    5. XM_054332455.1 → XP_054188430.1  troponin T, fast skeletal muscle isoform X9

    6. XM_054332447.1 → XP_054188422.1  troponin T, fast skeletal muscle isoform X1

    7. XM_054332448.1 → XP_054188423.1  troponin T, fast skeletal muscle isoform X2

      UniProtKB/TrEMBL
      A0A9L9PY19

    8. XM_054332467.1 → XP_054188442.1  troponin T, fast skeletal muscle isoform X20

    9. XM_054332468.1 → XP_054188443.1  troponin T, fast skeletal muscle isoform X21

    10. XM_054332464.1 → XP_054188439.1  troponin T, fast skeletal muscle isoform X17

    11. XM_054332465.1 → XP_054188440.1  troponin T, fast skeletal muscle isoform X18

    12. XM_054332466.1 → XP_054188441.1  troponin T, fast skeletal muscle isoform X19

    13. XM_054332469.1 → XP_054188444.1  troponin T, fast skeletal muscle isoform X22

      UniProtKB/TrEMBL
      H9KVA2

    14. XM_054332463.1 → XP_054188438.1  troponin T, fast skeletal muscle isoform X3

      UniProtKB/Swiss-Prot
      A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

    15. XM_054332451.1 → XP_054188426.1  troponin T, fast skeletal muscle isoform X5

    16. XM_054332454.1 → XP_054188429.1  troponin T, fast skeletal muscle isoform X8

    17. XM_054332458.1 → XP_054188433.1  troponin T, fast skeletal muscle isoform X12

    18. XM_054332460.1 → XP_054188435.1  troponin T, fast skeletal muscle isoform X14

    19. XM_054332457.1 → XP_054188432.1  troponin T, fast skeletal muscle isoform X11

    20. XM_054332456.1 → XP_054188431.1  troponin T, fast skeletal muscle isoform X10

    21. XM_054332459.1 → XP_054188434.1  troponin T, fast skeletal muscle isoform X13

    22. XM_054332461.1 → XP_054188436.1  troponin T, fast skeletal muscle isoform X15

    23. XM_054332462.1 → XP_054188437.1  troponin T, fast skeletal muscle isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1983592..2002746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369780.1 → XP_054225755.1  troponin T, fast skeletal muscle isoform X3

      UniProtKB/Swiss-Prot
      A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

    2. XM_054369784.1 → XP_054225759.1  troponin T, fast skeletal muscle isoform X7

    3. XM_054369781.1 → XP_054225756.1  troponin T, fast skeletal muscle isoform X4

    4. XM_054369783.1 → XP_054225758.1  troponin T, fast skeletal muscle isoform X6

    5. XM_054369786.1 → XP_054225761.1  troponin T, fast skeletal muscle isoform X9

    6. XM_054369778.1 → XP_054225753.1  troponin T, fast skeletal muscle isoform X1

    7. XM_054369779.1 → XP_054225754.1  troponin T, fast skeletal muscle isoform X2

      UniProtKB/TrEMBL
      A0A9L9PY19

    8. XM_054369798.1 → XP_054225773.1  troponin T, fast skeletal muscle isoform X20

    9. XM_054369799.1 → XP_054225774.1  troponin T, fast skeletal muscle isoform X21

    10. XM_054369795.1 → XP_054225770.1  troponin T, fast skeletal muscle isoform X17

    11. XM_054369796.1 → XP_054225771.1  troponin T, fast skeletal muscle isoform X18

    12. XM_054369797.1 → XP_054225772.1  troponin T, fast skeletal muscle isoform X19

    13. XM_054369800.1 → XP_054225775.1  troponin T, fast skeletal muscle isoform X22

      UniProtKB/TrEMBL
      H9KVA2

    14. XM_054369794.1 → XP_054225769.1  troponin T, fast skeletal muscle isoform X3

      UniProtKB/Swiss-Prot
      A8MQ76, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, P45378, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6

    15. XM_054369782.1 → XP_054225757.1  troponin T, fast skeletal muscle isoform X5

    16. XM_054369785.1 → XP_054225760.1  troponin T, fast skeletal muscle isoform X8

    17. XM_054369789.1 → XP_054225764.1  troponin T, fast skeletal muscle isoform X12

    18. XM_054369791.1 → XP_054225766.1  troponin T, fast skeletal muscle isoform X14

    19. XM_054369788.1 → XP_054225763.1  troponin T, fast skeletal muscle isoform X11

    20. XM_054369787.1 → XP_054225762.1  troponin T, fast skeletal muscle isoform X10

    21. XM_054369790.1 → XP_054225765.1  troponin T, fast skeletal muscle isoform X13

    22. XM_054369792.1 → XP_054225767.1  troponin T, fast skeletal muscle isoform X15

    23. XM_054369793.1 → XP_054225768.1  troponin T, fast skeletal muscle isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45378.3 GenPept UniProtKB/Swiss-Prot:P45378

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