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Conserved domains on  [gi|1034575146|ref|XP_016873697|]
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troponin T, fast skeletal muscle isoform X5 [Homo sapiens]

Protein Classification

troponin( domain architecture ID 12013160)

troponin such as troponin I (TnI, inhibitory) and T (TnT, tropomyosin binding) subunits, which together with troponin C (TnC, Ca2+ binding) subunit, form the troponin complex that regulates Ca2+ induced muscle contraction

CATH:  1.20.5.350
Gene Ontology:  GO:0005861|GO:0003009
PubMed:  18154728

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 66-202 3.38e-18

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


:

Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 78.37  E-value: 3.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146  66 KRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAER--AEQQRIRAEKERERQNRLAEEKARREEEDAKRRAED 143
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGlsAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034575146 144 DLKKKKALSSMGAnyssylAKADQKRGKKQTAREMKKKILAERRKpLNIDHLGEDKLRD 202
Cdd:pfam00992  81 NDLKKKVNDLRGK------FKKPLLKKVRKTADAMLKALLGSKHK-VSMDFRANLKQVK 132
 
Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 66-202 3.38e-18

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 78.37  E-value: 3.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146  66 KRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAER--AEQQRIRAEKERERQNRLAEEKARREEEDAKRRAED 143
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGlsAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034575146 144 DLKKKKALSSMGAnyssylAKADQKRGKKQTAREMKKKILAERRKpLNIDHLGEDKLRD 202
Cdd:pfam00992  81 NDLKKKVNDLRGK------FKKPLLKKVRKTADAMLKALLGSKHK-VSMDFRANLKQVK 132
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 56-241 1.23e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146   56 EKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEK--------RRAERAEQQRIRAEKERERQNRLAE 127
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQlkeelkalREALDELRAELTLLNEEAANLRERL 826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146  128 EKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKEL 207
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1034575146  208 WETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQ 241
Cdd:TIGR02168  907 ESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
 55-141 9.07e-03

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 37.41  E-value: 9.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146   55 GEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVAlKERIEKRRAERAEQQRIRAEK-----------ERERQN 123
Cdd:PTZ00266   427 GGRVDKDHAERARIEKENAHRKALEMKILEKKRIERLEREE-RERLERERMERIERERLERERlererlerdrlERDRLD 505

                           90
                   ....*....|....*...
gi 1034575146  124 RLAEEKARREEEDAKRRA 141
Cdd:PTZ00266   506 RLERERVDRLERDRLEKA 523
 
Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 66-202 3.38e-18

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 78.37  E-value: 3.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146  66 KRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAER--AEQQRIRAEKERERQNRLAEEKARREEEDAKRRAED 143
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGlsAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034575146 144 DLKKKKALSSMGAnyssylAKADQKRGKKQTAREMKKKILAERRKpLNIDHLGEDKLRD 202
Cdd:pfam00992  81 NDLKKKVNDLRGK------FKKPLLKKVRKTADAMLKALLGSKHK-VSMDFRANLKQVK 132
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 56-241 1.23e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146   56 EKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEK--------RRAERAEQQRIRAEKERERQNRLAE 127
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQlkeelkalREALDELRAELTLLNEEAANLRERL 826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146  128 EKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKEL 207
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1034575146  208 WETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQ 241
Cdd:TIGR02168  907 ESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
 55-141 9.07e-03

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 37.41  E-value: 9.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034575146   55 GEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVAlKERIEKRRAERAEQQRIRAEK-----------ERERQN 123
Cdd:PTZ00266   427 GGRVDKDHAERARIEKENAHRKALEMKILEKKRIERLEREE-RERLERERMERIERERLERERlererlerdrlERDRLD 505

                           90
                   ....*....|....*...
gi 1034575146  124 RLAEEKARREEEDAKRRA 141
Cdd:PTZ00266   506 RLERERVDRLERDRLEKA 523
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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