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    Serpina7 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 331535, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Serpina7provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7provided by MGI
    Primary source
    MGI:MGI:3041197
    See related
    Ensembl:ENSMUSG00000031271 AllianceGenome:MGI:3041197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tbg; C730040N12Rik
    Summary
    Predicted to enable hormone binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of endopeptidase activity; response to vitamin A; and thyroid hormone transport. Predicted to be active in extracellular space. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 13.9), liver E14.5 (RPKM 1.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serpina7 in Genome Data Viewer
    Location:
    X F1; X 61.23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (137979998..137985985, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139079249..139085236, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47989 Neighboring gene RIKEN cDNA 4930513O06 gene Neighboring gene Nik related kinase Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern. Yan Z, et al. Gene, 2012 Sep 15. PMID 22820390
    2. Mice without macroH2A histone variants. Pehrson JR, et al. Mol Cell Biol, 2014 Dec. PMID 25312643, Free PMC Article
    3. Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice. Shigesawa I, et al. J Diabetes Investig, 2024 Sep 21. PMID 39305123
    4. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the TBG promoter has a role in sustaining transgene expression in liver-specific pattern
      Title: Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to vitamin A ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thyroxine-binding globulin
    Names
    T4-binding globulin
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
    serpin A7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382371.1 → NP_001369300.1  thyroxine-binding globulin isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732419
      UniProtKB/Swiss-Prot
      A2RSG7, P61939
      Conserved Domains (1) summary
      cd19555
      Location:40 → 418
      serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin

    2. NM_001382372.1 → NP_001369301.1  thyroxine-binding globulin isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732419
      UniProtKB/Swiss-Prot
      A2RSG7, P61939
      Conserved Domains (1) summary
      cd19555
      Location:40 → 418
      serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin

    3. NM_177920.5 → NP_808588.3  thyroxine-binding globulin isoform 1 precursor

      See identical proteins and their annotated locations for NP_808588.3

      Status: VALIDATED

      Source sequence(s)
      AK050361, AK149459, BP767390, BY099279
      Consensus CDS
      CCDS53200.1
      UniProtKB/TrEMBL
      Q3UEL9
      Related
      ENSMUSP00000033626.9, ENSMUST00000033626.15
      Conserved Domains (1) summary
      cd02056
      Location:57 → 419
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      137979998..137985985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528579.3 → XP_006528642.1  thyroxine-binding globulin isoform X1

      UniProtKB/TrEMBL
      Q8BII9
      Related
      ENSMUSP00000056166.3, ENSMUST00000060824.4
      Conserved Domains (1) summary
      cl38926
      Location:3 → 249
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61939.1 GenPept UniProtKB/Swiss-Prot:P61939

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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