U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dgat2 diacylglycerol O-acyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 67800, updated on 2-Nov-2024

    Summary

    Official Symbol
    Dgat2provided by MGI
    Official Full Name
    diacylglycerol O-acyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1915050
    See related
    Ensembl:ENSMUSG00000030747 AllianceGenome:MGI:1915050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARAT; DGAT-2; 0610010B06Rik
    Summary
    Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and protein homodimerization activity. Involved in several processes, including acylglycerol biosynthetic process; cellular response to oleic acid; and cholesterol homeostasis. Located in endoplasmic reticulum membrane and perinuclear region of cytoplasm. Colocalizes with lipid droplet and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 1253.2), mammary gland adult (RPKM 752.2) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dgat2 in Genome Data Viewer
    Location:
    7 E1; 7 54.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98802870..98831920, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99153663..99182713, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene UV radiation resistance associated gene Neighboring gene predicted gene, 23479 Neighboring gene STARR-seq mESC enhancer starr_19643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106235549-106235826 Neighboring gene predicted gene, 33882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106289887-106290074 Neighboring gene STARR-positive B cell enhancer ABC_E10454 Neighboring gene STARR-positive B cell enhancer ABC_E3734 Neighboring gene STARR-positive B cell enhancer ABC_E9023 Neighboring gene monoacylglycerol O-acyltransferase 2 Neighboring gene WW domain containing adaptor with coiled-coil pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-acylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diacylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables diacylglycerol O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinol O-fatty-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to oleic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in diacylglycerol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diacylglycerol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat pad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid storage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty-acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty-acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoacylglycerol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoacylglycerol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of plasma lipoprotein particle levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    diacylglycerol O-acyltransferase 2
    Names
    acyl-CoA retinol O-fatty-acyltransferase
    diacylglycerol acyltransferase 2
    diglyceride acyltransferase 2
    retinol O-fatty-acyltransferase
    NP_080660.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026384.3NP_080660.1  diacylglycerol O-acyltransferase 2

      See identical proteins and their annotated locations for NP_080660.1

      Status: PROVISIONAL

      Source sequence(s)
      AC115850
      Consensus CDS
      CCDS21477.1
      UniProtKB/Swiss-Prot
      Q9DCV3
      Related
      ENSMUSP00000033001.5, ENSMUST00000033001.6
      Conserved Domains (1) summary
      pfam03982
      Location:92388
      DAGAT; Diacylglycerol acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      98802870..98831920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)