NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|16975490|ref|NP_080660|]
View 

diacylglycerol O-acyltransferase 2 [Mus musculus]

Protein Classification

2-acylglycerol O-acyltransferase family protein( domain architecture ID 11146611)

2-acylglycerol O-acyltransferase family protein such as 2-acylglycerol O-acyltransferase, which catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
DAGAT pfam03982
Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is ...
92-388 0e+00

Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is catalyzed by the enzyme diacylglycerol acyltransferase (DAGAT).


:

Pssm-ID: 112781 [Multi-domain]  Cd Length: 297  Bit Score: 524.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490    92 MYTFCTDCWLIAVLYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAF 171
Cdd:pfam03982   1 FVLFFTPQWSLLVLYALWLFYDWNSPKRGGYRSNWARNWRIWKWFANYFPVKLHKTAELPPNRNYLFGYHPHGILSVGAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   172 CNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGK 251
Cdd:pfam03982  81 SNFSTNATGFMDKFPGIRPNICTLAGQFYTPFRREILLSLGLIEVSRESIEYVLDKCGKGRAVVLVVGGAAEALEAHPGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   252 NAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYS 331
Cdd:pfam03982 161 HTLTLKNRKGFVRIALKTGADLVPVYSFGENDVYKQWENPEGSRLRWVQEKLKRAIGFSPPIFHGRGVFNSYTFGLLPFR 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 16975490   332 KPITTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN 388
Cdd:pfam03982 241 KPITTVVGAPIEVTKTLNPTQEQIDELHGQYMEALRELFEEHKTKFGVPPDTDLVLN 297
 
Name Accession Description Interval E-value
DAGAT pfam03982
Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is ...
92-388 0e+00

Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is catalyzed by the enzyme diacylglycerol acyltransferase (DAGAT).


Pssm-ID: 112781 [Multi-domain]  Cd Length: 297  Bit Score: 524.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490    92 MYTFCTDCWLIAVLYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAF 171
Cdd:pfam03982   1 FVLFFTPQWSLLVLYALWLFYDWNSPKRGGYRSNWARNWRIWKWFANYFPVKLHKTAELPPNRNYLFGYHPHGILSVGAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   172 CNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGK 251
Cdd:pfam03982  81 SNFSTNATGFMDKFPGIRPNICTLAGQFYTPFRREILLSLGLIEVSRESIEYVLDKCGKGRAVVLVVGGAAEALEAHPGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   252 NAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYS 331
Cdd:pfam03982 161 HTLTLKNRKGFVRIALKTGADLVPVYSFGENDVYKQWENPEGSRLRWVQEKLKRAIGFSPPIFHGRGVFNSYTFGLLPFR 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 16975490   332 KPITTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN 388
Cdd:pfam03982 241 KPITTVVGAPIEVTKTLNPTQEQIDELHGQYMEALRELFEEHKTKFGVPPDTDLVLN 297
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
136-375 7.49e-57

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 185.18  E-value: 7.49e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490 136 FRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGL-GAFCNFsteatEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGIC 214
Cdd:cd07987   1 HRKYFRVYEVRGLENIPDEGPALLVHPHGGLPIdGALLAA-----AFLLLFPGRLPRALADHFLFPLPGLRDLLRRLGAV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490 215 PVNRDTIDYLLSKngsGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGS 294
Cdd:cd07987  76 PGSRENCVRLLRE---GELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDPDGP 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490 295 WGRWvqkkfqkyigfapcifHGRGLfssdtwgLVPYSKPITTVVGEPITVPKLE--HPTQKDIDLYHAMYMEALVKLFDN 372
Cdd:cd07987 153 VGKR----------------LFRLL-------PLPRRLPLYPVFGEPIVVPRPPipDPPDEDVEELHQKYIAALRELIEK 209

                ...
gi 16975490 373 HKT 375
Cdd:cd07987 210 HKK 212
PLN02783 PLN02783
diacylglycerol O-acyltransferase
72-383 4.24e-48

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 165.56  E-value: 4.24e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   72 SVLQWVLSFLVLG----VACSVILMYTFCTDCWLIAVLYFtWLAFDW----NTPKKGGRRSQWVRnwavwRYFRDYFPIQ 143
Cdd:PLN02783  15 SVLSILAVAIWLGaihfNVALVLASLFFLPSPVALTVLAL-LLLLMFipahPTSKLGRKIARFIC-----KYACAYFPVR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490  144 LVKT--HNLLTTRNYIFGYHPHGIM--GLGAFCNFSteatevskKF---PGIRPyLATLAgNFRMPVLREYLMSGGICPV 216
Cdd:PLN02783  89 LHVEdeEAFDPNRAYVFGYEPHSVLpiGVIALADLS--------GFlplPKIRA-LASSA-VFYTPFLRHIWTWLGLDPA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490  217 NRDTIDYLLSKngsGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKqvifeegsW- 295
Cdd:PLN02783 159 SRKNFTSLLKA---GYSCIIVPGGVQECLYMEHGSEVAYLKSRKGFVKIAMETGAPLVPVFCFGQTRAYK--------Ww 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490  296 ---GRWVQkKFQKYIGFAPCIFHGRglfssdtWGL-VPYSKPITTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFD 371
Cdd:PLN02783 228 kpgGPLVP-KLSRAIGFTPIVFWGR-------YGSpIPHRTPMHVVVGKPIEVKKNPQPSQEEVAEVLEQFVEALQDLFE 299
                        330
                 ....*....|..
gi 16975490  372 NHKTKFGLPETE 383
Cdd:PLN02783 300 KHKARAGYGDLE 311
 
Name Accession Description Interval E-value
DAGAT pfam03982
Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is ...
92-388 0e+00

Diacylglycerol acyltransferase; The terminal step of triacylglycerol (TAG) formation is catalyzed by the enzyme diacylglycerol acyltransferase (DAGAT).


Pssm-ID: 112781 [Multi-domain]  Cd Length: 297  Bit Score: 524.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490    92 MYTFCTDCWLIAVLYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAF 171
Cdd:pfam03982   1 FVLFFTPQWSLLVLYALWLFYDWNSPKRGGYRSNWARNWRIWKWFANYFPVKLHKTAELPPNRNYLFGYHPHGILSVGAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   172 CNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGK 251
Cdd:pfam03982  81 SNFSTNATGFMDKFPGIRPNICTLAGQFYTPFRREILLSLGLIEVSRESIEYVLDKCGKGRAVVLVVGGAAEALEAHPGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   252 NAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYS 331
Cdd:pfam03982 161 HTLTLKNRKGFVRIALKTGADLVPVYSFGENDVYKQWENPEGSRLRWVQEKLKRAIGFSPPIFHGRGVFNSYTFGLLPFR 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 16975490   332 KPITTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN 388
Cdd:pfam03982 241 KPITTVVGAPIEVTKTLNPTQEQIDELHGQYMEALRELFEEHKTKFGVPPDTDLVLN 297
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
136-375 7.49e-57

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 185.18  E-value: 7.49e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490 136 FRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGL-GAFCNFsteatEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGIC 214
Cdd:cd07987   1 HRKYFRVYEVRGLENIPDEGPALLVHPHGGLPIdGALLAA-----AFLLLFPGRLPRALADHFLFPLPGLRDLLRRLGAV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490 215 PVNRDTIDYLLSKngsGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGS 294
Cdd:cd07987  76 PGSRENCVRLLRE---GELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDPDGP 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490 295 WGRWvqkkfqkyigfapcifHGRGLfssdtwgLVPYSKPITTVVGEPITVPKLE--HPTQKDIDLYHAMYMEALVKLFDN 372
Cdd:cd07987 153 VGKR----------------LFRLL-------PLPRRLPLYPVFGEPIVVPRPPipDPPDEDVEELHQKYIAALRELIEK 209

                ...
gi 16975490 373 HKT 375
Cdd:cd07987 210 HKK 212
PLN02783 PLN02783
diacylglycerol O-acyltransferase
72-383 4.24e-48

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 165.56  E-value: 4.24e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490   72 SVLQWVLSFLVLG----VACSVILMYTFCTDCWLIAVLYFtWLAFDW----NTPKKGGRRSQWVRnwavwRYFRDYFPIQ 143
Cdd:PLN02783  15 SVLSILAVAIWLGaihfNVALVLASLFFLPSPVALTVLAL-LLLLMFipahPTSKLGRKIARFIC-----KYACAYFPVR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490  144 LVKT--HNLLTTRNYIFGYHPHGIM--GLGAFCNFSteatevskKF---PGIRPyLATLAgNFRMPVLREYLMSGGICPV 216
Cdd:PLN02783  89 LHVEdeEAFDPNRAYVFGYEPHSVLpiGVIALADLS--------GFlplPKIRA-LASSA-VFYTPFLRHIWTWLGLDPA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490  217 NRDTIDYLLSKngsGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKqvifeegsW- 295
Cdd:PLN02783 159 SRKNFTSLLKA---GYSCIIVPGGVQECLYMEHGSEVAYLKSRKGFVKIAMETGAPLVPVFCFGQTRAYK--------Ww 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490  296 ---GRWVQkKFQKYIGFAPCIFHGRglfssdtWGL-VPYSKPITTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFD 371
Cdd:PLN02783 228 kpgGPLVP-KLSRAIGFTPIVFWGR-------YGSpIPHRTPMHVVVGKPIEVKKNPQPSQEEVAEVLEQFVEALQDLFE 299
                        330
                 ....*....|..
gi 16975490  372 NHKTKFGLPETE 383
Cdd:PLN02783 300 KHKARAGYGDLE 311
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
161-289 8.51e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 37.23  E-value: 8.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16975490 161 HPHGIM-GLgAFCNFSTEatevskkfpgIRPYLATLAgNFRMPVLREylMSGGICPV-----------NRDTIDYLLSKN 228
Cdd:cd07986  30 HPFGILdGL-ILADLLGS----------VRPDVRILA-NQLLSKIPE--LRDLFIPVdplegraalakNRESLREALRHL 95
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16975490 229 GSGNAIIIVVGGAAeSLSSMPGKNAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVI 289
Cdd:cd07986  96 KNGGALIIFPAGRV-STASPPFGRVSDRPWNPFVARLARKAKAPVVPVYFSGRNSRLFYLA 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH