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    pdia2.L protein disulfide isomerase family A member 2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399040, updated on 4-Nov-2024

    Summary

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    Official Symbol
    pdia2.L
    Official Full Name
    protein disulfide isomerase family A member 2 L homeolog
    Primary source
    Xenbase:XB-GENE-5770864
    Locus tag
    XELAEV_18045582mg
    See related
    EnsemblRapid:ENSXLAG00005035093 AllianceGenome:Xenbase:XB-GENE-5770864
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    pdi; pdip; XPDIp; pdia2
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to act upstream of or within protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Is expressed in endoderm. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pdia2.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (122960234..122977432, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (112331248..112348515, complement)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene myosin phosphatase Rho interacting protein L homeolog Neighboring gene axin 1 L homeolog Neighboring gene Rho GDP dissociation inhibitor (GDI) gamma L homeolog Neighboring gene regulator of G-protein signaling 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pancreatic protein disulfide isomerase (XPDIp) is an early marker for the exocrine lineage of the developing pancreas in Xenopus laevis embryos. Afelik S, et al. Gene Expr Patterns, 2004 Jan. PMID 14678831
    2. Screening for novel pancreatic genes from in vitro-induced pancreas in Xenopus. Sogame A, et al. Dev Growth Differ, 2003 Apr. PMID 12752502
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide isomerase family A member 2 L homeolog
    Names
    pancreas-specific protein disulfide isomerase
    protein disulfide isomerase A2
    protein disulfide isomerase family A, member 2
    NP_001083648.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090179.1 → NP_001083648.1  protein disulfide isomerase family A member 2 L homeolog precursor

      See identical proteins and their annotated locations for NP_001083648.1

      Status: PROVISIONAL

      Source sequence(s)
      AY351916
      UniProtKB/TrEMBL
      A0A974C0S6, Q6V4H6
      Related
      ENSXLAP00005104886.1, ENSXLAT00005106927.1
      Conserved Domains (5) summary
      cd02961
      Location:49 → 151
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      cd02981
      Location:159 → 257
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:280 → 370
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:391 → 493
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      TIGR01130
      Location:46 → 502
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      122960234..122977432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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