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    CLOCK clock circadian regulator [ Homo sapiens (human) ]

    Gene ID: 9575, updated on 2-Nov-2024

    Summary

    Official Symbol
    CLOCKprovided by HGNC
    Official Full Name
    clock circadian regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:2082
    See related
    Ensembl:ENSG00000134852 MIM:601851; AllianceGenome:HGNC:2082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAT13D; bHLHe8
    Summary
    The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 6.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CLOCK in Genome Data Viewer
    Location:
    4q12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (55427903..55546909, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (58916047..59035037, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56294070..56413076, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:56230743-56231431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:56231432-56232119 Neighboring gene steroid 5 alpha-reductase 3 Neighboring gene SRD5A3 antisense RNA 1 Neighboring gene FCF1 pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 2928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21574 Neighboring gene transmembrane protein 165 Neighboring gene Sharpr-MPRA regulatory region 15506 Neighboring gene Sharpr-MPRA regulatory region 12160 Neighboring gene uncharacterized LOC124900704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15442 Neighboring gene RN7SK pseudogene 30 Neighboring gene phosducin like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15443 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501035-56501786 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501787-56502538 Neighboring gene neuromedin U

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of clock homolog (mouse, CLOCK) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ39000, FLJ42446, KIAA0334, DKFZp686I23208

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of glucocorticoid receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in photoperiodism TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of hair cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of type B pancreatic cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to redox state IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of CLOCK-BMAL transcription complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CLOCK-BMAL transcription complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in chromatoid body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    circadian locomoter output cycles protein kaput
    Names
    circadian locomoter output cycles kaput protein
    class E basic helix-loop-helix protein 8
    clock homolog
    NP_001254772.1
    NP_004889.1
    XP_005265844.1
    XP_011532712.1
    XP_011532713.1
    XP_016864343.1
    XP_024310052.1
    XP_047272387.1
    XP_047272388.1
    XP_047272389.1
    XP_047272390.1
    XP_047272391.1
    XP_047272392.1
    XP_047272393.1
    XP_047272394.1
    XP_047272395.1
    XP_047272396.1
    XP_054207263.1
    XP_054207264.1
    XP_054207265.1
    XP_054207266.1
    XP_054207267.1
    XP_054207268.1
    XP_054207269.1
    XP_054207270.1
    XP_054207271.1
    XP_054207272.1
    XP_054207273.1
    XP_054207274.1
    XP_054207275.1
    XP_054207276.1
    XP_054207277.1
    XP_054207278.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267843.2NP_001254772.1  circadian locomoter output cycles protein kaput

      See identical proteins and their annotated locations for NP_001254772.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC069200, BC041878
      Consensus CDS
      CCDS3500.1
      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
      UniProtKB/TrEMBL
      Q3ZCT4, Q53EU0
      Related
      ENSP00000370723.1, ENST00000381322.5
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    2. NM_004898.4NP_004889.1  circadian locomoter output cycles protein kaput

      See identical proteins and their annotated locations for NP_004889.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC069200, AK223549, DA658950
      Consensus CDS
      CCDS3500.1
      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
      UniProtKB/TrEMBL
      Q3ZCT4, Q53EU0
      Related
      ENSP00000426983.1, ENST00000513440.6
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      55427903..55546909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534410.3XP_011532712.1  circadian locomoter output cycles protein kaput isoform X1

      See identical proteins and their annotated locations for XP_011532712.1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
      UniProtKB/TrEMBL
      Q3ZCT4, Q53EU0
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    2. XM_047416432.1XP_047272388.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    3. XM_047416436.1XP_047272392.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    4. XM_017008854.2XP_016864343.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
      UniProtKB/TrEMBL
      Q3ZCT4, Q53EU0
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    5. XM_047416433.1XP_047272389.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    6. XM_011534411.3XP_011532713.1  circadian locomoter output cycles protein kaput isoform X1

      See identical proteins and their annotated locations for XP_011532713.1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
      UniProtKB/TrEMBL
      Q3ZCT4, Q53EU0
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    7. XM_047416439.1XP_047272395.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    8. XM_047416437.1XP_047272393.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    9. XM_005265787.3XP_005265844.1  circadian locomoter output cycles protein kaput isoform X1

      See identical proteins and their annotated locations for XP_005265844.1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
      UniProtKB/TrEMBL
      Q3ZCT4, Q53EU0
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    10. XM_047416431.1XP_047272387.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    11. XM_047416434.1XP_047272390.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    12. XM_047416435.1XP_047272391.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    13. XM_024454284.2XP_024310052.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
      UniProtKB/TrEMBL
      Q3ZCT4, Q53EU0
      Conserved Domains (4) summary
      cd00083
      Location:3286
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam00989
      Location:109175
      PAS; PAS fold
      pfam09606
      Location:496686
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl25986
      Location:274377
      PAS_3; PAS fold
    14. XM_047416438.1XP_047272394.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    15. XM_047416440.1XP_047272396.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      58916047..59035037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351289.1XP_054207264.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    2. XM_054351290.1XP_054207265.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    3. XM_054351294.1XP_054207269.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    4. XM_054351288.1XP_054207263.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    5. XM_054351292.1XP_054207267.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    6. XM_054351297.1XP_054207272.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    7. XM_054351301.1XP_054207276.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    8. XM_054351296.1XP_054207271.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    9. XM_054351293.1XP_054207268.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    10. XM_054351295.1XP_054207270.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    11. XM_054351300.1XP_054207275.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    12. XM_054351302.1XP_054207277.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    13. XM_054351291.1XP_054207266.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    14. XM_054351299.1XP_054207274.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    15. XM_054351298.1XP_054207273.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8
    16. XM_054351303.1XP_054207278.1  circadian locomoter output cycles protein kaput isoform X1

      UniProtKB/Swiss-Prot
      A0AV01, A2I2N9, O14516, O15516, Q9UIT8