letm1 leucine zipper-EF-hand containing transmembrane protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: letm1provided by ZNC
Official Full Name: leucine zipper-EF-hand containing transmembrane protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-154
See related: Ensembl:ENSDARG00000056978 AllianceGenome:ZFIN:ZDB-GENE-050522-154
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: KHE; fc31h08; fc58h01; wu:fc31h08; wu:fc58h01; zgc:109969
Summary: Predicted to enable calcium:proton antiporter activity. Predicted to be involved in cellular calcium ion homeostasis and protein complex oligomerization. Predicted to act upstream of or within calcium ion transport. Predicted to be located in mitochondrial inner membrane. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (13033821..13102879)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (12901362..12970404)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish.
Title: The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk79e10.x1 (e-PCR)
- UniSTS:201544

fc31h08.x1 (e-PCR)
- UniSTS:187977

fk88f04.x1 (e-PCR)
- UniSTS:201668

fc58h01 (e-PCR)
- UniSTS:189433

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium export from the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in inner mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial proton/calcium exchanger protein; LETM1 and EF-hand domain-containing protein 1, mitochondrial

Names: electroneutral mitochondrial K(+)/H(+)exchanger; let-m1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045208.1 → NP_001038673.1 mitochondrial proton/calcium exchanger protein

Status: PROVISIONAL

Source sequence(s)

BX119973

UniProtKB/Swiss-Prot

B8JIA3, Q1LY46

Related

ENSDARP00000074011.5, ENSDART00000079558.7

Conserved Domains (3) summary

pfam07766
Location:162 → 417

LETM1; LETM1-like protein

cl01888
Location:579 → 639

DUF883; Bacterial protein of unknown function (DUF883)

cl23750
Location:473 → 604

vATP-synt_E; ATP synthase (E/31 kDa) subunit

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

13033821..13102879

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009307180.2 → XP_009305455.1 LETM1 and EF-hand domain-containing protein 1, mitochondrial isoform X1

UniProtKB/Swiss-Prot

B8JIA3, Q1LY46

UniProtKB/TrEMBL

A0A8M3AYY0

Conserved Domains (2) summary

pfam07766
Location:162 → 417

LETM1; LETM1-like protein

cl01888
Location:590 → 650

DUF883; Bacterial protein of unknown function (DUF883)
XM_009307181.2 → XP_009305456.1 LETM1 and EF-hand domain-containing protein 1, mitochondrial isoform X2

UniProtKB/Swiss-Prot

B8JIA3, Q1LY46

UniProtKB/TrEMBL

A0A8M3BEI6

Conserved Domains (2) summary

pfam07766
Location:162 → 417

LETM1; LETM1-like protein

cl01888
Location:590 → 650

DUF883; Bacterial protein of unknown function (DUF883)
XM_005156569.3 → XP_005156626.1 LETM1 and EF-hand domain-containing protein 1, mitochondrial isoform X3

UniProtKB/Swiss-Prot

B8JIA3, Q1LY46

UniProtKB/TrEMBL

A0A8M2B3G3

Conserved Domains (3) summary

pfam07766
Location:162 → 417

LETM1; LETM1-like protein

cl01888
Location:579 → 639

DUF883; Bacterial protein of unknown function (DUF883)

cl23750
Location:473 → 604

vATP-synt_E; ATP synthase (E/31 kDa) subunit
XM_009307182.2 → XP_009305457.1 LETM1 and EF-hand domain-containing protein 1, mitochondrial isoform X4

UniProtKB/Swiss-Prot

B8JIA3, Q1LY46

UniProtKB/TrEMBL

A0A8M3AYW7

Conserved Domains (2) summary

pfam07766
Location:162 → 417

LETM1; LETM1-like protein

cl01888
Location:590 → 650

DUF883; Bacterial protein of unknown function (DUF883)