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Conserved domains on  [gi|113680846|ref|NP_001038673|]
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mitochondrial proton/calcium exchanger protein [Danio rerio]

Protein Classification

LETM1/MDM38 family protein( domain architecture ID 10544245)

LETM1/MDM38 family protein similar to mammalian mitochondrial proton/calcium exchanger protein (LETM1) and fungal YLH47/MDM38

Gene Ontology:  GO:0005743|GO:0005739|GO:0043022|GO:0034220
PubMed:  15138253

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 198-429 1.05e-121

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


:

Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 364.11  E-value: 1.05e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  198 LSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEE 277
Cdd:pfam07766   1 LTRREREQLRRTTRDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  278 IAlrnKASKGNVTEEFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIM 357
Cdd:pfam07766  81 SL---SDETTELKEEFKEFFKKVRSGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRH 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113680846  358 KLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMF 429
Cdd:pfam07766 158 KLLEIKRDDRAIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 422-644 5.69e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 422 LLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEK 501
Cdd:COG4942    4 LLLLALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 502 AKEQTQSQEAEVLEVEGERRVDAEHAL---------SSVDVAIHSETLRDTAPVLEGIKG-EEITKEEIDMLSDACTKLK 571
Cdd:COG4942   84 ELAELEKEIAELRAELEAQKEELAELLralyrlgrqPPLALLLSPEDFLDAVRRLQYLKYlAPARREQAEELRADLAELA 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113680846 572 EQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVEESKASQRLsKRVNRMIGRMDKIITELEKD 644
Cdd:COG4942  164 ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAEL-AELQQEAEELEALIARLEAE 235
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 198-429 1.05e-121

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 364.11  E-value: 1.05e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  198 LSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEE 277
Cdd:pfam07766   1 LTRREREQLRRTTRDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  278 IAlrnKASKGNVTEEFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIM 357
Cdd:pfam07766  81 SL---SDETTELKEEFKEFFKKVRSGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRH 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113680846  358 KLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMF 429
Cdd:pfam07766 158 KLLEIKRDDRAIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 422-644 5.69e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 422 LLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEK 501
Cdd:COG4942    4 LLLLALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 502 AKEQTQSQEAEVLEVEGERRVDAEHAL---------SSVDVAIHSETLRDTAPVLEGIKG-EEITKEEIDMLSDACTKLK 571
Cdd:COG4942   84 ELAELEKEIAELRAELEAQKEELAELLralyrlgrqPPLALLLSPEDFLDAVRRLQYLKYlAPARREQAEELRADLAELA 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113680846 572 EQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVEESKASQRLsKRVNRMIGRMDKIITELEKD 644
Cdd:COG4942  164 ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAEL-AELQQEAEELEALIARLEAE 235
PTZ00121 PTZ00121
MAEBL; Provisional
 453-645 1.08e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  453 KEAQVKVAElDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEAEVLEV----EGERRVDAEHAL 528
Cdd:PTZ00121 1535 KADEAKKAE-EKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVmklyEEEKKMKAEEAK 1613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  529 SSVDVAIHSETLRDTAPVLEGI------------KGEEITKEEidmlSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSE 596
Cdd:PTZ00121 1614 KAEEAKIKAEELKKAEEEKKKVeqlkkkeaeekkKAEELKKAE----EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 113680846  597 DLEEIKRELSKTGQ-----EKAVEESKASQRLSKRVNRMIGRMDKIITELEKDK 645
Cdd:PTZ00121 1690 AAEALKKEAEEAKKaeelkKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK 1743
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 454-632 1.59e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   454 EAQVKVAELDFSKVDNK-TKLETTLQEEAAIR-------QENRERELERLADAAEKAKE-----QTQSQEAEVLEVEGER 520
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEiEELEREIEEERKRRdklteeyAELKEELEDLRAELEEVDKEfaetrDELKDYREKLEKLKRE 400

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   521 RVDAEHALSSVDVAIH--SETLRDTAPVLEGIKG-----EEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQE 593
Cdd:TIGR02169  401 INELKRELDRLQEELQrlSEELADLNAAIAGIEAkinelEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDR 480

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 113680846   594 YSEDLEEIKRELSKTgqEKAVEESKASQRLSKRVNRMIG 632
Cdd:TIGR02169  481 VEKELSKLQRELAEA--EAQARASEERVRGGRAVEEVLK 517
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 483-647 1.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  483 IRQENRERELERLADaAEKAKEQTQSQEAEVLEVEGERRVD-AEHALSSVDVAIHSETLRDTAPVLEGIKGEEITKEEID 561
Cdd:pfam17380 353 IRQEERKRELERIRQ-EEIAMEISRMRELERLQMERQQKNErVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEE 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  562 MLSDACTKLKEQKnlltkeKEELEDLKDDVQEYSEDLEEIKRELSKTGQEK-AVEESKASQRLSKRVNRMI------GRM 634
Cdd:pfam17380 432 ARQREVRRLEEER------AREMERVRLEEQERQQQVERLRQQEEERKRKKlELEKEKRDRKRAEEQRRKIlekeleERK 505

                         170
                  ....*....|...
gi 113680846  635 DKIITELEKDKMV 647
Cdd:pfam17380 506 QAMIEEERKRKLL 518
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 198-429 1.05e-121

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 364.11  E-value: 1.05e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  198 LSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQSKKEERLKKELRVKLEMAKFLQDTIEE 277
Cdd:pfam07766   1 LTRREREQLRRTTRDLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  278 IAlrnKASKGNVTEEFSTFFQKIRDSGEIPSNEQIIRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLIM 357
Cdd:pfam07766  81 SL---SDETTELKEEFKEFFKKVRSGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRH 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113680846  358 KLRAIRADDKLIAEEGVDSLTANELQAACRVRGMRALGVTEERLREQLKQWLELHLNQHIPTSLLLLSRAMF 429
Cdd:pfam07766 158 KLLEIKRDDRAIAREGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 422-644 5.69e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 422 LLLSRAMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEK 501
Cdd:COG4942    4 LLLLALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 502 AKEQTQSQEAEVLEVEGERRVDAEHAL---------SSVDVAIHSETLRDTAPVLEGIKG-EEITKEEIDMLSDACTKLK 571
Cdd:COG4942   84 ELAELEKEIAELRAELEAQKEELAELLralyrlgrqPPLALLLSPEDFLDAVRRLQYLKYlAPARREQAEELRADLAELA 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113680846 572 EQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVEESKASQRLsKRVNRMIGRMDKIITELEKD 644
Cdd:COG4942  164 ALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAEL-AELQQEAEELEALIARLEAE 235
PTZ00121 PTZ00121
MAEBL; Provisional
 453-645 1.08e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  453 KEAQVKVAElDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEAEVLEV----EGERRVDAEHAL 528
Cdd:PTZ00121 1535 KADEAKKAE-EKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVmklyEEEKKMKAEEAK 1613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  529 SSVDVAIHSETLRDTAPVLEGI------------KGEEITKEEidmlSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSE 596
Cdd:PTZ00121 1614 KAEEAKIKAEELKKAEEEKKKVeqlkkkeaeekkKAEELKKAE----EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 113680846  597 DLEEIKRELSKTGQ-----EKAVEESKASQRLSKRVNRMIGRMDKIITELEKDK 645
Cdd:PTZ00121 1690 AAEALKKEAEEAKKaeelkKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK 1743
PTZ00121 PTZ00121
MAEBL; Provisional
 452-645 4.40e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.44  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  452 AKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQEN-RERELERLADAAEKAKEQTQSQEAEVLEVEGER----RVDAEH 526
Cdd:PTZ00121 1175 AKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEeRKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKaeeeRNNEEI 1254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  527 ALSSVDVAIHSETLRDTAPVLEGIKGEEITKEEIDMLSDACTKLKEQKNL-----LTKEKEELEDLKDDVQEYSEDLEEI 601
Cdd:PTZ00121 1255 RKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKAdeakkKAEEAKKADEAKKKAEEAKKKADAA 1334

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 113680846  602 KR---ELSKTGQEKAVEESKASQRLSKRVNRmiGRMDKIITELEKDK 645
Cdd:PTZ00121 1335 KKkaeEAKKAAEAAKAEAEAAADEAEAAEEK--AEAAEKKKEEAKKK 1379
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
468-643 5.19e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 5.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  468 DNKTKLEtTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEA-EVLEVEGERRVD---AEHALSSVDVAIhsETLRDT 543
Cdd:COG4913   607 DNRAKLA-ALEAELAELEEELAEAEERLEALEAELDALQERREAlQRLAEYSWDEIDvasAEREIAELEAEL--ERLDAS 683

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  544 APVLEGIKGE-EITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVE------- 615
Cdd:COG4913   684 SDDLAALEEQlEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAaalgdav 763

                         170       180
                  ....*....|....*....|....*...
gi 113680846  616 ESKASQRLSKRVNRMIGRMDKIITELEK 643
Cdd:COG4913   764 ERELRENLEERIDALRARLNRAEEELER 791
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 449-623 5.88e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 449 EIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEAEVLEVEGERRvDAEHAL 528
Cdd:COG1196  282 ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE-EAEAEL 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 529 SSVDVAIhSETLRDTAPVLEGIkgEEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKT 608
Cdd:COG1196  361 AEAEEAL-LEAEAELAEAEEEL--EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                        170
                 ....*....|....*
gi 113680846 609 GQEKAVEESKASQRL 623
Cdd:COG1196  438 EEEEEALEEAAEEEA 452
mukB PRK04863
chromosome partition protein MukB;
397-654 7.97e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.49  E-value: 7.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  397 TEERLREQLKQWLEL--HLNQHIPTSLLLLsramflPDTLSPadqlkttlqnlpEIMAKEAQVKVAELDFSKVDNKTKLE 474
Cdd:PRK04863  859 QEQQQRSQLEQAKEGlsALNRLLPRLNLLA------DETLAD------------RVEEIREQLDEAEEAKRFVQQHGNAL 920

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  475 TTLQEEAAIRQENRER--ELERLADAAEKAKEQTQSQEAEVLEVEgERRvdaeHALSSVDVAihsETLRDTAPVLEGIKG 552
Cdd:PRK04863  921 AQLEPIVSVLQSDPEQfeQLKQDYQQAQQTQRDAKQQAFALTEVV-QRR----AHFSYEDAA---EMLAKNSDLNEKLRQ 992

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  553 EEITKEEidMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTG-QEKAVEESKASQR---LSKRVN 628
Cdd:PRK04863  993 RLEQAEQ--ERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDLGvPADSGAEERARARrdeLHARLS 1070

                         250       260
                  ....*....|....*....|....*.
gi 113680846  629 RMIGRmdkiITELEKDKMVLDGQMDS 654
Cdd:PRK04863 1071 ANRSR----RNQLEKQLTFCEAEMDN 1092
PTZ00121 PTZ00121
MAEBL; Provisional
 452-625 1.00e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  452 AKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEA----------EVLEVEGERR 521
Cdd:PTZ00121 1492 AEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELkkaeelkkaeEKKKAEEAKK 1571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  522 V--DAEHALSSVDVAIHSETLRDTAPVLEGIKGEEITKEEIDMLSDACTKLKEQKNlLTKEKEELEDLKDDVQEYSEDLE 599
Cdd:PTZ00121 1572 AeeDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEKKKAE 1650

                         170       180
                  ....*....|....*....|....*.
gi 113680846  600 EIKRELSKTGQEKAVEESKASQRLSK 625
Cdd:PTZ00121 1651 ELKKAEEENKIKAAEEAKKAEEDKKK 1676
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 453-629 1.55e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 453 KEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEAEVLEVEgERRVDAEHALSSVd 532
Cdd:COG1196  220 EELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELE-EAQAEEYELLAEL- 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 533 vaihSETLRDTAPVLEGIKGEEITKEEIDmlsdacTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEK 612
Cdd:COG1196  298 ----ARLEQDIARLEERRRELEERLEELE------EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                        170
                 ....*....|....*..
gi 113680846 613 AVEESKASQRLSKRVNR 629
Cdd:COG1196  368 LEAEAELAEAEEELEEL 384
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 454-632 1.59e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   454 EAQVKVAELDFSKVDNK-TKLETTLQEEAAIR-------QENRERELERLADAAEKAKE-----QTQSQEAEVLEVEGER 520
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEiEELEREIEEERKRRdklteeyAELKEELEDLRAELEEVDKEfaetrDELKDYREKLEKLKRE 400

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   521 RVDAEHALSSVDVAIH--SETLRDTAPVLEGIKG-----EEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQE 593
Cdd:TIGR02169  401 INELKRELDRLQEELQrlSEELADLNAAIAGIEAkinelEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDR 480

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 113680846   594 YSEDLEEIKRELSKTgqEKAVEESKASQRLSKRVNRMIG 632
Cdd:TIGR02169  481 VEKELSKLQRELAEA--EAQARASEERVRGGRAVEEVLK 517
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
453-643 1.63e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.05  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 453 KEAQVKVAELDFSKVDNKTKLETTLQEEAAirqeNRERELERLADAAEKAKEQtqsqEAEVLEVEGERRvDAEHALSSVD 532
Cdd:PRK03918 506 KELEEKLKKYNLEELEKKAEEYEKLKEKLI----KLKGEIKSLKKELEKLEEL----KKKLAELEKKLD-ELEEELAELL 576

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 533 VAIHSETLRDTAPVLEGIKGEEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEK 612
Cdd:PRK03918 577 KELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKY 656

                        170       180       190
                 ....*....|....*....|....*....|.
gi 113680846 613 AVEESKASQRLSKRVNRMIGRMDKIITELEK 643
Cdd:PRK03918 657 SEEEYEELREEYLELSRELAGLRAELEELEK 687
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 470-626 2.06e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 470 KTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEAEVLEVEGERRVdAEHALSSVDVAIHSETLRDTAPVLEG 549
Cdd:COG1196  219 KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEE-LRLELEELELELEEAQAEEYELLAEL 297

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113680846 550 IKGEEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAVEESKASQRLSKR 626
Cdd:COG1196  298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 427-643 2.62e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 427 AMFLPDTLSPADQLKTTLQNLPEIMAKEAQVKvAELDfsKVDNKtkLETTLQEEAAIRQENR--ERELERLADAAEKAKE 504
Cdd:COG3883    5 ALAAPTPAFADPQIQAKQKELSELQAELEAAQ-AELD--ALQAE--LEELNEEYNELQAELEalQAEIDKLQAEIAEAEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 505 QTQSQEAEVleveGERRVDA---EHALSSVDVAIHSETLRDtapVLEGIKG-EEITKEEIDMLSDactkLKEQKNLLTKE 580
Cdd:COG3883   80 EIEERREEL----GERARALyrsGGSVSYLDVLLGSESFSD---FLDRLSAlSKIADADADLLEE----LKADKAELEAK 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113680846 581 KEELEDLKDDVQEYSEDLEEIKRELsktgQEKAVEESKASQRLSKRVNRMIGRMDKIITELEK 643
Cdd:COG3883  149 KAELEAKLAELEALKAELEAAKAEL----EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
454-645 3.36e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.26  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 454 EAQVKVAELDFSKVDNKTKLETTLQE---EAAIRQENRERELERLADAAEKAKEQTQS-----QEAEVLEVEGErrvdaE 525
Cdd:PRK02224 481 EAELEDLEEEVEEVEERLERAEDLVEaedRIERLEERREDLEELIAERRETIEEKRERaeelrERAAELEAEAE-----E 555

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 526 HALSSVDVAIHSETLRDTAPVLEGIKGEeiTKEEIDMLSDACTKLKEQKNL------LTKEKEELEDLKDDVQEYSEDLE 599
Cdd:PRK02224 556 KREAAAEAEEEAEEAREEVAELNSKLAE--LKERIESLERIRTLLAAIADAedeierLREKREALAELNDERRERLAEKR 633

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 113680846 600 EIKRELSKTGQEKAVEESKASQrlsKRVNRMIGRMDKIITELEKDK 645
Cdd:PRK02224 634 ERKRELEAEFDEARIEEAREDK---ERAEEYLEQVEEKLDELREER 676
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
490-629 4.58e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  490 RELERLADAAEKAKEQtqsqeAEVLEVEGERRVDAEHALSSVDVAihsETLRDTAPVLEGIKGEEITKEEIDMLSDACTK 569
Cdd:COG4913   235 DDLERAHEALEDAREQ-----IELLEPIRELAERYAAARERLAEL---EYLRAALRLWFAQRRLELLEAELEELRAELAR 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113680846  570 LKEQKNLLTKEKEELEDLKDDVQEY-----SEDLEEIKRELSKTGQEKAvEESKASQRLSKRVNR 629
Cdd:COG4913   307 LEAELERLEARLDALREELDELEAQirgngGDRLEQLEREIERLERELE-ERERRRARLEALLAA 370
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 441-709 7.20e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.50  E-value: 7.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   441 KTTLQNLPEIMAKEAQVKVAELDFSK--VDNKTKLettLQEEAAIrqenrERELERLADAAEKAKEQTQSQEAEVLEVEG 518
Cdd:TIGR01612 1161 KAISNDDPEEIEKKIENIVTKIDKKKniYDEIKKL---LNEIAEI-----EKDKTSLEEVKGINLSYGKNLGKLFLEKID 1232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   519 ERRVDAEHALSSVDVAIHS-ETLRDTAPVLEGIKGEEI-TKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDD----VQ 592
Cdd:TIGR01612 1233 EEKKKSEHMIKAMEAYIEDlDEIKEKSPEIENEMGIEMdIKAEMETFNISHDDDKDHHIISKKHDENISDIREKslkiIE 1312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   593 EYSE--DLEEIKRELSKTGQEKAVEESKASQRLSKRVNRM-IGRMDKIITELEKDKmvldgqmdsETTPPIGENLISIN- 668
Cdd:TIGR01612 1313 DFSEesDINDIKKELQKNLLDAQKHNSDINLYLNEIANIYnILKLNKIKKIIDEVK---------EYTKEIEENNKNIKd 1383

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 113680846   669 ELITVMKQIQNIPEH-KLLSIADALDENKDGKiDIDDVIKVV 709
Cdd:TIGR01612 1384 ELDKSEKLIKKIKDDiNLEECKSKIESTLDDK-DIDECIKKI 1424
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 487-642 7.57e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 7.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   487 NRERELERLADAAEKAKEQTQSQEAEVLEVEGERRvDAEHALSSVDVAIHSET--LRDTAPVLEGIKGEEITKEE-IDML 563
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKELE-ELEEELEQLRKELEELSrqISALRKDLARLEAEVEQLEErIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   564 SDACTKLKEQKNLLTKEKEEL-----------EDLKDDVQEYSEDLEEIKRELSKTgQEKAVEESKASQRLSKRVNRMIG 632
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAeeelaeaeaeiEELEAQIEQLKEELKALREALDEL-RAELTLLNEEAANLRERLESLER 831

                          170
                   ....*....|
gi 113680846   633 RMDKIITELE 642
Cdd:TIGR02168  832 RIAATERRLE 841
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 439-716 8.36e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.70  E-value: 8.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  439 QLKTTLQNLP-EIMAKEAQVKvaELDFSKVDNKTKLETTLQEEAAIRQ--ENRERELERLADAAEKAKEQTQ--SQEAEV 513
Cdd:TIGR04523 437 KNNSEIKDLTnQDSVKELIIK--NLDNTRESLETQLKVLSRSINKIKQnlEQKQKELKSKEKELKKLNEEKKelEEKVKD 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  514 LEVEGERRVDAEHALSSVDVAIHSE--TLRDTAPVLEGIKGEEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLkddV 591
Cdd:TIGR04523 515 LTKKISSLKEKIEKLESEKKEKESKisDLEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQEL---I 591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  592 QEYSEDLEEIKRELSKtgQEKAVEESKASQRLSKRVNRmigRMDKIITELEKDKmvldgqmdsettppigenlisiNELI 671
Cdd:TIGR04523 592 DQKEKEKKDLIKEIEE--KEKKISSLEKELEKAKKENE---KLSSIIKNIKSKK----------------------NKLK 644

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 113680846  672 TVMKQIQNIPEHKLLSIADALDENKDGKIDIDDVIKVVELIDKED 716
Cdd:TIGR04523 645 QEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKEL 689
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 483-647 1.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  483 IRQENRERELERLADaAEKAKEQTQSQEAEVLEVEGERRVD-AEHALSSVDVAIHSETLRDTAPVLEGIKGEEITKEEID 561
Cdd:pfam17380 353 IRQEERKRELERIRQ-EEIAMEISRMRELERLQMERQQKNErVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEE 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  562 MLSDACTKLKEQKnlltkeKEELEDLKDDVQEYSEDLEEIKRELSKTGQEK-AVEESKASQRLSKRVNRMI------GRM 634
Cdd:pfam17380 432 ARQREVRRLEEER------AREMERVRLEEQERQQQVERLRQQEEERKRKKlELEKEKRDRKRAEEQRRKIlekeleERK 505

                         170
                  ....*....|...
gi 113680846  635 DKIITELEKDKMV 647
Cdd:pfam17380 506 QAMIEEERKRKLL 518
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
469-645 1.60e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.97  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 469 NKTKLETTLQEEAAIRQENRE-----RELERLADAAEKAKEQTQSQEAEVLEVEGERRvDAEHALSSVDVAI-----HSE 538
Cdd:PRK03918 198 KEKELEEVLREINEISSELPElreelEKLEKEVKELEELKEEIEELEKELESLEGSKR-KLEEKIRELEERIeelkkEIE 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 539 TLRDTAPVLEGIKGEEI-----------TKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSK 607
Cdd:PRK03918 277 ELEEKVKELKELKEKAEeyiklsefyeeYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEE 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 113680846 608 -TGQEKAVEESKAS----QRLSKRV-NRMIGRMDKIITELEKDK 645
Cdd:PRK03918 357 lEERHELYEEAKAKkeelERLKKRLtGLTPEKLEKELEELEKAK 400
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 457-627 4.31e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.52  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 457 VKVAELDFSKVDNKTKLETTLQEEAAIRQE--NRERELERLADAAEKAKEQTQSQEAEVLEVEgERRVDAEHALSSVdva 534
Cdd:COG1579   10 LDLQELDSELDRLEHRLKELPAELAELEDElaALEARLEAAKTELEDLEKEIKRLELEIEEVE-ARIKKYEEQLGNV--- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 535 ihsETLRDtapvLEGIKGE-EITKEEIDMLSDACTKLKEQ----KNLLTKEKEELEDLKDDVQEYSEDLEEIKRELSKTG 609
Cdd:COG1579   86 ---RNNKE----YEALQKEiESLKRRISDLEDEILELMERieelEEELAELEAELAELEAELEEKKAELDEELAELEAEL 158

                        170
                 ....*....|....*...
gi 113680846 610 QEKAVEESKASQRLSKRV 627
Cdd:COG1579  159 EELEAEREELAAKIPPEL 176
PTZ00121 PTZ00121
MAEBL; Provisional
 452-684 4.69e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  452 AKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLADAAEKAKEQTQSQEAEVLEVEGERRVDAEHALSSV 531
Cdd:PTZ00121 1400 AEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKA 1479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  532 DVAIHSETLRDTAPVLEGIKGEEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSE--DLEEIKR--ELSK 607
Cdd:PTZ00121 1480 EEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEkkKADELKKaeELKK 1559

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113680846  608 TGQEKAVEESKasqRLSKRVNrMIGRMDKIITELEKDKMVLDGQMDSETTPPIGENLISINELITVMKQIQNIPEHK 684
Cdd:PTZ00121 1560 AEEKKKAEEAK---KAEEDKN-MALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEK 1632
PTZ00121 PTZ00121
MAEBL; Provisional
 452-646 5.11e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  452 AKEAQVKVAEL----DFSKVDNKTKLETTLQ-EEAAIRQENRERELERLADAAEKAKEQTQSQE--------------AE 512
Cdd:PTZ00121 1505 AAEAKKKADEAkkaeEAKKADEAKKAEEAKKaDEAKKAEEKKKADELKKAEELKKAEEKKKAEEakkaeedknmalrkAE 1584

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  513 VLEVEGERRVDAEHALSSVDVAIHSETLRDTAPvlEGIKGEEITKEE-----IDMLSDACTKLKEQKNLLTKEKEEL--- 584
Cdd:PTZ00121 1585 EAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE--AKIKAEELKKAEeekkkVEQLKKKEAEEKKKAEELKKAEEENkik 1662

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 113680846  585 -EDLKDDVQEYSEDLEEIKR--ELSKTGQE---KAVEESKASQRLSKRVNRMIGRMDKIITELEKDKM 646
Cdd:PTZ00121 1663 aAEEAKKAEEDKKKAEEAKKaeEDEKKAAEalkKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKI 1730
PTZ00121 PTZ00121
MAEBL; Provisional
 441-625 5.24e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  441 KTTLQNLPEIMAKEAQVKVAElDFSKVDNKTKLETTLQ-EEAAIRQENRERELERLADAAEKAKEQTQSQEA-------- 511
Cdd:PTZ00121 1105 KTETGKAEEARKAEEAKKKAE-DARKAEEARKAEDARKaEEARKAEDAKRVEIARKAEDARKAEEARKAEDAkkaeaark 1183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  512 --------EVLEVEGERRVDAEHALSSVDVAIHSETLRDTAPVLEGIKGEEITKEEidmlSDACTKLKEQKNLLTKEKEE 583
Cdd:PTZ00121 1184 aeevrkaeELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDA----EEAKKAEEERNNEEIRKFEE 1259

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 113680846  584 LEDLKDDVQEYSEDLEEIKR--ELSKTGQEKAVEESKASQRLSK 625
Cdd:PTZ00121 1260 ARMAHFARRQAAIKAEEARKadELKKAEEKKKADEAKKAEEKKK 1303
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 437-637 5.25e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.43  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   437 ADQLKTTLQNLPEIMAkEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQE--NRERELERLADAAEKAKEQTQSQEAEVL 514
Cdd:TIGR02168  735 LARLEAEVEQLEERIA-QLSKELTELEAEIEELEERLEEAEEELAEAEAEieELEAQIEQLKEELKALREALDELRAELT 813

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846   515 EVEGERRVDAEHALSSV-DVAIHSETLRDTAPVLEGIKGE-EITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQ 592
Cdd:TIGR02168  814 LLNEEAANLRERLESLErRIAATERRLEDLEEQIEELSEDiESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 113680846   593 EYSEDLEEIKRELSKtgqeKAVEESKASQRLSKRVNRMIGRMDKI 637
Cdd:TIGR02168  894 SELEELSEELRELES----KRSELRRELEELREKLAQLELRLEGL 934
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 449-660 6.46e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 6.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  449 EIMAKEAQVKVAELDFSKVDNKTKLETTLQEEAAIRQENRERELERLadaaeKAKEQTQSQEAEVLEVEGERRVDAEHAL 528
Cdd:pfam17380 405 KILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERV-----RLEEQERQQQVERLRQQEEERKRKKLEL 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846  529 SSVDvaihsetlRDTAPVLEgiKGEEITKEEIDMLSDACTKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRelskt 608
Cdd:pfam17380 480 EKEK--------RDRKRAEE--QRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRK----- 544

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 113680846  609 gqEKAVEESKASQRLSKRVNRMIGRMDKIITELEKDKMVLDG---QMDSETTPPI 660
Cdd:pfam17380 545 --QQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESekaRAEYEATTPI 597
ElaB COG4575
Membrane-anchored ribosome-binding protein ElaB, inhibits growth in stationary phase, YqjD ...
 578-635 7.26e-03

Membrane-anchored ribosome-binding protein ElaB, inhibits growth in stationary phase, YqjD/DUF883 family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 443632 [Multi-domain]  Cd Length: 108  Bit Score: 36.84  E-value: 7.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 113680846 578 TKEKEELEDLKDDVQEYSEDLEEIKRELSKTGQEKAveeSKASQRLSKRVNRMIGRMD 635
Cdd:COG4575    8 TSVEDSKEDLEADLKALVDDLEELLKSTADDAGEKA---AELREKAEAALDEARERLS 62
PRK02292 PRK02292
V-type ATP synthase subunit E; Provisional
 473-604 9.88e-03

V-type ATP synthase subunit E; Provisional


Pssm-ID: 235026 [Multi-domain]  Cd Length: 188  Bit Score: 38.05  E-value: 9.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113680846 473 LETTLQEeaaIRQENRERELERLADAAEKAKEQTQSQEAEVLEVEGERRVDAEHalssvdvaihsetlrdtapvlegikg 552
Cdd:PRK02292   3 LETVVED---IRDEARARASEIRAEADEEAEEIIAEAEADAEEILEDREAEAER-------------------------- 53

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 113680846 553 eEITKEEIDMLSDActKLKEQKNLLTKEKEELEDLKDDVQEYSEDLEEIKRE 604
Cdd:PRK02292  54 -EIEQLREQELSSA--KLEAKRERLNARKEVLEDVRNQVEDEIASLDGDKRE 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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