Rexo4 REX4, 3'-5' exonuclease [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rexo4provided by MGI
Official Full Name: REX4, 3'-5' exonucleaseprovided by MGI
Primary source: MGI:MGI:2684957
See related: Ensembl:ENSMUSG00000052406 AllianceGenome:MGI:2684957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rex4; Gm111; Xpmc2h
Summary: Predicted to enable DNA binding activity and nuclease activity. Predicted to be involved in DNA catabolic process; DNA repair; and RNA processing. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; connective tissue; and genitourinary system. Orthologous to human REXO4 (REX4 homolog, 3'-5' exonuclease). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.6), thymus adult (RPKM 12.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.13 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26843575..26854398, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26953559..26964386, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-31f3 (e-PCR)
- UniSTS:257585

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	ISO Inferred from Sequence Orthology more info
enables exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA exonuclease 4

Names: REX4, RNA exonuclease 4 homolog; XPMC2 prevents mitotic catastrophe 2 homolog; Xenopus prevents mitotic catastrophe 2 homolog; exonuclease XPMC2; prevents mitotic catastrophe 2 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362876.1 → NP_001349805.1 RNA exonuclease 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL773563

UniProtKB/TrEMBL

A2ALB1

Related

ENSMUSP00000121599.2, ENSMUST00000136710.2

Conserved Domains (1) summary

cd06144
Location:254 → 379

REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
NM_207234.2 → NP_997117.2 RNA exonuclease 4 isoform 1

See identical proteins and their annotated locations for NP_997117.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AL773563, BC060147

Consensus CDS

CCDS15819.1

UniProtKB/Swiss-Prot

Q3UU17, Q6PAQ4, Q8C524

UniProtKB/TrEMBL

A2ALB2

Related

ENSMUSP00000109653.4, ENSMUST00000114020.10

Conserved Domains (2) summary

cd06144
Location:254 → 404

REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins

COG0847
Location:251 → 414

DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]

RNA

NR_156410.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL773563