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    Ercc6l2 excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 76251, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ercc6l2provided by MGI
    Official Full Name
    excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2provided by MGI
    Primary source
    MGI:MGI:1923501
    See related
    Ensembl:ENSMUSG00000021470 AllianceGenome:MGI:1923501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sr278; Rad26l; 0610007P08Rik; 1700019D06Rik; 9330134C04Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in cellular response to reactive oxygen species and interstrand cross-link repair. Predicted to be located in mitochondrion and nucleus. Predicted to be part of protein-containing complex. Predicted to colocalize with centrosome. Orthologous to human ERCC6L2 (ERCC excision repair 6 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 2.2), bladder adult (RPKM 2.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ercc6l2 in Genome Data Viewer
    Location:
    13 B3; 13 33.1 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63958793..64048116)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (63810979..63900302)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm702 Neighboring gene predicted gene, 30709 Neighboring gene RIKEN cDNA 1700024I08 gene Neighboring gene STARR-positive B cell enhancer ABC_E7249 Neighboring gene STARR-positive B cell enhancer ABC_E4074 Neighboring gene STARR-positive B cell enhancer ABC_E8531 Neighboring gene STARR-positive B cell enhancer ABC_E5402 Neighboring gene STARR-positive B cell enhancer ABC_E9400 Neighboring gene STARR-positive B cell enhancer ABC_E5403 Neighboring gene STARR-seq mESC enhancer starr_34810 Neighboring gene STARR-seq mESC enhancer starr_34811 Neighboring gene predicted gene, 46423 Neighboring gene STARR-seq mESC enhancer starr_34812 Neighboring gene predicted gene, 30950

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Liu X, et al. Cell Res, 2020 Sep. PMID 32355287, Free PMC Article
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.
      Title: ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC100170

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA excision repair protein ERCC-6-like 2
    Names
    DNA repair and recombination protein RAD26-like
    putative repair and recombination helicase RAD26L
    stretch responsive protein 278

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013608.4 → NP_001013626.2  DNA excision repair protein ERCC-6-like 2 isoform 1

      See identical proteins and their annotated locations for NP_001013626.2

      Status: VALIDATED

      Source sequence(s)
      AC154248
      Consensus CDS
      CCDS26593.2
      UniProtKB/Swiss-Prot
      E9Q4J6, Q6DI94, Q8BIV4, Q8BM40, Q8K267, Q8R2Z6, Q9DA70, Q9DD01, Q9JIM3
      Related
      ENSMUSP00000158755.2, ENSMUST00000238465.2
      Conserved Domains (4) summary
      COG0553
      Location:72 → 649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122 → 369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:1108 → 1131
      VIGSSK; Helicase-associated putative binding domain, C-terminal
      cl02573
      Location:17 → 72
      Tudor_SF; Tudor domain superfamily

    2. NM_001361124.2 → NP_001348053.1  DNA excision repair protein ERCC-6-like 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154248
      UniProtKB/TrEMBL
      A0A589M209
      Related
      ENSMUSP00000021926.7, ENSMUST00000021926.13
      Conserved Domains (1) summary
      COG0553
      Location:81 → 466
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

    3. NM_023507.5 → NP_075996.2  DNA excision repair protein ERCC-6-like 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154248
      Consensus CDS
      CCDS36701.1
      UniProtKB/TrEMBL
      G8JL31
      Related
      ENSMUSP00000069488.6, ENSMUST00000067821.13
      Conserved Domains (3) summary
      cd00046
      Location:141 → 300
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:125 → 460
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:505 → 619
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      63958793..64048116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517451.4 → XP_006517514.1  DNA excision repair protein ERCC-6-like 2 isoform X4

      Conserved Domains (4) summary
      cd04508
      Location:20 → 70
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      COG0553
      Location:72 → 649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122 → 369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:1101 → 1131
      VIGSSK; Helicase-associated putative binding domain, C-terminal

    2. XM_017315632.2 → XP_017171121.1  DNA excision repair protein ERCC-6-like 2 isoform X1

      Conserved Domains (3) summary
      COG0553
      Location:72 → 649
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122 → 369
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:1074 → 1104
      VIGSSK; Helicase-associated putative binding domain, C-terminal

    3. XM_017315633.2 → XP_017171122.1  DNA excision repair protein ERCC-6-like 2 isoform X2

      Conserved Domains (3) summary
      COG0553
      Location:72 → 609
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18005
      Location:122 → 329
      DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
      pfam14773
      Location:1061 → 1091
      VIGSSK; Helicase-associated putative binding domain, C-terminal

    4. XM_030247457.1 → XP_030103317.1  DNA excision repair protein ERCC-6-like 2 isoform X3

      Conserved Domains (3) summary
      COG0553
      Location:2 → 364
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18793
      Location:219 → 345
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
      pfam14773
      Location:816 → 846
      VIGSSK; Helicase-associated putative binding domain, C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIM3.3 GenPept UniProtKB/Swiss-Prot:Q9JIM3

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