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    Mrpl23 mitochondrial ribosomal protein L23 [ Mus musculus (house mouse) ]

    Gene ID: 19935, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrpl23provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L23provided by MGI
    Primary source
    MGI:MGI:1196612
    See related
    Ensembl:ENSMUSG00000037772 AllianceGenome:MGI:1196612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpl23; L23mrp; Rpl23l
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; liver; and submandibular gland primordium. Orthologous to human MRPL23 (mitochondrial ribosomal protein L23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.3), bladder adult (RPKM 14.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl23 in Genome Data Viewer
    Location:
    7 F5; 7 87.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142086423..142094484)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142532467..142540747)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10483 Neighboring gene lymphocyte specific 1 Neighboring gene proline rich 33 Neighboring gene troponin T3, skeletal, fast Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:149724284-149724471 Neighboring gene H19/Igf2 enhancer region Neighboring gene non-coding transcript 1 Neighboring gene microRNA 675 Neighboring gene H19, imprinted maternally expressed transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7. Purbowasito W, et al. DNA Res, 2004 Dec 31. PMID 15871462
    2. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs. Tomar A, et al. Nature, 2024 Jun. PMID 38839949, Free PMC Article
    3. The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns. Greally JM, et al. Hum Mol Genet, 1998 Jan. PMID 9384608
    4. Sequence of a 42-kb mouse region containing the imprinted H19 locus: identification of a novel muscle-specific transcription unit showing biallelic expression. Ishihara K, et al. Mamm Genome, 1998 Sep. PMID 9716667
    5. Matrix-attachment regions in the mouse chromosome 7F imprinted domain. Greally JM, et al. Mamm Genome, 1997. PMID 9337391

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL23m
    Names
    39S ribosomal protein L23, mitochondrial
    L23 mitochondrial-related protein
    L23mt
    MRP-L23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417208.1 → NP_001404137.1  large ribosomal subunit protein uL23m isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC013548, AL603651
      Related
      ENSMUST00000137345.9

    2. NM_001417209.1 → NP_001404138.1  large ribosomal subunit protein uL23m isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC013548, AL603651

    3. NM_001417210.1 → NP_001404139.1  large ribosomal subunit protein uL23m isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC013548, AL603651

    4. NM_001417211.1 → NP_001404140.1  large ribosomal subunit protein uL23m isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC013548, AL603651
      UniProtKB/TrEMBL
      A0A1B0GQZ1
      Related
      ENSMUSP00000147311.2, ENSMUST00000210803.2

    5. NM_011288.3 → NP_035418.1  large ribosomal subunit protein uL23m isoform 2

      See identical proteins and their annotated locations for NP_035418.1

      Status: VALIDATED

      Source sequence(s)
      AC013548, AL603651
      Consensus CDS
      CCDS22032.1
      UniProtKB/Swiss-Prot
      O35972, Q78E46
      UniProtKB/TrEMBL
      A0A1B0GSZ9
      Related
      ENSMUSP00000039784.7, ENSMUST00000038675.7
      Conserved Domains (1) summary
      pfam00276
      Location:42 → 105
      Ribosomal_L23; Ribosomal protein L23

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      142086423..142094484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508516.5 → XP_006508579.1  large ribosomal subunit protein uL23m isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSZ9
      Related
      ENSMUSP00000148138.2, ENSMUST00000210662.2
      Conserved Domains (1) summary
      pfam00276
      Location:40 → 105
      Ribosomal_L23; Ribosomal protein L23
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35972.1 GenPept UniProtKB/Swiss-Prot:O35972

    Gene LinkOut

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