slc4a2a solute carrier family 4 member 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc4a2aprovided by ZNC
Official Full Name: solute carrier family 4 member 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051101-2
See related: Ensembl:ENSDARG00000028173 AllianceGenome:ZFIN:ZDB-GENE-051101-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: slc4a2
Summary: Enables chloride:bicarbonate antiporter activity. Acts upstream of or within monoatomic anion transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including cardiovascular system; immature eye; midbrain neural rod; optic tectum; and pronephric duct. Human ortholog(s) of this gene implicated in osteopetrosis. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (32391897..32457941, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (32408671..32474705, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Ae2.1 mRNA with nontoxic or minimally toxic levels of N-morpholino oligomers produced no grossly detectable morphological phenotype
Title: Zebrafish ae2.2 encodes a second slc4a2 anion exchanger.

Submit: New GeneRIF Correction

General gene information

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Markers

fc01f03.x1 (e-PCR)
- UniSTS:192045

fc01f03.x1 (e-PCR)
- UniSTS:192046

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic anion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic anion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: anion exchange protein 2a

Names: ae2; ae2.1; anion exchanger 2; solute carrier family 4 (anion exchanger), member 2a; solute carrier family 4, anion exchanger, member 2; solute carrier family 4, anion exchanger, member 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037237.1 → NP_001032314.1 anion exchange protein 2a

See identical proteins and their annotated locations for NP_001032314.1

Status: PROVISIONAL

Source sequence(s)

AY876015

UniProtKB/TrEMBL

Q3KVL6

Related

ENSDARP00000041318.4, ENSDART00000041319.6

Conserved Domains (3) summary

TIGR00834
Location:326 → 1227

ae; anion exchange protein

pfam00955
Location:676 → 1155

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:361 → 625

Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

32391897..32457941 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480959.2 → XP_021336634.1 anion exchange protein 2a isoform X1

UniProtKB/TrEMBL

A0A8M9PZ09

Conserved Domains (1) summary

TIGR00834
Location:345 → 1246

ae; anion exchange protein
XM_021480957.2 → XP_021336632.1 anion exchange protein 2a isoform X1

UniProtKB/TrEMBL

A0A8M9PZ09

Conserved Domains (1) summary

TIGR00834
Location:345 → 1246

ae; anion exchange protein
XM_068224652.1 → XP_068080753.1 anion exchange protein 2a isoform X2
XM_068224655.1 → XP_068080756.1 anion exchange protein 2a isoform X3
XM_005163511.5 → XP_005163568.1 anion exchange protein 2a isoform X1

See identical proteins and their annotated locations for XP_005163568.1

UniProtKB/TrEMBL

A0A8M9PZ09

Conserved Domains (1) summary

TIGR00834
Location:345 → 1246

ae; anion exchange protein