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    pdia3 protein disulfide isomerase family A, member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 378851, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pdia3provided by ZNC
    Official Full Name
    protein disulfide isomerase family A, member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031002-9
    See related
    Ensembl:ENSDARG00000102640 AllianceGenome:ZFIN:ZDB-GENE-031002-9
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Grp58; erp57; sb:cb825
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in cell surface and endoplasmic reticulum. Is expressed in several structures, including axis; hatching gland; hypochord; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pdia3 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (30343015..30357350, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (29900008..29914343, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-281m9.1 Neighboring gene TopBP1-interacting, checkpoint, and replication regulator Neighboring gene carboxylesterase 2b Neighboring gene transfer RNA arginine (anticodon ACG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Calnexin is required for zebrafish posterior lateral line development. Hung IC, et al. Int J Dev Biol, 2013. PMID 23873374
    2. Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants. Kling P, et al. Ecotoxicol Environ Saf, 2008 Oct. PMID 18258299
    3. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Mercer SE, et al. Dev Biol, 2013 Oct 15. PMID 23939298, Free PMC Article
    4. Epitranscriptomic m6A regulation following spinal cord injury. Xing L, et al. J Neurosci Res, 2021 Mar. PMID 33271625
    5. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Chen L, et al. Environ Sci Technol, 2017 Jan 3. PMID 28005350

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase A3
    Names
    glucose regulated protein
    NP_001186666.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199737.1 → NP_001186666.1  protein disulfide-isomerase A3 precursor

      Status: VALIDATED

      Source sequence(s)
      CU694321, EB857174, EH533119, FO907102
      UniProtKB/TrEMBL
      A0A8M1NXI0
      Related
      ENSDARP00000134643.1, ENSDART00000171137.2
      Conserved Domains (5) summary
      cd02995
      Location:367 → 470
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03069
      Location:125 → 230
      PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
      cd03073
      Location:234 → 347
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01130
      Location:18 → 475
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:19 → 116
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      30343015..30357350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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