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    Ndrg3 N-myc downstream regulated gene 3 [ Mus musculus (house mouse) ]

    Gene ID: 29812, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ndrg3provided by MGI
    Official Full Name
    N-myc downstream regulated gene 3provided by MGI
    Primary source
    MGI:MGI:1352499
    See related
    Ensembl:ENSMUSG00000027634 AllianceGenome:MGI:1352499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndr3; 4833415O14Rik
    Summary
    Involved in decidualization. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; forelimb interdigital region mesenchyme; genitourinary system; and thymus primordium. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 162.3), cortex adult (RPKM 113.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndrg3 in Genome Data Viewer
    Location:
    2 H1; 2 77.89 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156769262..156834052, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156927342..156992132, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06191 Neighboring gene STARR-seq mESC enhancer starr_06192 Neighboring gene N-myc downstream regulated gene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06193 Neighboring gene STARR-positive B cell enhancer ABC_E4513 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene DSN1 homolog, MIS12 kinetochore complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers. Sohn HA, et al. Cells, 2022 May 4. PMID 35563842, Free PMC Article
    2. Increased Expression of NDRG3 in Mouse Uterus During Embryo Implantation and in Mouse Endometrial Stromal Cells During In Vitro Decidualization. Yang Q, et al. Reprod Sci, 2018 Aug. PMID 29096585
    3. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners. Xu Y, et al. J Biol Chem, 2023 Jun. PMID 37172727, Free PMC Article
    4. Cloning and expression pattern of the human NDRG3 gene. Zhao W, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406283
    5. Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Okuda T, et al. Biochem Biophys Res Commun, 1999 Dec 9. PMID 10581191

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
      Title: Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
    2. we reported that Ndrg3 gene modulated the lactate induced ERK pathway to facilitate DSB repair in male germ cells, which further regulated meiosis and subsequently fertility in male mouse.
      Title: Ndrg3 gene regulates DSB repair during meiosis through modulation the ERK signal pathway in the male germ cells.
    3. Data suggested that n-myc downstream-regulated gene 3 might play an important role in embryo implantation by regulating decidualization potentially via the estrogen/progesterone/miR-290b-5p pathway.
      Title: Increased Expression of NDRG3 in Mouse Uterus During Embryo Implantation and in Mouse Endometrial Stromal Cells During In Vitro Decidualization.
    4. These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain.
      Title: Differential expression patterns of NDRG family proteins in the central nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in decidualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein NDRG3
    Names
    N-myc downstream regulated 3
    N-myc downstream-regulated gene 3 protein
    protein Ndr3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355391.1 → NP_001342320.1  protein NDRG3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL669932, AL935150
      Consensus CDS
      CCDS50780.1
      UniProtKB/TrEMBL
      Q8VCV2
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    2. NM_001355392.1 → NP_001342321.1  protein NDRG3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AL669932, AL935150
      Consensus CDS
      CCDS16971.1
      UniProtKB/Swiss-Prot
      Q9QYF9
      UniProtKB/TrEMBL
      Q544I1
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    3. NM_001355393.1 → NP_001342322.1  protein NDRG3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' end compared to variant 3. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform (1).
      Source sequence(s)
      AL669932, AL935150
      Conserved Domains (1) summary
      pfam03096
      Location:20 → 305
      Ndr; Ndr family

    4. NM_001355394.1 → NP_001342323.1  protein NDRG3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant (3). The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL669932, AL935150
      Conserved Domains (1) summary
      pfam03096
      Location:1 → 277
      Ndr; Ndr family

    5. NM_013865.2 → NP_038893.1  protein NDRG3 isoform 2

      See identical proteins and their annotated locations for NP_038893.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AK004689, AV032677, BY125191
      Consensus CDS
      CCDS16971.1
      UniProtKB/Swiss-Prot
      Q9QYF9
      UniProtKB/TrEMBL
      Q544I1
      Related
      ENSMUSP00000072144.7, ENSMUST00000072298.13
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    6. NM_180956.1 → NP_851287.1  protein NDRG3 isoform 1

      See identical proteins and their annotated locations for NP_851287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AV032677, BC018504, BY125191
      Consensus CDS
      CCDS50780.1
      UniProtKB/TrEMBL
      Q8VCV2
      Related
      ENSMUSP00000070052.7, ENSMUST00000069600.13
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156769262..156834052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251734.1 → XP_030107594.1  protein NDRG3 isoform X4

      Conserved Domains (1) summary
      pfam03096
      Location:20 → 305
      Ndr; Ndr family

    2. XM_030251736.2 → XP_030107596.1  protein NDRG3 isoform X5

      Conserved Domains (1) summary
      pfam03096
      Location:1 → 277
      Ndr; Ndr family

    3. XM_030251733.1 → XP_030107593.1  protein NDRG3 isoform X2

      Conserved Domains (1) summary
      pfam03096
      Location:20 → 305
      Ndr; Ndr family

    4. XM_011239593.1 → XP_011237895.1  protein NDRG3 isoform X1

      See identical proteins and their annotated locations for XP_011237895.1

      UniProtKB/TrEMBL
      Q8VCV2
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    5. XM_030251732.1 → XP_030107592.1  protein NDRG3 isoform X1

      UniProtKB/TrEMBL
      Q8VCV2
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    6. XM_036162285.1 → XP_036018178.1  protein NDRG3 isoform X3

      UniProtKB/Swiss-Prot
      Q9QYF9
      UniProtKB/TrEMBL
      Q544I1
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    7. XM_036162283.1 → XP_036018176.1  protein NDRG3 isoform X1

      UniProtKB/TrEMBL
      Q8VCV2
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    8. XM_036162284.1 → XP_036018177.1  protein NDRG3 isoform X3

      UniProtKB/Swiss-Prot
      Q9QYF9
      UniProtKB/TrEMBL
      Q544I1
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family

    9. XM_017318968.1 → XP_017174457.1  protein NDRG3 isoform X3

      UniProtKB/Swiss-Prot
      Q9QYF9
      UniProtKB/TrEMBL
      Q544I1
      Conserved Domains (1) summary
      pfam03096
      Location:32 → 317
      Ndr; Ndr family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYF9.1 GenPept UniProtKB/Swiss-Prot:Q9QYF9

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