U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pcdhb22 protocadherin beta 22 [ Mus musculus (house mouse) ]

    Gene ID: 93893, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pcdhb22provided by MGI
    Official Full Name
    protocadherin beta 22provided by MGI
    Primary source
    MGI:MGI:2136760
    See related
    Ensembl:ENSMUSG00000073591 AllianceGenome:MGI:2136760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PcdhbV; Pcdhb15
    Summary
    Predicted to be involved in cell adhesion. Located in photoreceptor connecting cilium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and retina. Orthologous to human PCDHB15 (protocadherin beta 15). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pcdhb22 in Genome Data Viewer
    Location:
    18 B3; 18 19.51 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37651402..37657532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37518353..37521419)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene STARR-seq mESC enhancer starr_44310 Neighboring gene STARR-seq mESC enhancer starr_44311 Neighboring gene protocadherin beta 20 Neighboring gene protocadherin beta 21 Neighboring gene STARR-seq mESC enhancer starr_44313 Neighboring gene STARR-seq mESC enhancer starr_44314 Neighboring gene STARR-positive B cell enhancer ABC_E4245 Neighboring gene solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2 Neighboring gene TATA-box binding protein associated factor 7

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Hirano K, et al. Front Mol Neurosci, 2012. PMID 22969705, Free PMC Article
    2. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
    3. A unique role of cohesin-SA1 in gene regulation and development. Remeseiro S, et al. EMBO J, 2012 May 2. PMID 22415368, Free PMC Article
    4. Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Junghans D, et al. Eur J Neurosci, 2008 Feb. PMID 18279309
    5. Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. Toyoda S, et al. Neuron, 2014 Apr 2. PMID 24698270

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protocadherin beta-15

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053147.4 → NP_444377.3  protocadherin beta-15 precursor

      See identical proteins and their annotated locations for NP_444377.3

      Status: VALIDATED

      Source sequence(s)
      AC020967
      Consensus CDS
      CCDS29187.1
      UniProtKB/TrEMBL
      Q8C8Z3, Q91XZ8
      Related
      ENSMUSP00000141521.2, ENSMUST00000192409.2
      Conserved Domains (3) summary
      cd11304
      Location:245 → 341
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:28 → 110
      Cadherin_2; Cadherin-like
      pfam16492
      Location:686 → 768
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      37651402..37657532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools