Dcun1d4 defective in cullin neddylation 1 domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcun1d4provided by MGI
Official Full Name: defective in cullin neddylation 1 domain containing 4provided by MGI
Primary source: MGI:MGI:2140972
See related: Ensembl:ENSMUSG00000051674 AllianceGenome:MGI:2140972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DCNL4
Summary: Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation and protein neddylation. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Is expressed in early conceptus; genitourinary system; nervous system; and neural retina. Orthologous to human DCUN1D4 (defective in cullin neddylation 1 domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 6.2), cortex adult (RPKM 5.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 38.85 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (73638353..73718137)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (73481010..73560794)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH118288 (e-PCR)
- UniSTS:123181

Dcun1d4 (e-PCR), detects polymorphism
- UniSTS:545924

AI836376 (e-PCR)
- UniSTS:164286

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DCN1-like protein 4

Names: DCN1, defective in cullin neddylation 1, domain containing 4; DCUN1 domain-containing protein 4; defective in cullin neddylation protein 1-like protein 4; squamous cell carcinoma-related oncogene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190733.2 → NP_001177662.1 DCN1-like protein 4 isoform C

See identical proteins and their annotated locations for NP_001177662.1

Status: VALIDATED

Description

Transcript Variant: This variant (C) differs in the 5' UTR, lacks a portion of the 5' coding region and an in-frame exon in the 3' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform A.

Source sequence(s)

AC134551, AC140429

Consensus CDS

CCDS57350.1

UniProtKB/TrEMBL

B7ZMU0

Related

ENSMUSP00000109187.2, ENSMUST00000113558.8

Conserved Domains (1) summary

pfam03556
Location:175 → 251

Cullin_binding; Cullin binding
NM_001190734.2 → NP_001177663.1 DCN1-like protein 4 isoform A

See identical proteins and their annotated locations for NP_001177663.1

Status: VALIDATED

Description

Transcript Variant: This variant (A) encodes the longest isoform (A).

Source sequence(s)

AC134551, AC140429

Consensus CDS

CCDS57349.1

UniProtKB/TrEMBL

Q8C5X2

Related

ENSMUSP00000084427.6, ENSMUST00000087181.12

Conserved Domains (1) summary

pfam03556
Location:189 → 300

Cullin_binding; Cullin binding
NM_001425798.1 → NP_001412727.1 DCN1-like protein 4 isoform D

Status: VALIDATED

Source sequence(s)

AC134551, AC140429
NM_001425799.1 → NP_001412728.1 DCN1-like protein 4 isoform E

Status: VALIDATED

Source sequence(s)

AC134551, AC140429
NM_001425800.1 → NP_001412729.1 DCN1-like protein 4 isoform E

Status: VALIDATED

Source sequence(s)

AC134551, AC140429
NM_178896.6 → NP_849227.1 DCN1-like protein 4 isoform B

See identical proteins and their annotated locations for NP_849227.1

Status: VALIDATED

Description

Transcript Variant: This variant (B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.

Source sequence(s)

AC134551, AC140429

Consensus CDS

CCDS19342.1

UniProtKB/Swiss-Prot

Q2YDW5, Q8CCA0

Related

ENSMUSP00000067616.6, ENSMUST00000063882.12

Conserved Domains (1) summary

pfam03556
Location:175 → 286

Cullin_binding; Cullin binding

RNA

NR_153313.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (D) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC134551, AC140429
NR_189590.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC134551, AC140429
NR_189591.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC134551, AC140429
NR_189592.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC134551, AC140429