4GAO,4GBA,2IS9


Conserved Protein Domain Family
Cullin_binding
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pfam03556: Cullin_binding (this model, PSSM-Id:281545 is obsolete and has been replaced by 460971)
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Cullin binding
This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.
Links
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Statistics
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PSSM-Id: 281545
Aligned: 208 rows
Threshold Bit Score: 82.9626
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4GAO_A        77 KLKALLPRLEQEL-KD-T-Ak-FKDFYQFTFTFAKN---PGq--KG--LDLEMAVAYWKLVL-------SG-------R- 130 human
Q4Q0J0       118 aahdAIVDLNNTI-RS-NeEk-RSKFYQFLYNWCLKgndASd-------RVDSAKELWSCFF-------SA-------S- 172 Leishmania major
Q4CTL1       116 AMRSHVDEIDEVL-HK-DpDq-FRKFYRFIFGWVRSpetTArslGElgMNIATAVELWQMLF-------PE-------Y- 177 Trypanosoma cruzi
Q38A65       115 ALRNHVETLDGAL-RG-DvTk-FRHFYRFIYKWVQSpltMErnmGQvgMSIETAVELWRMLF-------PH-------Y- 176 Trypanosoma brucei
XP_003170487 104 KQAAYADGLRKLL-QDdP-Ny-FRRVYRYTFLLCRM---QGq--RN--VNIELAVEQWQLFF-------TS-------En 159 Arthroderma gyp...
XP_009153669 169 RQSQYVNTIRKRVvTD-P-Ay-FKQVYRNAFKLAKP---EGq--RS--VPMDSAIDFWNMFF-------RQ-------G- 223 Exophiala derma...
XP_002584209 113 KQALHASNLRNRIpTE-P-Al-FRRIYRYAFVLCRL---PGq--RH--LTLEIATEQWRLFF-------TPdnggipwN- 174 Uncinocarpus re...
EPS32865     133 KMAEHANQLRATIpTD-K-Dl-FRRVYCHTFPISRM---AGq--RN--LPYDLAAEQWRLLFtadrggvPW-------S- 194 Penicillium oxa...
XP_007801994 141 aqgEYVKTLRKQLqTD-R-Sy-LKQVYRYTFNLARP---EGq--KN--VPVDAALDFWKMFF-------DA-------D- 195 Endocarpon pusi...
XP_001564670 125 QLRQKLGEWVKDV-RE-S-SgaFLLMYTYMYDYIRG---EEd--RR--MTRTTAINGWDVFF-------GQ-------N- 179 Leishmania braz...

4GAO_A       131 ------F-------KF-----------L-------DLWNTF-LMEHHKRS--------------IPRDTWNLLLDFGN-- 162 human
Q4Q0J0       173 ------P-------VSltveearrkftAyvcfpriNQWLDF-ITMLGEKAtesksgrvaveqsgVSFDTWTQLLLFAr-- 236 Leishmania major
Q4CTL1       178 ------K-------TFlk----------------mNDWITF-CTTKeifh-----------reaISRDLWEQLLEFTSl- 215 Trypanosoma cruzi
Q38A65       177 ------R-------EFkr----------------lDDWITFcMSKKLFPHg------------iISRDLWEQLLEFTFv- 214 Trypanosoma brucei
XP_003170487 160 ggvaweT-------KSvp--------wL-------KWWIEF-IETKHKRp--------------INKDLWEQTEVLMRkt 202 Arthroderma gyp...
XP_009153669 224 ------KggiewntSTtk--------wL-------DLWCEF-YETKNKRp--------------VNKDLWNMVCELVFkt 267 Exophiala derma...
XP_002584209 175 ------T-------NTvp--------wL-------DWWIEF-IENTWKRp--------------VNKDLWEQTEVLMRkt 211 Uncinocarpus re...
EPS32865     195 ------T-------ETtp--------wL-------EWWLEF-LEERGKKa--------------VSKDLWQQLELFMRkt 231 Penicillium oxa...
XP_007801994 196 ------K-------GGiewns-dwtpwL-------DWWLEY-YEAKYKRp--------------ANKDLWNMVGELVNkt 239 Endocarpon pusi...
XP_001564670 180 ------K-------RY-------------------AKWKTW-AVANLTGd--------------VSRDLWRQLGIFLTmd 212 Leishmania braz...

4GAO_A       163 MIa--DDMSNYDEEGA--WPVLIDDFVEYA 188 human
Q4Q0J0       237 ----fDNYDAYDDEDS--WPVTMDDFVVYV 260 Leishmania major
Q4CTL1       216 -----tRYDTYDVNDA--WPSAIDDFVEYF 238 Trypanosoma cruzi
Q38A65       215 -----tDYSKYDVSDA--WPSAMDDFVEYV 237 Trypanosoma brucei
XP_003170487 203 MEd--ESMDWWSSDAA--WPGAIDDFVAFV 228 Arthroderma gypseum CBS 118893
XP_009153669 268 KEpggETLEWWTEDGA--WPMAVDDFVAYV 295 Exophiala dermatitidis NIH/UT8656
XP_002584209 212 LEd--PSLKWWSPDGA--WPGAVDDFVVFA 237 Uncinocarpus reesii 1704
EPS32865     232 REd--ESFGWWSADAA--WPGTLDDFVGWV 257 Penicillium oxalicum 114-2
XP_007801994 240 AEpggENMDWWSEDGA--WPMAVDEFVAFV 267 Endocarpon pusillum Z07020
XP_001564670 213 TDa--TQSSD-DQVLAlsWPSAIADFIEtd 239 Leishmania braziliensis MHOM/BR/75/M2904
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