Car8 carbonic anhydrase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Car8provided by RGD
Official Full Name: carbonic anhydrase 8provided by RGD
Primary source: RGD:1304709
See related: EnsemblRapid:ENSRNOG00000005669 AllianceGenome:RGD:1304709
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ca8
Summary: Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of or within positive regulation of calcium-mediated signaling. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 3. Orthologous to human CA8 (carbonic anhydrase 8). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Brain (RPKM 539.8), Lung (RPKM 299.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (26102767..26199819, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (21302940..21402395, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (21249018..21345810, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Car8 (e-PCR), detects polymorphism
- UniSTS:506778

AA923902 (e-PCR)
- UniSTS:226205

D5Got135 (e-PCR)
- UniSTS:114629

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables hydro-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonic anhydrase-related protein

Names: CA-VIII; CARP; carbonic anhydrase VIII

NP_001009662.1

EC 4.2.1.1

XP_038965331.1

EC 4.2.1.1

XP_038965332.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009662.1 → NP_001009662.1 carbonic anhydrase-related protein

See identical proteins and their annotated locations for NP_001009662.1

Status: PROVISIONAL

Source sequence(s)

BC087586

UniProtKB/Swiss-Prot

Q5PPN4

UniProtKB/TrEMBL

A6JFP9

Related

ENSRNOP00000007802.5, ENSRNOT00000007802.9

Conserved Domains (1) summary

cd03120
Location:35 → 289

alpha_CARP_VIII; Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

26102767..26199819 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109404.2 → XP_038965332.1 carbonic anhydrase-related protein isoform X2

UniProtKB/TrEMBL

A0A0G2K7B9, A0A8I5Y6A0

Related

ENSRNOP00000074141.3, ENSRNOT00000081296.3

Conserved Domains (1) summary

cl00012
Location:20 → 170

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
XM_039109403.2 → XP_038965331.1 carbonic anhydrase-related protein isoform X1

Conserved Domains (1) summary

cl00012
Location:35 → 175

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...