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Conserved domains on  [gi|1958775068|ref|XP_038965332|]
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carbonic anhydrase-related protein isoform X2 [Rattus norvegicus]

Protein Classification

carbonic anhydrase family protein( domain architecture ID 275)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

CATH:  3.10.200.10
Gene Ontology:  GO:0004089|GO:0008270|GO:0006730
PubMed:  10978542|18336305
SCOP:  4002732

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha_CA super family cl00012
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 20-170 6.91e-112

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


The actual alignment was detected with superfamily member cd03120:

Pssm-ID: 469577  Cd Length: 256  Bit Score: 318.34  E-value: 6.91e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  20 KLHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVY 99
Cdd:cd03120   106 ELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVY 185

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03120   186 EGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAELVEGCDGLLGDNFRPTQPLSDRVIRAAF 256
 
Name Accession Description Interval E-value
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 20-170 6.91e-112

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 318.34  E-value: 6.91e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  20 KLHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVY 99
Cdd:cd03120   106 ELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVY 185

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03120   186 EGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAELVEGCDGLLGDNFRPTQPLSDRVIRAAF 256
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
21-170 4.80e-57

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 179.00  E-value: 4.80e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTLfGSIDEAVGKPHGIVIIALFVQIGKEH-VGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDpLLRDYWVY 99
Cdd:pfam00194 109 LHIVHYNSKY-KSFDEAAKHPDGLAVLGVFFEVGDENnPYLQPIVSALDNIKYKGKSVLLPPFDLSDLLPE-DLTSYYTY 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEgcdgiLGDNFRPTQPLSDRVIRAAF 170
Cdd:pfam00194 187 NGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRP-----LVNNFRPTQPLNGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 21-165 9.93e-55

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 173.27  E-value: 9.93e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068   21 LHLIHWNSTlfGSIDEAVGKPHGIVIIALFVQIGKEH-VGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLlRDYWVY 99
Cdd:smart01057 113 LHLVHYNSK--GSFSEAVSKPGGLAVVAVFFKVGAEEnPALQAILDHLPLIKYKGQETELTPFDLSSLLPAST-RHYYTY 189

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958775068  100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVegcdgilgDNFRPTQPLSDRV 165
Cdd:smart01057 190 NGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGNEPLV--------NNARPLQPLNGRV 247
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
21-166 1.51e-29

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 108.43  E-value: 1.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTlfgsideavGKphgIVIIALFVQIGKEHvglKAVTEILQDI-QYKGKSKTIPC-FNPNTLLPDPllRDYWV 98
Cdd:COG3338   130 AHLVHKDAD---------GE---LAVVGVLFEEGAEN---PALAKLWANLpLEAGEEVALDAtIDLNDLLPED--RSYYR 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775068  99 YEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLrthvkgaelvegcdgiLGDNFRPTQPLSDRVI 166
Cdd:COG3338   193 YSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARL----------------YPNNARPVQPLNGRLI 244
PLN02202 PLN02202
carbonate dehydratase
 94-164 7.19e-07

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 47.74  E-value: 7.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068  94 RDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRrlrthvkgaelvEGCDGILGDNFRPTQPLSDR 164
Cdd:PLN02202  202 RKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLR------------SPLDKSFKNNSRPCQPLNGR 260
 
Name Accession Description Interval E-value
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 20-170 6.91e-112

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 318.34  E-value: 6.91e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  20 KLHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVY 99
Cdd:cd03120   106 ELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVY 185

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03120   186 EGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAELVEGCDGLLGDNFRPTQPLSDRVIRAAF 256
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
21-170 4.80e-57

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 179.00  E-value: 4.80e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTLfGSIDEAVGKPHGIVIIALFVQIGKEH-VGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDpLLRDYWVY 99
Cdd:pfam00194 109 LHIVHYNSKY-KSFDEAAKHPDGLAVLGVFFEVGDENnPYLQPIVSALDNIKYKGKSVLLPPFDLSDLLPE-DLTSYYTY 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEgcdgiLGDNFRPTQPLSDRVIRAAF 170
Cdd:pfam00194 187 NGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRP-----LVNNFRPTQPLNGRVVFASF 252
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 21-167 2.24e-56

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 176.70  E-value: 2.24e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTLFGSidEAVGKPHGIVIIALFVQIG-KEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLlRDYWVY 99
Cdd:cd00326    92 LHLVHYNSDYYSS--EAAKKPGGLAVLGVFFEVGeKENPFLKKILDALPKIKYKGKETTLPPFDLSDLLPSSL-RDYYTY 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAelvegcdgiLGDNFRPTQPLSDRVIR 167
Cdd:cd00326   169 EGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDREGKP---------LVNNYRPVQPLNGRVVY 227
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 21-165 9.93e-55

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 173.27  E-value: 9.93e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068   21 LHLIHWNSTlfGSIDEAVGKPHGIVIIALFVQIGKEH-VGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLlRDYWVY 99
Cdd:smart01057 113 LHLVHYNSK--GSFSEAVSKPGGLAVVAVFFKVGAEEnPALQAILDHLPLIKYKGQETELTPFDLSSLLPAST-RHYYTY 189

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958775068  100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVegcdgilgDNFRPTQPLSDRV 165
Cdd:smart01057 190 NGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGNEPLV--------NNARPLQPLNGRV 247
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
 21-170 2.74e-46

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 151.82  E-value: 2.74e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTlFGSIDEAVGKPHGIVIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPllRDYWVYE 100
Cdd:cd03119   118 LHLVHWNSK-YGSFGEAAKQPDGLAVVGVFLKVGEANPELQKVLDALDSIKTKGKQAPFTNFDPSCLLPAS--LDYWTYP 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068 101 GSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVegcdgILGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03119   195 GSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNAEGEPPC-----PMVDNWRPPQPLKGRKVRASF 259
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 20-170 5.25e-46

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 150.37  E-value: 5.25e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  20 KLHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLlrDYWVY 99
Cdd:cd03149    93 ELHLVHWNAKKYKSFGEAAAAPDGLAVLGVFLETGDEHPGLNRLTDALYMVRFKGTKAQFLDFNPKCLLPKSL--DYWTY 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEgcdgiLGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03149   171 PGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDQRNH-----MVNNFRPPQPLKGRTVRASF 236
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 20-170 2.60e-40

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 136.13  E-value: 2.60e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  20 KLHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDplLRDYWVY 99
Cdd:cd03118    93 ELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVDALPEVRHKDTVVEFNPFDPSCLLPA--CRDYWTY 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAElvegcDGILGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03118   171 PGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEE-----EKVMVNNFRPLQPLMNRKVRSSF 236
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
 21-170 1.76e-36

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 126.27  E-value: 1.76e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIG-KEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRdYWVY 99
Cdd:cd03123   107 LHIVHYNSDKYSSFDEAADKPDGLAVLAILIEVGyPENTYYEKIISHLHEIKYKGQETTVPGFNVRELLPEDLSH-YYRY 185

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEefrRLRTHVKGAElvegcDGILGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03123   186 EGSLTTPPCYESVLWTVFRDPVTLSKEQLE---TLENTLMDTH-----NKTLQNNYRATQPLNGRVVEASF 248
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 21-166 4.48e-33

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 117.37  E-value: 4.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTlFGSIDEAVGKPHGIVIIALFVQIGKEH-VGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVY 99
Cdd:cd03117    93 LHIVHIKES-YNSLLEALKDSDGLAVLGFFIEEGEEEnTNFDPLISALSNIPQKGGSTNLTPFSLRSLLPSVLLTKYYRY 171

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRL--RTHVKGAELVegcdgilgDNFRPTQPLSDRVI 166
Cdd:cd03117   172 NGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVlfFDTDNGQPMV--------NNFRPVQPLNGRVV 232
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 21-166 5.65e-33

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 117.46  E-value: 5.65e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNsTLFGSIDEAVGKPHGIVIIALFVQIGKEH-VGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPdPLLRDYWVY 99
Cdd:cd03122   110 MQILHRN-TDFFDSFEAIKSPGGVLALAYLFELSHEDnPFLDPIIEGLRNVSRPGKEVELPPFPLSDLLP-PFTDKYYSY 187

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958775068 100 EGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRThvKGAELVEGCDGILGdNFRPTQPLSDRVI 166
Cdd:cd03122   188 EGSLTTPPCSETVEWIVFREPVPISSRQLEAFRELLT--RRQDGVMSGDYLPN-NGRPQQPLGSRTV 251
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 12-170 2.61e-32

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 115.70  E-value: 2.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  12 ISSLWNFEKLHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDP 91
Cdd:cd03126    97 ISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGPFNPSYEKIFSHLHEVKYKDQKVSVPGFNVQELLPKR 176

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775068  92 lLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEefrRLRTHVKGAELVEGCDgiLGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03126   177 -LDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLL---ALETALYSTEEDESRE--MVNNYRQVQPFNERLVFASF 249
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
 21-167 1.24e-30

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 111.35  E-value: 1.24e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTLFGSIDEAVGKPHGIVIIALFVQIGK----EHVGLKAVTEILQdIQYKGKSKTIPCFNPNTLLPDplLRDY 96
Cdd:cd03121   110 VQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGEtsnpELRRLTNRDTITS-IRYKGDAYFLQDLSIELLLPE--TDHY 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068  97 WVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEgcdgiLGDNFRPTQPLSDRVIR 167
Cdd:cd03121   187 ITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAP-----MSPNFRPVQPLNNRPVR 252
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
21-166 1.51e-29

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 108.43  E-value: 1.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  21 LHLIHWNSTlfgsideavGKphgIVIIALFVQIGKEHvglKAVTEILQDI-QYKGKSKTIPC-FNPNTLLPDPllRDYWV 98
Cdd:COG3338   130 AHLVHKDAD---------GE---LAVVGVLFEEGAEN---PALAKLWANLpLEAGEEVALDAtIDLNDLLPED--RSYYR 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775068  99 YEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLrthvkgaelvegcdgiLGDNFRPTQPLSDRVI 166
Cdd:COG3338   193 YSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARL----------------YPNNARPVQPLNGRLI 244
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 20-170 2.37e-28

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 105.42  E-value: 2.37e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  20 KLHLIHWNSTlFGSIDEAVGKPHGIVIIALFVQIG-KEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRdYWV 98
Cdd:cd03150   105 EIHVVHLSTA-FANLDEALGRPGGLAVLAAFLAEGlHENSAYEQLLSRLSEISEEESETVVPGLDVSALLPSDLSR-YFR 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958775068  99 YEGSLTIPPCSEGVTWILFRYPLTISQLQIEEfrrLRTHVKGAElvegcDGILGDNFRPTQPLSDRVIRAAF 170
Cdd:cd03150   183 YEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHT---LSDSLWGPH-----DSRLQLNFRATQPLNGRKIEASF 246
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 20-171 1.19e-26

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 101.02  E-value: 1.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  20 KLHLIHWNSTlFGSIDEAVGKPHGIVIIALFVQIGK--EHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLlRDYW 97
Cdd:cd03125   106 ELHIVHYNSK-YKSYEEAKDKPDGLAVLAFLYKVGHyaENTYYSDFISKLAKIKYAGQTTTLTSLDVRDMLPENL-HHYY 183

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958775068  98 VYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRlrthvkgaELVEGCDGILGDNFRPTQPLSDRVIRAAFQ 171
Cdd:cd03125   184 TYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLEN--------TLMDHHNKTIRNDYRRTQPLNHRVVEANFL 249
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 44-166 1.21e-26

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 100.04  E-value: 1.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068  44 IVIIALFVQIGKEHVGLKAvteILQDI--QYKGKSKTIPCFNPNTLLPDplLRDYWVYEGSLTIPPCSEGVTWILFRYPL 121
Cdd:cd03124   110 LAVVAVLFEEGKENPFLKK---ILDNMpkKEGTEVNLPAILDPNELLPE--SRSYYRYEGSLTTPPCSEGVRWIVLKQPI 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958775068 122 TISQLQIEEFRRLRTHvkgaelvegcdgilgDNFRPTQPLSDRVI 166
Cdd:cd03124   185 TISKEQLAKFRAAVYP---------------NNARPVQPLNGREV 214
PLN02202 PLN02202
carbonate dehydratase
 94-164 7.19e-07

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 47.74  E-value: 7.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775068  94 RDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRrlrthvkgaelvEGCDGILGDNFRPTQPLSDR 164
Cdd:PLN02202  202 RKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLR------------SPLDKSFKNNSRPCQPLNGR 260
PLN02179 PLN02179
carbonic anhydrase
 6-114 1.34e-04

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 40.73  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775068   6 PAPHSPISSLWNFEkLHLIHwnstlfgsiDEAVGKphgIVIIALFVQIGKEHvglKAVTEILQDIQYKGKSKTipcfnpN 85
Cdd:PLN02179  130 PSEHTINGTSYDLE-LHMVH---------TSASGK---TAVVGVLYKLGEPD---EFLTKLLNGIKGVGKKEI------N 187

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958775068  86 TLLPDPL-----LRDYWVYEGSLTIPPCSEGVTW 114
Cdd:PLN02179  188 LGIVDPRdirfeTNNFYRYIGSLTIPPCTEGVIW 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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