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    AMOTL2 angiomotin like 2 [ Homo sapiens (human) ]

    Gene ID: 51421, updated on 29-Oct-2024

    Summary

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    Official Symbol
    AMOTL2provided by HGNC
    Official Full Name
    angiomotin like 2provided by HGNC
    Primary source
    HGNC:HGNC:17812
    See related
    Ensembl:ENSG00000114019 MIM:614658; AllianceGenome:HGNC:17812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LCCP
    Summary
    Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in fat (RPKM 33.7), placenta (RPKM 20.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AMOTL2 in Genome Data Viewer
    Location:
    3q22.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (134355345..134375417, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (137100500..137120572, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134074187..134094259, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374118 Neighboring gene Sharpr-MPRA regulatory regions 684 and 10996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134049669-134050234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134052314-134053166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134053167-134054017 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:134059546-134060745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134078332-134078892 Neighboring gene ribosomal protein L39 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 9661 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134092549-134093348 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134093349-134094148 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:134094149-134094946 Neighboring gene microRNA 6827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134100919-134101418 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:134124670-134125376 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134126084-134126789 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:134145749-134146948 Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene microRNA 4788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells. Wang H, et al. IUBMB Life, 2024 Oct. PMID 38717123
    2. Angiomotin-like 2 interacts with and negatively regulates AKT. Han H, et al. Oncogene, 2017 Aug 10. PMID 28368415
    3. AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. Mojallal M, et al. Nat Commun, 2014 Aug 1. PMID 25080976
    4. AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells. Lucci V, et al. Gene, 2013 Oct 25. PMID 23911299
    5. AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization. Chen X, et al. Oncol Rep, 2021 Jul. PMID 34036399, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells.
      Title: The cellular localization and oncogenic or tumor suppressive effects of angiomiotin-like protein 2 in tumor and normal cells.
    2. The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
      Title: The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
    3. AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.
      Title: AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.
    4. AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
      Title: AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
    5. AMOTL2knockdown promotes the proliferation, migration and invasion of glioma by regulating betacatenin nuclear localization.
      Title: AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization.
    6. AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
      Title: AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
    7. the localization of IQGAP1, AmotL2, and FKBP51 in malignant cells and tumor microenvironment of human GB tumors
      Title: IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.
    8. these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention
      Title: Angiomotin-like 2 interacts with and negatively regulates AKT.
    9. study reports for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP inhibition
      Title: Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.
    10. mTORC2-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP signaling.
      Title: Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Knockdown of Angiomotin (AMOT) by siRNA inhibits HIV-1 release and infectivity, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed
    gag Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of cell polarity involved in ameboidal cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    angiomotin-like protein 2
    Names
    Leman coiled-coil protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278683.1 → NP_001265612.1  angiomotin-like protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein.
      Source sequence(s)
      AF175966, AI214560, AK299270, AW294642, BC011454
      Consensus CDS
      CCDS63784.1
      UniProtKB/Swiss-Prot
      Q9Y2J4
      Related
      ENSP00000424765.1, ENST00000514516.5
      Conserved Domains (2) summary
      pfam06156
      Location:370 → 422
      DUF972; Protein of unknown function (DUF972)
      pfam12240
      Location:540 → 741
      Angiomotin_C; Angiomotin C terminal

    2. NM_001278685.2 → NP_001265614.1  angiomotin-like protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus and lacks two internal amino acids compared to isoform 1.
      Source sequence(s)
      AF175966, AI214560, AK223598, AK299270, AW294642, BC011454, DA330301
      Consensus CDS
      CCDS63783.1
      UniProtKB/Swiss-Prot
      Q9Y2J4
      Related
      ENSP00000425475.1, ENST00000513145.1
      Conserved Domains (2) summary
      pfam06156
      Location:312 → 364
      DUF972; Protein of unknown function (DUF972)
      pfam12240
      Location:482 → 681
      Angiomotin_C; Angiomotin C terminal

    3. NM_001363943.2 → NP_001350872.1  angiomotin-like protein 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC010207
      Consensus CDS
      CCDS87138.1
      UniProtKB/Swiss-Prot
      A8K6F1, B7Z5Q1, E9PHW3, Q53EP1, Q96F99, Q9UKB4, Q9Y2J4
      Related
      ENSP00000409999.2, ENST00000422605.6
      Conserved Domains (2) summary
      COG1196
      Location:298 → 581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12240
      Location:482 → 684
      Angiomotin_C; Angiomotin C terminal

    4. NM_016201.4 → NP_057285.3  angiomotin-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_057285.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus and contains an additional internal amino acid compared to isoform 1.
      Source sequence(s)
      AF175966, AI214560, AK291616, AW294642, BC011454, DA330301
      Consensus CDS
      CCDS33860.1
      UniProtKB/Swiss-Prot
      Q9Y2J4
      Related
      ENSP00000249883.5, ENST00000249883.10
      Conserved Domains (2) summary
      pfam06156
      Location:312 → 364
      DUF972; Protein of unknown function (DUF972)
      pfam12240
      Location:482 → 683
      Angiomotin_C; Angiomotin C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      134355345..134375417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      137100500..137120572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2J4.3 GenPept UniProtKB/Swiss-Prot:Q9Y2J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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