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Conserved domains on  [gi|522838240|ref|NP_001265612|]
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angiomotin-like protein 2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Angiomotin_C pfam12240
Angiomotin C terminal; This domain family is found in eukaryotes, and is typically between 197 ...
 540-745 7.00e-95

Angiomotin C terminal; This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin. The C terminal region of angiomotin appears to be involved in directing the protein chemotactically.


:

Pssm-ID: 463503 [Multi-domain]  Cd Length: 200  Bit Score: 295.14  E-value: 7.00e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  540 YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGsggspELSALRLSEQLREKEEQILA 619
Cdd:pfam12240   1 YVEKVERLQQALAQLQAACEKREQLELRLRTRLEQELKSLRAQQRQGGSQGSGPS-----EYSAPALMELLREKEERILA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  620 LEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDA 699
Cdd:pfam12240  76 LEADMTKWEQKYLEESTMRQFAMDAAATAAAQRDTTIINHSPRHSYDSSFNEELLLANRRCQEMENRIKNLHAQILEKDA 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 522838240  700 VIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFaAAAAGTQGWQGLSS 745
Cdd:pfam12240 156 MIKVLQQRSRKDPGKTDQQSLRPARSVPSIS-AAATGLHSRQTSLS 200
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 370-639 1.31e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 74.97  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 370 AQMEAVLRENARLQRDNERLQRELES-SAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKtmrnkmdsEMRRLQDF 448
Cdd:COG1196  239 AELEELEAELEELEAELEELEAELAElEAELEELRLELEELELELEEAQAEEYELLAELARLEQ--------DIARLEER 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 449 NRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 528
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 529 RAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSE 608
Cdd:COG1196  391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470

                        250       260       270
                 ....*....|....*....|....*....|.
gi 522838240 609 QLREKEEQILALEADMTKWEQKYLEERAMRQ 639
Cdd:COG1196  471 EAALLEAALAELLEELAEAAARLLLLLEAEA 501
 
Name Accession Description Interval E-value
Angiomotin_C pfam12240
Angiomotin C terminal; This domain family is found in eukaryotes, and is typically between 197 ...
 540-745 7.00e-95

Angiomotin C terminal; This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin. The C terminal region of angiomotin appears to be involved in directing the protein chemotactically.


Pssm-ID: 463503 [Multi-domain]  Cd Length: 200  Bit Score: 295.14  E-value: 7.00e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  540 YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGsggspELSALRLSEQLREKEEQILA 619
Cdd:pfam12240   1 YVEKVERLQQALAQLQAACEKREQLELRLRTRLEQELKSLRAQQRQGGSQGSGPS-----EYSAPALMELLREKEERILA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  620 LEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDA 699
Cdd:pfam12240  76 LEADMTKWEQKYLEESTMRQFAMDAAATAAAQRDTTIINHSPRHSYDSSFNEELLLANRRCQEMENRIKNLHAQILEKDA 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 522838240  700 VIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFaAAAAGTQGWQGLSS 745
Cdd:pfam12240 156 MIKVLQQRSRKDPGKTDQQSLRPARSVPSIS-AAATGLHSRQTSLS 200
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 370-639 1.31e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 74.97  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 370 AQMEAVLRENARLQRDNERLQRELES-SAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKtmrnkmdsEMRRLQDF 448
Cdd:COG1196  239 AELEELEAELEELEAELEELEAELAElEAELEELRLELEELELELEEAQAEEYELLAELARLEQ--------DIARLEER 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 449 NRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 528
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 529 RAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSE 608
Cdd:COG1196  391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470

                        250       260       270
                 ....*....|....*....|....*....|.
gi 522838240 609 QLREKEEQILALEADMTKWEQKYLEERAMRQ 639
Cdd:COG1196  471 EAALLEAALAELLEELAEAAARLLLLLEAEA 501
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 367-762 3.06e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.27  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 367 AHLAQMEAVLRE-NARLqrdnERLQRElessAEKAGRIEKLESEIQ---------RLSEAHESLTRASSKREALEKTmRN 436
Cdd:COG1196  186 ENLERLEDILGElERQL----EPLERQ----AEKAERYRELKEELKeleaellllKLRELEAELEELEAELEELEAE-LE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 437 KMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDmVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELL 516
Cdd:COG1196  257 ELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE-LARLEQDIARLEERRRELEERLEELEEELAELEEELEEL 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 517 EQALGNAQGRAARAEEELRKKQayvekvERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 596
Cdd:COG1196  336 EEELEELEEELEEAEEELEEAE------AELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE 409

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 597 GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLtg 676
Cdd:COG1196  410 EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELA-- 487

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 677 ghRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPAR 756
Cdd:COG1196  488 --EAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEY 565


                 ....*.
gi 522838240 757 LTTDRA 762
Cdd:COG1196  566 LKAAKA 571
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 370-639 3.42e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.85  E-value: 3.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   370 AQMEAVLRENARLQRDNERLQRELESSAEK----AGRIEKLESEIQRLSEAHESLTRASSK-REALEKTMRN-------K 437
Cdd:TIGR02169  716 RKIGEIEKEIEQLEQEEEKLKERLEELEEDlsslEQEIENVKSELKELEARIEELEEDLHKlEEALNDLEARlshsripE 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   438 MDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAgSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLE 517
Cdd:TIGR02169  796 IQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEY-LEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELE 874

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   518 QALGNAQGRAARAEEELRKKQAyveKVERLQQALGQLQAACEKREQLELRLRTRLEqelkALRAQQRQAGAPGGSSGSGG 597
Cdd:TIGR02169  875 AALRDLESRLGDLKKERDELEA---QLRELERKIEELEAQIEKKRKRLSELKAKLE----ALEEELSEIEDPKGEDEEIP 947

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 522838240   598 SPELSALRLSEQLREKEEQILALEADMTKWEQKYlEERAMRQ 639
Cdd:TIGR02169  948 EEELSLEDVQAELQRVEEEIRALEPVNMLAIQEY-EEVLKRL 988
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 380-707 6.45e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 6.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   380 ARLQRDNERLQRELEssaekagrIEKLESEIQRLSEAHESLTRAsskrealektmRNKMDSEMRRLQDFNRDLRERLESA 459
Cdd:TIGR02168  664 GSAKTNSSILERRRE--------IEELEEKIEELEEKIAELEKA-----------LAELRKELEELEEELEQLRKELEEL 724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   460 NRRLASKTQEAQAGSQdmvakllaqsyeqqqEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 539
Cdd:TIGR02168  725 SRQISALRKDLARLEA---------------EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA 789

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   540 yveKVERLQQALGQLqaacekREQLElrlrtRLEQELKALR-AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQIL 618
Cdd:TIGR02168  790 ---QIEQLKEELKAL------REALD-----ELRAELTLLNeEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIE 855

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   619 ALEADMTkwEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHspqpsPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKD 698
Cdd:TIGR02168  856 SLAAEIE--ELEELIEELESELEALLNERASLEEALALLRS-----ELEELSEELRELESKRSELRRELEELREKLAQLE 928


                   ....*....
gi 522838240   699 AVIKVLQQR 707
Cdd:TIGR02168  929 LRLEGLEVR 937
PTZ00121 PTZ00121
MAEBL; Provisional
 373-638 1.22e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  373 EAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASS---KREALEKTMRNKMDSEMRRLQDfN 449
Cdd:PTZ00121 1455 EAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEakkKADEAKKAEEAKKADEAKKAEE-A 1533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  450 RDLRERLESANRRLASKTQEAQAgsqdmVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQ---RRRAELLEQALGNAQGR 526
Cdd:PTZ00121 1534 KKADEAKKAEEKKKADELKKAEE-----LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaeeARIEEVMKLYEEEKKMK 1608

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  527 A--ARAEEELRKKQAYVEKVERLQQALGQLQAACE----KREQL---ELRLRTRLEQELKALRAQQRQAGAPGGSSGSGG 597
Cdd:PTZ00121 1609 AeeAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAeekkKAEELkkaEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEK 1688

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 522838240  598 SPELSALRLSEQLREKEEQILALEADMTKWEQ--KYLEERAMR 638
Cdd:PTZ00121 1689 KAAEALKKEAEEAKKAEELKKKEAEEKKKAEElkKAEEENKIK 1731
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 370-585 2.50e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 48.30  E-value: 2.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   370 AQMEAVLRENARLQRDNERLQR----ELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRR- 444
Cdd:pfam12128  312 AADAAVAKDRSELEALEDQHGAfldaDIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRd 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   445 LQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLlaqsyeqqqeqekleremallRGAIEDQRRRAELLEQALGNAQ 524
Cdd:pfam12128  392 IAGIKDKLAKIREARDRQLAVAEDDLQALESELREQL---------------------EAGKLEFNEEEYRLKSRLGELK 450

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 522838240   525 GRAARA---EEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKAL-----RAQQRQ 585
Cdd:pfam12128  451 LRLNQAtatPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALrqasrRLEERQ 519
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 369-470 9.59e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 40.26  E-value: 9.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   369 LAQMEAVLRENARLQRDNERLQRELESSAEKagrIEKLESEIQRlseahESLTRASSKREALEKTMrNKMDSEMRRL-QD 447
Cdd:smart00935  10 LQESPAGKAAQKQLEKEFKKRQAELEKLEKE---LQKLKEKLQK-----DAATLSEAAREKKEKEL-QKKVQEFQRKqQK 80

                           90       100
                   ....*....|....*....|...
gi 522838240   448 FNRDLRERLESANRRLASKTQEA 470
Cdd:smart00935  81 LQQDLQKRQQEELQKILDKINKA 103
 
Name Accession Description Interval E-value
Angiomotin_C pfam12240
Angiomotin C terminal; This domain family is found in eukaryotes, and is typically between 197 ...
 540-745 7.00e-95

Angiomotin C terminal; This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin. The C terminal region of angiomotin appears to be involved in directing the protein chemotactically.


Pssm-ID: 463503 [Multi-domain]  Cd Length: 200  Bit Score: 295.14  E-value: 7.00e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  540 YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGsggspELSALRLSEQLREKEEQILA 619
Cdd:pfam12240   1 YVEKVERLQQALAQLQAACEKREQLELRLRTRLEQELKSLRAQQRQGGSQGSGPS-----EYSAPALMELLREKEERILA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  620 LEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDA 699
Cdd:pfam12240  76 LEADMTKWEQKYLEESTMRQFAMDAAATAAAQRDTTIINHSPRHSYDSSFNEELLLANRRCQEMENRIKNLHAQILEKDA 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 522838240  700 VIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFaAAAAGTQGWQGLSS 745
Cdd:pfam12240 156 MIKVLQQRSRKDPGKTDQQSLRPARSVPSIS-AAATGLHSRQTSLS 200
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 370-639 1.31e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 74.97  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 370 AQMEAVLRENARLQRDNERLQRELES-SAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKtmrnkmdsEMRRLQDF 448
Cdd:COG1196  239 AELEELEAELEELEAELEELEAELAElEAELEELRLELEELELELEEAQAEEYELLAELARLEQ--------DIARLEER 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 449 NRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 528
Cdd:COG1196  311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 529 RAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSE 608
Cdd:COG1196  391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470

                        250       260       270
                 ....*....|....*....|....*....|.
gi 522838240 609 QLREKEEQILALEADMTKWEQKYLEERAMRQ 639
Cdd:COG1196  471 EAALLEAALAELLEELAEAAARLLLLLEAEA 501
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 367-616 3.22e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 70.35  E-value: 3.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 367 AHLAQMEAVLREN-ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRL 445
Cdd:COG1196  260 AELAELEAELEELrLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 446 QDfnrdLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELlEQALGNAQG 525
Cdd:COG1196  340 EE----LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEEL-EEAEEALLE 414

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 526 RAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR 605
Cdd:COG1196  415 RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLL 494

                        250
                 ....*....|.
gi 522838240 606 LSEQLREKEEQ 616
Cdd:COG1196  495 LLLEAEADYEG 505
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 367-762 3.06e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.27  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 367 AHLAQMEAVLRE-NARLqrdnERLQRElessAEKAGRIEKLESEIQ---------RLSEAHESLTRASSKREALEKTmRN 436
Cdd:COG1196  186 ENLERLEDILGElERQL----EPLERQ----AEKAERYRELKEELKeleaellllKLRELEAELEELEAELEELEAE-LE 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 437 KMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDmVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELL 516
Cdd:COG1196  257 ELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE-LARLEQDIARLEERRRELEERLEELEEELAELEEELEEL 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 517 EQALGNAQGRAARAEEELRKKQayvekvERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 596
Cdd:COG1196  336 EEELEELEEELEEAEEELEEAE------AELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE 409

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 597 GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLtg 676
Cdd:COG1196  410 EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELA-- 487

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 677 ghRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPAR 756
Cdd:COG1196  488 --EAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEY 565


                 ....*.
gi 522838240 757 LTTDRA 762
Cdd:COG1196  566 LKAAKA 571
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 370-639 3.42e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.85  E-value: 3.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   370 AQMEAVLRENARLQRDNERLQRELESSAEK----AGRIEKLESEIQRLSEAHESLTRASSK-REALEKTMRN-------K 437
Cdd:TIGR02169  716 RKIGEIEKEIEQLEQEEEKLKERLEELEEDlsslEQEIENVKSELKELEARIEELEEDLHKlEEALNDLEARlshsripE 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   438 MDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAgSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLE 517
Cdd:TIGR02169  796 IQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEY-LEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELE 874

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   518 QALGNAQGRAARAEEELRKKQAyveKVERLQQALGQLQAACEKREQLELRLRTRLEqelkALRAQQRQAGAPGGSSGSGG 597
Cdd:TIGR02169  875 AALRDLESRLGDLKKERDELEA---QLRELERKIEELEAQIEKKRKRLSELKAKLE----ALEEELSEIEDPKGEDEEIP 947

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 522838240   598 SPELSALRLSEQLREKEEQILALEADMTKWEQKYlEERAMRQ 639
Cdd:TIGR02169  948 EEELSLEDVQAELQRVEEEIRALEPVNMLAIQEY-EEVLKRL 988
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 370-630 9.20e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.30  E-value: 9.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   370 AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQR-LSEAHESLTRASSKREALEKTMRNkMDSEMRRLQDF 448
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRqISALRKDLARLEAEVEQLEERIAQ-LSKELTELEAE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   449 NRDLRERLESANRRLASKTQEAQAGSQDmVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 528
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQ-IEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   529 RAEEELRKKQayvEKVERLQQALGQLQAACEK-REQLE--LRLRTRLEQELKALRAQQRQagapggSSGSGGSPELSALR 605
Cdd:TIGR02168  842 DLEEQIEELS---EDIESLAAEIEELEELIEElESELEalLNERASLEEALALLRSELEE------LSEELRELESKRSE 912

                          250       260
                   ....*....|....*....|....*
gi 522838240   606 LSEQLREKEEQILALEADMTKWEQK 630
Cdd:TIGR02168  913 LRRELEELREKLAQLELRLEGLEVR 937
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
402-622 3.11e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.62  E-value: 3.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  402 RIEKLESEIQRLSEAHESLTRASSKREALektmrnkmdsemrrlqdfnrdlrERLESANRRLASKTQEAQAgSQDMVAKL 481
Cdd:COG4913   226 AADALVEHFDDLERAHEALEDAREQIELL-----------------------EPIRELAERYAAARERLAE-LEYLRAAL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  482 laqsyeqqqEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK-KQAY----VEKVERLQQALGQLQA 556
Cdd:COG4913   282 ---------RLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDElEAQIrgngGDRLEQLEREIERLER 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  557 ACEKREQLELRLRTRL----------EQELKALRAQQRQAGAPGGSSGSGGSPELSALR-----LSEQLREKEEQILALE 621
Cdd:COG4913   353 ELEERERRRARLEALLaalglplpasAEEFAALRAEAAALLEALEEELEALEEALAEAEaalrdLRRELRELEAEIASLE 432


                  .
gi 522838240  622 A 622
Cdd:COG4913   433 R 433
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 378-633 4.35e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.00  E-value: 4.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   378 ENARLQRDNERLQRELESSAEKAGRIEKLESEI-QRLSEAHESLTRASSKREALEKTmRNKMDSEMRRLQDFNRDLRERL 456
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELsQELSDASRKIGEIEKEIEQLEQE-EEKLKERLEELEEDLSSLEQEI 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   457 ESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAEL----LEQALGNAQGRAARAEE 532
Cdd:TIGR02169  754 ENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEArlreIEQKLNRLTLEKEYLEK 833

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   533 ELRKKQAYVEKVERlqqalgQLQAACEKREQLELRLRtRLEQELKALRAQQRQagapggssgsggspelsalrLSEQLRE 612
Cdd:TIGR02169  834 EIQELQEQRIDLKE------QIKSIEKEIENLNGKKE-ELEEELEELEAALRD--------------------LESRLGD 886

                          250       260
                   ....*....|....*....|.
gi 522838240   613 KEEQILALEADMTKWEQKYLE 633
Cdd:TIGR02169  887 LKKERDELEAQLRELERKIEE 907
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 365-585 1.47e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 365 GSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAhesLTRASSKREALEKTMrNKMDSEMRR 444
Cdd:COG4942   12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERR---IAALARRIRALEQEL-AALEAELAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 445 LQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAqsyeQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 524
Cdd:COG4942   88 LEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLL----SPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELA 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 522838240 525 GRAARAEEELRKKQAYVEKVERLQQALGQLQAaceKREQLELRLRTRLEQELKALRAQQRQ 585
Cdd:COG4942  164 ALRAELEAERAELEALLAELEEERAALEALKA---ERQKLLARLEKELAELAAELAELQQE 221
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 367-631 3.00e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 51.22  E-value: 3.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   367 AHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI----------------QRLSEAHESLTRASSKREAL 430
Cdd:TIGR02169  234 ALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELnkkikdlgeeeqlrvkEKIGELEAEIASLERSIAEK 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   431 EKTMRN------KMDSEMRRLQDFNRDLRERLESANRRLASKT---QEAQAGSQDMVAKL----------LAQSYEQQQE 491
Cdd:TIGR02169  314 ERELEDaeerlaKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyAELKEELEDLRAELeevdkefaetRDELKDYREK 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   492 QEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVE----KVERLQQALGQLQAACEKREQLELR 567
Cdd:TIGR02169  394 LEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEdkalEIKKQEWKLEQLAADLSKYEQELYD 473

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838240   568 LRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKY 631
Cdd:TIGR02169  474 LKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERY 537
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
402-585 6.38e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 6.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  402 RIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKmDSEMRRLQDFNRDLRErLESANRRLASKTQEAQA--GSQDMVA 479
Cdd:COG4913   611 KLAALEAELAELEEELAEAEERLEALEAELDALQER-REALQRLAEYSWDEID-VASAEREIAELEAELERldASSDDLA 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  480 KLlaqsyeqqqeqeklEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQAlgQLQAACE 559
Cdd:COG4913   689 AL--------------EEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARL--ELRALLE 752

                         170       180       190
                  ....*....|....*....|....*....|..
gi 522838240  560 KR------EQLELRLRTRLEQELKALRAQQRQ 585
Cdd:COG4913   753 ERfaaalgDAVERELRENLEERIDALRARLNR 784
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 380-707 6.45e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 6.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   380 ARLQRDNERLQRELEssaekagrIEKLESEIQRLSEAHESLTRAsskrealektmRNKMDSEMRRLQDFNRDLRERLESA 459
Cdd:TIGR02168  664 GSAKTNSSILERRRE--------IEELEEKIEELEEKIAELEKA-----------LAELRKELEELEEELEQLRKELEEL 724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   460 NRRLASKTQEAQAGSQdmvakllaqsyeqqqEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 539
Cdd:TIGR02168  725 SRQISALRKDLARLEA---------------EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA 789

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   540 yveKVERLQQALGQLqaacekREQLElrlrtRLEQELKALR-AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQIL 618
Cdd:TIGR02168  790 ---QIEQLKEELKAL------REALD-----ELRAELTLLNeEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIE 855

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   619 ALEADMTkwEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHspqpsPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKD 698
Cdd:TIGR02168  856 SLAAEIE--ELEELIEELESELEALLNERASLEEALALLRS-----ELEELSEELRELESKRSELRRELEELREKLAQLE 928


                   ....*....
gi 522838240   699 AVIKVLQQR 707
Cdd:TIGR02168  929 LRLEGLEVR 937
PTZ00121 PTZ00121
MAEBL; Provisional
 373-638 1.22e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  373 EAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASS---KREALEKTMRNKMDSEMRRLQDfN 449
Cdd:PTZ00121 1455 EAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEakkKADEAKKAEEAKKADEAKKAEE-A 1533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  450 RDLRERLESANRRLASKTQEAQAgsqdmVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQ---RRRAELLEQALGNAQGR 526
Cdd:PTZ00121 1534 KKADEAKKAEEKKKADELKKAEE-----LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaeeARIEEVMKLYEEEKKMK 1608

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  527 A--ARAEEELRKKQAYVEKVERLQQALGQLQAACE----KREQL---ELRLRTRLEQELKALRAQQRQAGAPGGSSGSGG 597
Cdd:PTZ00121 1609 AeeAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAeekkKAEELkkaEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEK 1688

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 522838240  598 SPELSALRLSEQLREKEEQILALEADMTKWEQ--KYLEERAMR 638
Cdd:PTZ00121 1689 KAAEALKKEAEEAKKAEELKKKEAEEKKKAEElkKAEEENKIK 1731
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 367-710 1.67e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 1.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   367 AHLAQMEAVLREnarLQRDNERLQRELESsAEKAGRIEKLESEIQ------RLSEAHESLTRASSKREALEkTMRNKMDS 440
Cdd:TIGR02168  186 ENLDRLEDILNE---LERQLKSLERQAEK-AERYKELKAELRELElallvlRLEELREELEELQEELKEAE-EELEELTA 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   441 EMRRLQDfnrDLrERLESANRRLASKTQEAQAGSQDMVAKLlaqsyeqqqeqekleremALLRGAIEDQRRRAELLEQal 520
Cdd:TIGR02168  261 ELQELEE---KL-EELRLEVSELEEEIEELQKELYALANEI------------------SRLEQQKQILRERLANLER-- 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   521 gNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEkREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPE 600
Cdd:TIGR02168  317 -QLEELEAQLEELESKLDELAEELAELEEKLEELKEELE-SLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   601 LSALRlsEQLREKEEQILALEADMTKWEQKYLEERamRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRH 680
Cdd:TIGR02168  395 IASLN--NEIERLEARLERLEDRRERLQQEIEELL--KKLEEAELKELQAELEELEEELEELQEELERLEEALEELREEL 470

                          330       340       350
                   ....*....|....*....|....*....|
gi 522838240   681 QEMESRLKVLHAQILEKDAVIKVLQQRSRR 710
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQARLDSLERLQEN 500
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 370-585 2.50e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 48.30  E-value: 2.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   370 AQMEAVLRENARLQRDNERLQR----ELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRR- 444
Cdd:pfam12128  312 AADAAVAKDRSELEALEDQHGAfldaDIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRd 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   445 LQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLlaqsyeqqqeqekleremallRGAIEDQRRRAELLEQALGNAQ 524
Cdd:pfam12128  392 IAGIKDKLAKIREARDRQLAVAEDDLQALESELREQL---------------------EAGKLEFNEEEYRLKSRLGELK 450

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 522838240   525 GRAARA---EEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKAL-----RAQQRQ 585
Cdd:pfam12128  451 LRLNQAtatPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALrqasrRLEERQ 519
PTZ00121 PTZ00121
MAEBL; Provisional
 367-634 9.15e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 9.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  367 AHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKL-ESEIQRLSEahesltrASSKREALEKTMRNKMDSEMRRL 445
Cdd:PTZ00121 1064 AHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAkKTETGKAEE-------ARKAEEAKKKAEDARKAEEARKA 1136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  446 QDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAieDQRRRAELLEQALGNAQG 525
Cdd:PTZ00121 1137 EDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKA--EDARKAEAARKAEEERKA 1214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  526 RAARAEEELRKKQAyVEKVERLQQALGQLQAACEKREQLELRlrtRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR 605
Cdd:PTZ00121 1215 EEARKAEDAKKAEA-VKKAEEAKKDAEEAKKAEEERNNEEIR---KFEEARMAHFARRQAAIKAEEARKADELKKAEEKK 1290

                         250       260
                  ....*....|....*....|....*....
gi 522838240  606 LSEQLREKEEQILALEADMTKWEQKYLEE 634
Cdd:PTZ00121 1291 KADEAKKAEEKKKADEAKKKAEEAKKADE 1319
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 499-630 9.25e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 499 MALLRGAIEDQRRRAELLEQALGNAQG---RAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE 575
Cdd:COG1196  634 AALRRAVTLAGRLREVTLEGEGGSAGGsltGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAE 713

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 522838240 576 LKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQK 630
Cdd:COG1196  714 EERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
369-541 1.02e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.91  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 369 LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALE--KTMRNKMDSEMRRLQ 446
Cdd:COG4717   70 LKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQelEALEAELAELPERLE 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 447 DFN------RDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQAL 520
Cdd:COG4717  150 ELEerleelRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEEL 229

                        170       180
                 ....*....|....*....|.
gi 522838240 521 GNAQGRAARAEEELRKKQAYV 541
Cdd:COG4717  230 EQLENELEAAALEERLKEARL 250
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
367-557 1.20e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 367 AHLAQMEAVLRENARLQRDNERLQRELESSAEkagRIEKLESEIQRLSEAHESLTRASSKREALE--KTMRNKMDSEMRR 444
Cdd:COG4717   71 KELKELEEELKEAEEKEEEYAELQEELEELEE---ELEELEAELEELREELEKLEKLLQLLPLYQelEALEAELAELPER 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 445 LQDFNRDLRErLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 524
Cdd:COG4717  148 LEELEERLEE-LRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELE 226

                        170       180       190
                 ....*....|....*....|....*....|...
gi 522838240 525 GRAARAEEELRKKQAYvekvERLQQALGQLQAA 557
Cdd:COG4717  227 EELEQLENELEAAALE----ERLKEARLLLLIA 255
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
369-539 1.86e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  369 LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK----------LESEIQRLSEAHESLTRASSKREALEKTmRNKM 438
Cdd:COG4913   619 LAELEEELAEAEERLEALEAELDALQERREALQRLAEyswdeidvasAEREIAELEAELERLDASSDDLAALEEQ-LEEL 697

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  439 DSEMRRLQDFNRDLRERLESANRRLASKTQEAQAgsqdmvAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRR--AELL 516
Cdd:COG4913   698 EAELEELEEELDELKGEIGRLEKELEQAEEELDE------LQDRLEAAEDLARLELRALLEERFAAALGDAVERelRENL 771

                         170       180
                  ....*....|....*....|...
gi 522838240  517 EQALGNAQGRAARAEEELRKKQA 539
Cdd:COG4913   772 EERIDALRARLNRAEEELERAMR 794
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
508-635 2.82e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  508 DQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQ----------AACEKREQLELRLR-------- 569
Cdd:COG4913   607 DNRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAeyswdeidvaSAEREIAELEAELErldassdd 686

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 522838240  570 -TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSAL-RLSEQLREKEEQILALEADMTKWEQKYLEER 635
Cdd:COG4913   687 lAALEEQLEELEAELEELEEELDELKGEIGRLEKELeQAEEELDELQDRLEAAEDLARLELRALLEER 754
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 502-710 7.76e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 7.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   502 LRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALrA 581
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL-E 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   582 QQRQAGAPGGSSGSGGSPELSALR--LSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRH 659
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIeeLEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRL 840

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 522838240   660 SPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRR 710
Cdd:TIGR02168  841 EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALAL 891
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 369-470 8.92e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 40.97  E-value: 8.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 369 LAQMEAVLRENARLQRDNERLQRELESsaeKAGRIEKLESEIQRlseahESLTRASSKREALEKTMRNKMDSEMRRLQDF 448
Cdd:COG2825   35 LQESPEGKAAQKKLEKEFKKRQAELQK---LEKELQALQEKLQK-----EAATLSEEERQKKERELQKKQQELQRKQQEA 106

                         90       100
                 ....*....|....*....|..
gi 522838240 449 NRDLRERLESANRRLASKTQEA 470
Cdd:COG2825  107 QQDLQKRQQELLQPILEKIQKA 128
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 376-571 9.42e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  376 LRENARL----QRDNERLQRELESsaekAGRIEKLESEIQRlseaheSLTRASSKREALEKTMRNKMDSEMRRLQDFN-R 450
Cdd:pfam17380 377 MRELERLqmerQQKNERVRQELEA----ARKVKILEEERQR------KIQQQKVEMEQIRAEQEEARQREVRRLEEERaR 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  451 DL-RERLESANR-----RLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 524
Cdd:pfam17380 447 EMeRVRLEEQERqqqveRLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQ 526

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 522838240  525 GRAA-----RAEEELRKKQAYVEKVERLQQalgQLQAACEKREQLELRLRTR 571
Cdd:pfam17380 527 KAIYeeerrREAEEERRKQQEMEERRRIQE---QMRKATEERSRLEAMERER 575
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 369-470 9.59e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 40.26  E-value: 9.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   369 LAQMEAVLRENARLQRDNERLQRELESSAEKagrIEKLESEIQRlseahESLTRASSKREALEKTMrNKMDSEMRRL-QD 447
Cdd:smart00935  10 LQESPAGKAAQKQLEKEFKKRQAELEKLEKE---LQKLKEKLQK-----DAATLSEAAREKKEKEL-QKKVQEFQRKqQK 80

                           90       100
                   ....*....|....*....|...
gi 522838240   448 FNRDLRERLESANRRLASKTQEA 470
Cdd:smart00935  81 LQQDLQKRQQEELQKILDKINKA 103
PTZ00121 PTZ00121
MAEBL; Provisional
 378-615 1.46e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  378 ENARLQRDNERLqrELESSAEKAGRIE--KLESEIQRLSEAH--ESLTRASSKREALE--KTMRNKMDSEMRRLQDFNRD 451
Cdd:PTZ00121 1143 EEARKAEDAKRV--EIARKAEDARKAEeaRKAEDAKKAEAARkaEEVRKAEELRKAEDarKAEAARKAEEERKAEEARKA 1220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  452 LRERLESANRRLASKTQEAQAGSQdmvAKLLAQSYEQQQEQEKLEREMALLRGAIE-DQRRRAELLEQALGNAQGRAARA 530
Cdd:PTZ00121 1221 EDAKKAEAVKKAEEAKKDAEEAKK---AEEERNNEEIRKFEEARMAHFARRQAAIKaEEARKADELKKAEEKKKADEAKK 1297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  531 EEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQL 610
Cdd:PTZ00121 1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAK 1377


                  ....*
gi 522838240  611 REKEE 615
Cdd:PTZ00121 1378 KKADA 1382
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 370-626 1.65e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.98  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  370 AQMEAVLRENARL--QRDNER-LQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRnkmdsemrrLQ 446
Cdd:pfam05622 218 EKLEALQKEKERLiiERDTLReTNEELRCAQLQQAELSQADALLSPSSDPGDNLAAEIMPAEIREKLIR---------LQ 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  447 DFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAE---LLEQALGNA 523
Cdd:pfam05622 289 HENKMLRLGQEGSYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEdssLLKQKLEEH 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240  524 QGRAARAEEELRKKQAYVEKVE-----RLQQALGQLQAACEKREQ----LELRLRTRLEQE---LKALRAQQRQagapgg 591
Cdd:pfam05622 369 LEKLHEAQSELQKKKEQIEELEpkqdsNLAQKIDELQEALRKKDEdmkaMEERYKKYVEKAksvIKTLDPKQNP------ 442

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 522838240  592 ssgsGGSPELSALRlsEQLREKEEQILALEADMTK 626
Cdd:pfam05622 443 ----ASPPEIQALK--NQLLEKDKKIEHLERDFEK 471
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 357-579 1.86e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   357 AQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRAsskREALEkTMRN 436
Cdd:TIGR02168  794 LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAE---IEELE-ELIE 869

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   437 KMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAkllaqsyeqqqeqekleremalLRGAIEDQRRRAELL 516
Cdd:TIGR02168  870 ELESELEALLNERASLEEALALLRSELEELSEELRELESKRSE----------------------LRRELEELREKLAQL 927

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838240   517 EQALGNAQGRAARAEEELRkkqayvEKVERLQQALGQLQAACE-KREQLELRLRtRLEQELKAL 579
Cdd:TIGR02168  928 ELRLEGLEVRIDNLQERLS------EEYSLTLEEAEALENKIEdDEEEARRRLK-RLENKIKEL 984
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
369-585 2.95e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.18  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 369 LAQMEAVLRENARLQRDNERLQRE---------------LESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKT 433
Cdd:PRK02224 428 EAELEATLRTARERVEEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA 507

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 434 MRNKMDSEMRR--LQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKllaqsyeqqqeqeklEREMALLRGAIEDQRR 511
Cdd:PRK02224 508 EDRIERLEERRedLEELIAERRETIEEKRERAEELRERAAELEAEAEEK---------------REAAAEAEEEAEEARE 572

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 522838240 512 RAELLEQALGNAQGRAaraeEELRKKQAYVEKVERLQQALGQLQaacEKREQLELRLRTRLEQeLKALRAQQRQ 585
Cdd:PRK02224 573 EVAELNSKLAELKERI----ESLERIRTLLAAIADAEDEIERLR---EKREALAELNDERRER-LAEKRERKRE 638
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 388-585 3.06e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 388 RLQRELESSAEKAGRIEKLESEIQRLSEAHESL-TRASSKREALEKtmrnkMDSEMRRLQDFNRDLRERLESANRRL--A 464
Cdd:COG1579   11 DLQELDSELDRLEHRLKELPAELAELEDELAALeARLEAAKTELED-----LEKEIKRLELEIEEVEARIKKYEEQLgnV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 465 SKTQEAQAgsqdmvakllaqsyeqqqeqekleremalLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQayvEKV 544
Cdd:COG1579   86 RNNKEYEA-----------------------------LQKEIESLKRRISDLEDEILELMERIEELEEELAELE---AEL 133

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 522838240 545 ERLQQALGQLQAACEKREQlelrlrtRLEQELKALRAQQRQ 585
Cdd:COG1579  134 AELEAELEEKKAELDEELA-------ELEAELEELEAEREE 167
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 357-614 4.40e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 40.98  E-value: 4.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   357 AQASSATSGSAHLAQMEAVLRE--NARLQRDNERLQRELESSAEKAGRI----------EKLESEIQRLSEAHESLTRAS 424
Cdd:pfam12128  405 ARDRQLAVAEDDLQALESELREqlEAGKLEFNEEEYRLKSRLGELKLRLnqatatpellLQLENFDERIERAREEQEAAN 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   425 SKREAL---EKTMRNKMDSEMRRLQDFNRDLRERlesANRRLASKTQ-EAQAGS------------QDMVAKLLAQSYEQ 488
Cdd:pfam12128  485 AEVERLqseLRQARKRRDQASEALRQASRRLEER---QSALDELELQlFPQAGTllhflrkeapdwEQSIGKVISPELLH 561

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   489 Q-----QEQEKLEREMALLRG--------------AIEDQ-RRRAELLEQALGNAQGRAARAEEEL-------------- 534
Cdd:pfam12128  562 RtdldpEVWDGSVGGELNLYGvkldlkridvpewaASEEElRERLDKAEEALQSAREKQAAAEEQLvqangelekasree 641

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240   535 -RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK 613
Cdd:pfam12128  642 tFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQ 721


                   .
gi 522838240   614 E 614
Cdd:pfam12128  722 V 722
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
367-635 5.90e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.14  E-value: 5.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 367 AHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDS------ 440
Cdd:COG4717  112 EELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQlslate 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 441 -EMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAI------------- 506
Cdd:COG4717  192 eELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALlallglggsllsl 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 507 -------------------EDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEK-----------VERLQQALGQLQA 556
Cdd:COG4717  272 iltiagvlflvlgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAAlglppdlspeeLLELLDRIEELQE 351

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 557 ACEKREQLELRLRT-RLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRlsEQLREKEEQILALEADMTKWEQKYLEER 635
Cdd:COG4717  352 LLREAEELEEELQLeELEQEIAALLAEAGVEDEEELRAALEQAEEYQELK--EELEELEEQLEELLGELEELLEALDEEE 429
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
370-580 9.70e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.66  E-value: 9.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 370 AQMEAVLRENARLQRDNERLQRELEssaekagrieKLESEIQRLSEAHESLTRASSKREALEKTMRnKMDSEMRRLQDFN 449
Cdd:PRK03918 200 KELEEVLREINEISSELPELREELE----------KLEKEVKELEELKEEIEELEKELESLEGSKR-KLEEKIRELEERI 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522838240 450 RDLRER---LESANRRLASKTQEAQAGSQdmVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGR 526
Cdd:PRK03918 269 EELKKEieeLEEKVKELKELKEKAEEYIK--LSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKK 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 522838240 527 AARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRlrtRLEQELKALR 580
Cdd:PRK03918 347 LKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPE---KLEKELEELE 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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