Mlxipl MLX interacting protein-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mlxiplprovided by MGI
Official Full Name: MLX interacting protein-likeprovided by MGI
Primary source: MGI:MGI:1927999
See related: Ensembl:ENSMUSG00000005373 AllianceGenome:MGI:1927999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mlx; ChREBP; WS-bHLH; Wbscr14; bHLHd14
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to DNA binding activity. Involved in glucose mediated signaling pathway; positive regulation of fatty acid biosynthetic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is active in nucleoplasm. Is expressed in several structures, including central nervous system; gut; liver; metanephros; and nose. Used to study irritable bowel syndrome. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 103.3), duodenum adult (RPKM 72.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.0 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (135118744..135168622)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (135089890..135139768)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNF4alpha is required for Tkfc promoter activation by ChREBP.
Title: HNF4α is required for Tkfc promoter activation by ChREBP.
Suppression of hepatic ChREBP-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH.
Title: Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH.
ChREBP plays a pivotal role in the nutrient-mediated regulation of metabolic gene expression in brown adipose tissue.
Title: ChREBP plays a pivotal role in the nutrient-mediated regulation of metabolic gene expression in brown adipose tissue.
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib.
Title: Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib.
Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy.
Title: Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy.
The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease.
Title: The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease.
Reactive oxygen species induce HNF-4alpha expression via the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in hepatocytes.
Title: Reactive oxygen species induce HNF-4α expression via the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in hepatocytes.
HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Title: HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
Title: Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.
Title: Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.

Submit: New GeneRIF Correction See all GeneRIFs (97)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wbscr14 (e-PCR), detects polymorphism
- UniSTS:230801

Wbscr14 (e-PCR), detects polymorphism
- UniSTS:230802

Mlxipl (e-PCR), detects polymorphism
- UniSTS:525501

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate response element binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carbohydrate-responsive element-binding protein

Names: MLX interacting protein-like beta; MLX interactor; Max-like protein; Williams-Beuren syndrome chromosome region 14 homolog; putative hepatic transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359237.1 → NP_001346166.1 carbohydrate-responsive element-binding protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC024607, AC084109

UniProtKB/TrEMBL

H9U1Q1

Conserved Domains (2) summary

cd00083
Location:483 → 543

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cl28033
Location:232 → 479

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
NM_021455.5 → NP_067430.2 carbohydrate-responsive element-binding protein isoform 1

See identical proteins and their annotated locations for NP_067430.2

Status: VALIDATED

Description

Transcript Variant: This variant (1, also known as zeta) encodes the longer isoform (1).

Source sequence(s)

AC024607

Consensus CDS

CCDS39316.1

UniProtKB/Swiss-Prot

Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q99MZ3, Q9JLM5

Related

ENSMUSP00000005507.4, ENSMUST00000005507.10

Conserved Domains (1) summary

cd00083
Location:660 → 720

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RNA

NR_152880.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as eta) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC024607, AF245476

Related

ENSMUST00000129008.5
NR_152881.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4, also known as iota) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC024607, AF245478

Related

ENSMUST00000153519.8
NR_152882.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5, also known as kappa) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC024607, AF245479

Related

ENSMUST00000128691.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

135118744..135168622

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504482.3 → XP_006504545.1 carbohydrate-responsive element-binding protein isoform X6

See identical proteins and their annotated locations for XP_006504545.1

Conserved Domains (2) summary

PHA03247
Location:192 → 495

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:506 → 621

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006504477.4 → XP_006504540.1 carbohydrate-responsive element-binding protein isoform X1

Conserved Domains (2) summary

PHA03247
Location:369 → 672

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:683 → 798

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006504480.3 → XP_006504543.1 carbohydrate-responsive element-binding protein isoform X4

Conserved Domains (2) summary

PHA03247
Location:369 → 672

PHA03247; large tegument protein UL36; Provisional

cd19689
Location:683 → 758

bHLHzip_MLXIPL; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins
XM_006504478.3 → XP_006504541.1 carbohydrate-responsive element-binding protein isoform X2

Conserved Domains (2) summary

PHA03307
Location:409 → 656

PHA03307; transcriptional regulator ICP4; Provisional

cl00081
Location:658 → 773

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006504479.3 → XP_006504542.1 carbohydrate-responsive element-binding protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:308 → 648

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:657 → 772

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006504481.3 → XP_006504544.1 carbohydrate-responsive element-binding protein isoform X5

Conserved Domains (2) summary

PHA03247
Location:308 → 648

PHA03247; large tegument protein UL36; Provisional

cd19689
Location:657 → 732

bHLHzip_MLXIPL; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins
XM_030254741.1 → XP_030110601.1 carbohydrate-responsive element-binding protein isoform X6

Conserved Domains (2) summary

PHA03247
Location:192 → 495

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:506 → 621

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily