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Conserved domains on  [gi|568938220|ref|XP_006504544|]
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carbohydrate-responsive element-binding protein isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 2.73e-87

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


:

Pssm-ID: 439287  Cd Length: 116  Bit Score: 272.61  E-value: 2.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  81 SIDPTLTHLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKP 160
Cdd:cd21771    1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568938220 161 EAVILEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21771   81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 657-732 5.61e-47

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


:

Pssm-ID: 381532  Cd Length: 76  Bit Score: 161.67  E-value: 5.61e-47
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568938220 657 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 732
Cdd:cd19689    1 KTETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 308-648 7.24e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  308 PPQTPTSSNYIESPSF-GPMADSLFSSGILAPEMPSPASSSSSSGMTPhSGNTRLQARNSCSGPLDPNPflssefllPED 386
Cdd:PHA03247 2704 PPPTPEPAPHALVSATpLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPPTTAGPPAPAP--------PAA 2774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  387 PKTkiPPAPGPTPLLPFPTPVKVHGL-EPCTPSPFPTMAPPPSllpeesllsARFPFTSAPPAPgvstLPAPTTFVPTPQ 465
Cdd:PHA03247 2775 PAA--GPPRRLTRPAVASLSESRESLpSPWDPADPPAAVLAPA---------AALPPAASPAGP----LPPPTSAQPTAP 2839

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  466 PGPgPVPFSVDHLPHGYLEPvFGPHFTVPQGMQPRCKPSSPS-PGGQKASPPTLASATASPTATATARDNNPcLTQLLRA 544
Cdd:PHA03247 2840 PPP-PGPPPPSLPLGGSVAP-GGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFALPPDQPERPP-QPQAPPP 2916

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  545 AKPEQALEPPTMPGTLLRPPESPDT--VSEIPRARAFFPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSER 622
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQPplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996

                         330       340
                  ....*....|....*....|....*...
gi 568938220  623 RLSGD--LNSIQPSGALSVHLSPPQTVL 648
Cdd:PHA03247 2997 TGHSLsrVSSWASSLALHEETDPPPVSL 3024
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 2.73e-87

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 272.61  E-value: 2.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  81 SIDPTLTHLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKP 160
Cdd:cd21771    1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568938220 161 EAVILEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21771   81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 657-732 5.61e-47

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 161.67  E-value: 5.61e-47
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568938220 657 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 732
Cdd:cd19689    1 KTETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
HLH pfam00010
Helix-loop-helix DNA-binding domain;
661-715 9.29e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 63.25  E-value: 9.29e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568938220  661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQ 715
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTL--PPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
668-717 4.12e-09

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 52.99  E-value: 4.12e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568938220   668 AEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQQE 717
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLPTL--PKNKKLSKAEILRLAIEYIKSLQEE 50
PHA03247 PHA03247
large tegument protein UL36; Provisional
 308-648 7.24e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  308 PPQTPTSSNYIESPSF-GPMADSLFSSGILAPEMPSPASSSSSSGMTPhSGNTRLQARNSCSGPLDPNPflssefllPED 386
Cdd:PHA03247 2704 PPPTPEPAPHALVSATpLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPPTTAGPPAPAP--------PAA 2774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  387 PKTkiPPAPGPTPLLPFPTPVKVHGL-EPCTPSPFPTMAPPPSllpeesllsARFPFTSAPPAPgvstLPAPTTFVPTPQ 465
Cdd:PHA03247 2775 PAA--GPPRRLTRPAVASLSESRESLpSPWDPADPPAAVLAPA---------AALPPAASPAGP----LPPPTSAQPTAP 2839

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  466 PGPgPVPFSVDHLPHGYLEPvFGPHFTVPQGMQPRCKPSSPS-PGGQKASPPTLASATASPTATATARDNNPcLTQLLRA 544
Cdd:PHA03247 2840 PPP-PGPPPPSLPLGGSVAP-GGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFALPPDQPERPP-QPQAPPP 2916

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  545 AKPEQALEPPTMPGTLLRPPESPDT--VSEIPRARAFFPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSER 622
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQPplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996

                         330       340
                  ....*....|....*....|....*...
gi 568938220  623 RLSGD--LNSIQPSGALSVHLSPPQTVL 648
Cdd:PHA03247 2997 TGHSLsrVSSWASSLALHEETDPPPVSL 3024
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 370-574 2.52e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  370 PLDPNPFLSSEFLLPedPKTKIPPAPGPTPLLpfptpvkvHGLEPCTPSPF--PTMAPPPSLLPEESLLSARFPFTSAPP 447
Cdd:pfam03154 344 PLPPAPLSMPHIKPP--PTTPIPQLPNPQSHK--------HPPHLSGPSPFqmNSNLPPPPALKPLSSLSTHHPPSAHPP 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  448 A----PGVSTLPAPTTFVPTPQPGPGPVPFSVDHLPHGYLEPV-----FGPHFTVPQG----MQPRCKPSSPSPGGQKAS 514
Cdd:pfam03154 414 PlqlmPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVpsqspFPQHPFVPGGpppiTPPSGPPTSTSSAMPGIQ 493

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  515 PPTLASATASPTATATARDNNPCLTqlLRAAKPEQALEPPTMPGTlLRPPESPDTVSEIP 574
Cdd:pfam03154 494 PPSSASVSSSGPVPAAVSCPLPPVQ--IKEEALDEAEEPESPPPP-PRSPSPEPTVVNTP 550
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 2.73e-87

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 272.61  E-value: 2.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  81 SIDPTLTHLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKP 160
Cdd:cd21771    1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568938220 161 EAVILEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21771   81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-194 1.23e-68

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 223.01  E-value: 1.23e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  81 SIDPTLTHLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGS-EADEHRK 159
Cdd:cd21772    1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSvDVDEHRR 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568938220 160 PEAVILEGNYWKRRIEVVMREYHKWRIYYKKRLRK 194
Cdd:cd21772   81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQK 115
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 81-196 7.41e-65

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 212.51  E-value: 7.41e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  81 SIDPTLTHLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLqgsEADEHRKP 160
Cdd:cd21739    1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQFAVPL---DDDTHKKP 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568938220 161 EAVILEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21739   78 EAVVLEGKYWKRRLETVVREYKKWRLFYKDKLAGKT 113
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 657-732 5.61e-47

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 161.67  E-value: 5.61e-47
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568938220 657 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 732
Cdd:cd19689    1 KTETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 659-732 2.45e-38

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 137.02  E-value: 2.45e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568938220 659 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 732
Cdd:cd11405    1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSLGQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 659-732 1.41e-31

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 117.74  E-value: 1.41e-31
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568938220 659 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSlkVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 732
Cdd:cd19688    1 KNRRMKHISAEQKRRFNIKICFDTLNSLVSTLKNSKP--ISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
 660-732 1.71e-17

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 77.46  E-value: 1.71e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568938220 660 NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQP---SLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 732
Cdd:cd19687    1 RRREAHTQAEQKRRDAIKKGYDDLQDIVPTCQQQDdigSQKLSKATILQRSIDYIQFLHQQKKKQEEELSALRKEV 76
HLH pfam00010
Helix-loop-helix DNA-binding domain;
661-715 9.29e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 63.25  E-value: 9.29e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568938220  661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQ 715
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTL--PPDKKLSKAEILRLAIEYIKHLQ 53
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 661-737 2.93e-12

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 62.95  E-value: 2.93e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEELNA 737
Cdd:cd11400    1 KRRLHNVLERQRRNDLKNSFEKLRDLVPELADNE--KASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRK 75
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 661-739 3.23e-12

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 62.32  E-value: 3.23e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQpslKVSKATTLQKTAEYIlmlqqerAAMQEEAQQLRDEIEELNAAI 739
Cdd:cd11404    2 RRLNHVRSEKKRRELIKKGYDELCALVPGLDPQ---KRTKADILQKAADWI-------QELKEENEKLEEQLDELKEAA 70
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 659-732 8.10e-12

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 61.97  E-value: 8.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 659 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQ-------------PSLKVSKATTLQKTAEYILMLQQERAAMQEEA 725
Cdd:cd11395    1 PRKRLPHNAIEKRYRSNLNTKIERLRDAIPSLRSPegksddgglgglaPTTKLSKATILTKAIEYIRHLEQENERLEEEN 80


                 ....*..
gi 568938220 726 QQLRDEI 732
Cdd:cd11395   81 EELRQQV 87
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 669-716 3.89e-11

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 58.69  E-value: 3.89e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568938220 669 EQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQ 716
Cdd:cd00083    1 ERRRRDKINDAFEELKRLLPELPDSK--KLSKASILQKAVEYIRELQS 46
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
 661-725 1.60e-09

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 54.67  E-value: 1.60e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEA 725
Cdd:cd11388    3 KKWKHVEAEKKRRNQIKKGFEDLINLINYPRNNNEKRISKSELLNKAVDDIRGLLKANEQLQEEI 67
HLH smart00353
helix loop helix domain;
668-717 4.12e-09

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 52.99  E-value: 4.12e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568938220   668 AEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQQE 717
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLPTL--PKNKKLSKAEILRLAIEYIKSLQEE 50
bHLH_scINO4_like cd11403
basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar ...
 661-725 7.37e-09

basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.


Pssm-ID: 381409  Cd Length: 71  Bit Score: 52.85  E-value: 7.37e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLkvSKATTLQKTAEYILMLQQERAAMQEEA 725
Cdd:cd11403    2 KKENHISSEHKRREAIREGFDRLCAIVPALSSSQSR--SEAVVYVKTVEYLKELYERRAKLRSQL 64
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
 661-729 3.06e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 48.12  E-value: 3.06e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQpslKVSKATTLQKTAEYILMLQQERAAMQEEAQQLR 729
Cdd:cd11406    1 KRAHHNALERKRRDHIKDSFHSLRDSVPSLQGE---KASRAQILKKATEYIQYMRRKNHTHQQDIDDLK 66
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 661-721 3.70e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 47.69  E-value: 3.70e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQpslKVSKATTLQKTAEYILMLQQERAAM 721
Cdd:cd11419    4 RREIANSNERRRMQSINAGFQSLRTLLPHCDGE---KLSKAAILQQTAEYIFSLEQEKTRL 61
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
 662-729 1.93e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 45.73  E-value: 1.93e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568938220 662 RITHISAEQKRRFNIKLGFDTLHGLVsTLSAQPslKVSKATTLQKTAEYILMLQQERAAMQEEAQQLR 729
Cdd:cd19682    1 RLRHKKRERERRSELRELFDKLKQLL-GLDSDE--KASKLAVLTEAIEEIQQLKREEDELQKEKARLT 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 308-648 7.24e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  308 PPQTPTSSNYIESPSF-GPMADSLFSSGILAPEMPSPASSSSSSGMTPhSGNTRLQARNSCSGPLDPNPflssefllPED 386
Cdd:PHA03247 2704 PPPTPEPAPHALVSATpLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPPTTAGPPAPAP--------PAA 2774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  387 PKTkiPPAPGPTPLLPFPTPVKVHGL-EPCTPSPFPTMAPPPSllpeesllsARFPFTSAPPAPgvstLPAPTTFVPTPQ 465
Cdd:PHA03247 2775 PAA--GPPRRLTRPAVASLSESRESLpSPWDPADPPAAVLAPA---------AALPPAASPAGP----LPPPTSAQPTAP 2839

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  466 PGPgPVPFSVDHLPHGYLEPvFGPHFTVPQGMQPRCKPSSPS-PGGQKASPPTLASATASPTATATARDNNPcLTQLLRA 544
Cdd:PHA03247 2840 PPP-PGPPPPSLPLGGSVAP-GGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFALPPDQPERPP-QPQAPPP 2916

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  545 AKPEQALEPPTMPGTLLRPPESPDT--VSEIPRARAFFPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSER 622
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQPplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996

                         330       340
                  ....*....|....*....|....*...
gi 568938220  623 RLSGD--LNSIQPSGALSVHLSPPQTVL 648
Cdd:PHA03247 2997 TGHSLsrVSSWASSLALHEETDPPPVSL 3024
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 661-737 2.71e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 43.48  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAqpslKVSKATTLQKTAEYILMLQQERAAMQEEAQ-------QLRDEIE 733
Cdd:cd11398    7 RRDNHKEVERRRRENINEGINELAALVPGNAR----EKNKGAILARAVEYIQELQETEAKNIEKWTleklltdQAIAELA 82


                 ....
gi 568938220 734 ELNA 737
Cdd:cd11398   83 ALNE 86
bHLHzip_c-Myc cd11458
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, ...
 657-735 3.62e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.


Pssm-ID: 381464 [Multi-domain]  Cd Length: 84  Bit Score: 42.95  E-value: 3.62e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568938220 657 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEEL 735
Cdd:cd11458    1 EENDKRRTHNVLERQRRNELKLSFFALRDQIPEVANNE--KAPKVVILKKATEYILSMQADEQRLISEKEQLRRRREQL 77
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 665-722 5.78e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 41.40  E-value: 5.78e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568938220 665 HISAEQKRRFNIKLGFDTLHGLVStlsaqPSLKVSKATTLQKTAEYILMLQQERAAMQ 722
Cdd:cd11393    1 HSIAERKRREKINERIRALRSLVP-----NGGKTDKASILDEAIEYIKFLQEQVKVLS 53
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
 656-717 8.46e-05

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 41.05  E-value: 8.46e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568938220 656 NKMENRRITHISaeqkrrfnikLGFDTLHGLVSTLSaqPSLKVSKATTLQKTAEYILMLQQE 717
Cdd:cd11418    6 NERERRRVQAVN----------DAFDRLRQHVPYLK--RRKKLSKVKTLRRAIEYIRHLQKL 55
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
 662-729 9.29e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 41.29  E-value: 9.29e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568938220 662 RITHISAEQKRRFNIKLGFDTLHGLvstLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLR 729
Cdd:cd19690    1 RVSHKLAERKRRKEMKELFEDLRDA---LPQERGTKASKWEILTKAISYIQQLKRHIRELRSEVNDLR 65
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 657-741 1.02e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 41.96  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 657 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRdEIEELN 736
Cdd:cd18928    7 KERQKKDNHNLIERRRRFNINDRIKELGTLIPK-STDPEMRWNKGTILKASVDYIRKLQKEQQRSKEIEMRQR-KLEQAN 84


                 ....*
gi 568938220 737 AAINL 741
Cdd:cd18928   85 RSLQL 89
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
 661-735 1.48e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 41.43  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQ-------QERAAMQEEAQQLRDEIE 733
Cdd:cd11456    5 RRRNHNILERQRRNDLRSSFLTLRDHVPELVKNE--KAAKVVILKKATEYVHSLQaeeqkllLEKEKLQARQQQLLKKIE 82


                 ..
gi 568938220 734 EL 735
Cdd:cd11456   83 QA 84
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 370-574 2.52e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  370 PLDPNPFLSSEFLLPedPKTKIPPAPGPTPLLpfptpvkvHGLEPCTPSPF--PTMAPPPSLLPEESLLSARFPFTSAPP 447
Cdd:pfam03154 344 PLPPAPLSMPHIKPP--PTTPIPQLPNPQSHK--------HPPHLSGPSPFqmNSNLPPPPALKPLSSLSTHHPPSAHPP 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  448 A----PGVSTLPAPTTFVPTPQPGPGPVPFSVDHLPHGYLEPV-----FGPHFTVPQG----MQPRCKPSSPSPGGQKAS 514
Cdd:pfam03154 414 PlqlmPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVpsqspFPQHPFVPGGpppiTPPSGPPTSTSSAMPGIQ 493

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  515 PPTLASATASPTATATARDNNPCLTqlLRAAKPEQALEPPTMPGTlLRPPESPDTVSEIP 574
Cdd:pfam03154 494 PPSSASVSSSGPVPAAVSCPLPPVQ--IKEEALDEAEEPESPPPP-PRSPSPEPTVVNTP 550
PHA03247 PHA03247
large tegument protein UL36; Provisional
 411-622 2.70e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  411 GLEPCTPSPFPTMAPPPSLLPEESLLSARFPFT-----------------SAPPAPGVSTLPAPTTFVPTPQPGP---GP 470
Cdd:PHA03247 2501 GGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMltwirgleelasddagdPPPPLPPAAPPAAPDRSVPPPRPAPrpsEP 2580

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  471 VPFSVDHLPHGYLEPVFGPHFTVPQGMQPRCKPSSPSP----------------------GGQKASPPTLASATASPTAT 528
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPpdthapdppppspspaanepdpHPPPTVPPPERPRDDPAPGR 2660

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  529 ATARDNNPCLTQLLRAAKPEQALEPPTMPGT------LLRPPESPDTVSEIPRARAFFPPIPAPTPPRPPPGPATL---- 598
Cdd:PHA03247 2661 VSRPRRARRLGRAAQASSPPQRPRRRAARPTvgsltsLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaapa 2740

                         250       260
                  ....*....|....*....|....*...
gi 568938220  599 --APPRSLVVPKAER--LSPPASSGSER 622
Cdd:PHA03247 2741 ppAVPAGPATPGGPArpARPPTTAGPPA 2768
PHA03378 PHA03378
EBNA-3B; Provisional
 415-650 3.03e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 415 CTPSPFPTmaPPPSLLPEESLLSARFPFTSAPpapgvSTLPAPTTFVPTPQPGPGPVPFSVDHLPHGYLEPVFGPHFTVP 494
Cdd:PHA03378 592 YAQTPWPV--PHPSQTPEPPTTQSHIPETSAP-----RQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKP 664

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 495 QGMQPRCKPSSPSPGGQKASpptlasatasptatatardnnpcltqLLRAAKPEQALEPPTMPGTlLRPPESPDTVSEIP 574
Cdd:PHA03378 665 TWTQIGHIPYQPSPTGANTM--------------------------LPIQWAPGTMQPPPRAPTP-MRPPAAPPGRAQRP 717

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568938220 575 RAraffppipaptpprpppgPATLAPPRSLVVPKAERlsPPASSGSERRLSGDLNSIQPSGALSVHLSPPQTVLSR 650
Cdd:PHA03378 718 AA------------------ATGRARPPAAAPGRARP--PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGA 773
bHLHzip_scHMS1_like cd11399
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription ...
 660-735 3.41e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.


Pssm-ID: 381405 [Multi-domain]  Cd Length: 96  Bit Score: 40.54  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 660 NRRITHIS-------AEQKRRFNIKLGFDTLHGLvstlsaQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 732
Cdd:cd11399   19 NDRIAELRdsvpalrEAYKSARGEDEDEEDLGGL------TPATKLNKATILSKATEYIRHLEKKNKRLSRENASLRERL 92


                 ...
gi 568938220 733 EEL 735
Cdd:cd11399   93 AAH 95
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
 661-715 4.05e-04

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 39.26  E-value: 4.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAqpslKVSKATTLQKTAEYILMLQ 715
Cdd:cd19683    2 SRERHNAKERQRRERIKIACDQLRKLVPGCSR----KTDKATVFEFTVAYIKFLR 52
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 409-655 7.92e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 7.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  409 VHGLEPCTPSPFPTMAPP-------------PSLLPEESLLSARFPFTSAPPAPGVSTLPAPTTFVPTPQPGPGPVPFSV 475
Cdd:PHA03307   56 VAGAAACDRFEPPTGPPPgpgteapanesrsTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLS 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  476 DHLPHGYLEPVFGPHFTVPQGMQPRCKPSSPSPGGQKASPptLASATASPTATATARDNNPCLTQLLRAAKPEQALEPPT 555
Cdd:PHA03307  136 EMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP--LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPI 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  556 MPGTLLRPPESPDTVSEIPRARAFFPPIPAPTPPRPPPGPATLAPPRSLVV------------PKAERLSPPASSGSERR 623
Cdd:PHA03307  214 SASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITlptriweasgwnGPSSRPGPASSSSSPRE 293

                         250       260       270
                  ....*....|....*....|....*....|..
gi 568938220  624 LSGDLNSIQPSGALSVhlSPPQTVLSRGRVDN 655
Cdd:PHA03307  294 RSPSPSPSSPGSGPAP--SSPRASSSSSSSRE 323
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 657-738 8.34e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 39.29  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 657 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQEraamQEEAQQLRDEIEELN 736
Cdd:cd18925    1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPK-SNDPDMRWNKGTILKASVEYIKWLQKE----QQRARELEHRQKKLE 75


                 ..
gi 568938220 737 AA 738
Cdd:cd18925   76 QA 77
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 661-729 9.24e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400 [Multi-domain]  Cd Length: 73  Bit Score: 38.41  E-value: 9.24e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568938220 661 RRITHISAEQKRRFNIKLGFDTLHGLVstlsAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLR 729
Cdd:cd11394    6 KRSAHNAIEKRYRSSINDRIIELKDLV----VGPDAKMNKSAVLRKAIDYIRYLQKVNQKLKQENMALK 70
PHA03247 PHA03247
large tegument protein UL36; Provisional
 417-648 1.10e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  417 PSPFPTMAPPPSLLPEESLLSARFPFTSAPPAPGvsTLPAPTTFVPTPQPGPGPVPFSVDHLPHGYLEPVFGPhftvPQG 496
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHP--PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP----PQR 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  497 MQPRCKPSSPSPGGQKASPPTLASATASPTATATARDNNPCLTQLLRAAKPEQALEP--------PTMPGTLLRPPeSPD 568
Cdd:PHA03247 2683 PRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPappavpagPATPGGPARPA-RPP 2761

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  569 TVSEIPRARAffppipAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSERRLSGDLNSIQPSGALSVHLSPPQTVL 648
Cdd:PHA03247 2762 TTAGPPAPAP------PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835
PHA03247 PHA03247
large tegument protein UL36; Provisional
 384-653 1.70e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  384 PEDPKTKIPPAPGPTPLLPFPTPVKVHGLEPCTP-SPFPTMAPPPSLLPEESLLSARFPFTSAPPAPGVSTLPAPTTFVP 462
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  463 TPQPGPGPVPFSVDHLPH-----GYLEPVFGPHFTVPQGMQPRCKPSSPSPGGQKASPPTLASATASPTATATARDNNPc 537
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSpwdpaDPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD- 2861

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  538 ltqlLRAAKPEQAlePPTMPGTLLRPPESPDTVSEIPRARAFFPPIPAPTPPRPPPGPATLA-PPRSLVVPKAERLSPPA 616
Cdd:PHA03247 2862 ----VRRRPPSRS--PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPqPQPQPPPPPQPQPPPPP 2935

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 568938220  617 SSGSERRLSGDLNSIQPSGALSVHLSPPQTVLSRGRV 653
Cdd:PHA03247 2936 PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRV 2972
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
 657-738 1.73e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 38.91  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 657 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQEraamQEEAQQLRDEIEELN 736
Cdd:cd18926    9 KERQKKDNHNLIERRRRFNINDRIKELGTLIPK-SNDPDMRWNKGTILKASVDYIRKLQRE----QQRAKELENRQKKLE 83


                 ..
gi 568938220 737 AA 738
Cdd:cd18926   84 HA 85
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
387-568 2.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 387 PKTKIPPAPGPTPLLPFPTPVKVHGLEPCTPSPFPtMAPPPSLLPEESLLSARFPFTSAPPAPGVSTLPAPTTFVPTPQP 466
Cdd:PRK12323 391 APAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPAR-RSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGP 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220 467 GPGPVPFSVDHLPHGYLEPVFGPHFTVPQGMQPRCKPSSPSPGGQKASPPTLASATASPTATATARDNNPCLTqllrAAK 546
Cdd:PRK12323 470 RPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLA----PAP 545

                        170       180
                 ....*....|....*....|..
gi 568938220 547 PEQALEPPTMPGTLLRPPESPD 568
Cdd:PRK12323 546 AAAPAPRAAAATEPVVAPRPPR 567
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 664-717 3.13e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 36.46  E-value: 3.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568938220 664 THISAEQKRRFNIKLGFDTLHGLV-STLSAQPSLKVSKATTLQKTAEYILMLQQE 717
Cdd:cd11387    1 SHNAVERRRRDNINEKIQELGSLVpPSRLETKDLKPNKGSILSKAVEYIRELQNQ 55
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 307-644 4.76e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  307 RPPQTPTSSNYIESPSFGPMADSLFSSGI-------LAPEMPSPASSSSSSGMTPHSGNTRLQARNSCSGPLDPNPFLSS 379
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPPPGTTQAATAGptpsapsVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  380 EFLLPEDPKTKIPPAPGPTPLLPFPTPVKVHGLEPcTPSPFPTMAPPPSLLPEESLLSARFPFTSAPPAPG----VSTLP 455
Cdd:pfam03154 250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQT-GPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGqsqqRIHTP 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  456 APTTFVPTPQPGPG----PVPFSVDHLPHGYLEPVfgPHFTVPQGMQPRCKPSSPSPGGQKAS-PPTLASATASPTATAT 530
Cdd:pfam03154 329 PSQSQLQSQQPPREqplpPAPLSMPHIKPPPTTPI--PQLPNPQSHKHPPHLSGPSPFQMNSNlPPPPALKPLSSLSTHH 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938220  531 ARDNNPCLTQLLRAAKPEQAlePPTMPGTLLRPPESPDTVSEIPRARAFFPPIPAPTPprpppgpatlaPPRSLVVPKAE 610
Cdd:pfam03154 407 PPSAHPPPLQLMPQSQQLPP--PPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPF-----------PQHPFVPGGPP 473

                         330       340       350
                  ....*....|....*....|....*....|....
gi 568938220  611 RLSPPasSGSERRLSGDLNSIQPSGALSVHLSPP 644
Cdd:pfam03154 474 PITPP--SGPPTSTSSAMPGIQPPSSASVSSSGP 505
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
 662-716 6.76e-03

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 35.63  E-value: 6.76e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568938220 662 RITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQQ 716
Cdd:cd11390    1 RNAANARERRRMHDLNDAFEALRKVLPTV--PPDKKLSKIETLRLAINYIAALSD 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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