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    dom domino [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45655, updated on 28-Oct-2024

    Summary

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    Official Symbol
    domprovided by FlyBase
    Official Full Name
    dominoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020306
    Locus tag
    Dmel_CG9696
    See related
    AllianceGenome:FB:FBgn0020306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    27/4; anon-WO0172774.190; CG9696; dDom; dEP400; Dmel\CG9696; Dom; DOM; DOM-A; DomA; Domino; l(2)81/8; l(2)k02704; l(2)k08108; p400
    Summary
    Enables ATP-dependent H2AZ histone chaperone activity. Involved in several processes, including chromatin remodeling; dendrite guidance; and male germ-line stem cell population maintenance. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Is expressed in several structures, including adult optic lobe; embryonic/larval salivary gland; eye disc posterior to the morphogenetic furrow; germline cell; and presumptive embryonic/larval system. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See dom in Genome Data Viewer
    Location:
    57D11-57D12; 2-94 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21323430..21341847)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17210935..17229352)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene small non-coding RNA 184 Neighboring gene Bardet-Biedl syndrome 9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ATPase SRCAP is associated with the mitotic apparatus, uncovering novel molecular aspects of Floating-Harbor syndrome. Messina G, et al. BMC Biol, 2021 Sep 2. PMID 34474679, Free PMC Article
    2. Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. Liu Z, et al. PLoS Genet, 2019 Oct. PMID 31658266, Free PMC Article
    3. Expression pattern of Filamin-240 in Drosophila blood cells. Rus F, et al. Gene Expr Patterns, 2006 Oct. PMID 16616709
    4. Histone variant H2A.Z regulates zygotic genome activation. Ibarra-Morales D, et al. Nat Commun, 2021 Dec 1. PMID 34853314, Free PMC Article
    5. Fat-body remodeling in Drosophila melanogaster. Nelliot A, et al. Genesis, 2006 Aug. PMID 16868920

    See all (175) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster.
      Title: Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster.
    2. Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms.
      Title: Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms.
    3. Study identified the Drosophila SWI2/SNF2 protein DOMINO (DOM) as a key regulator of circadian behavior. Depletion of DOM in circadian neurons eliminates morning anticipatory activity under light dark cycle and impairs behavioral rhythmicity in constant darkness. Interestingly, the two major splice variants of DOM, DOM-A and DOM-B have distinct circadian functions.
      Title: Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance.
    4. Dom acts pleiotropically as a positive effector of Notch signaling and a repressor of proliferation.
      Title: A targeted genetic modifier screen links the SWI2/SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster.
    5. DOM is implicated in developmental gene activation
      Title: Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.
    6. the roles of dom and iswi in germ line stem cell and somatic stem cell regulation
      Title: Stem cell self-renewal controlled by chromatin remodeling factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP-dependent activity, acting on DNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone chaperone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemopoiesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in male germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hemocyte proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    domino
    Names
    CG9696-PA
    CG9696-PD
    CG9696-PE
    CG9696-PG
    Domino-A
    dom-PA
    dom-PD
    dom-PE
    dom-PG
    domino DNA dependent ATPase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21323430..21341847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299747.1 → NP_001286676.1  domino, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFX8, B5RJR0
      Conserved Domains (6) summary
      smart00573
      Location:543 → 614
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:969 → 1108
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:952 → 1238
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1692 → 1806
      Helicase_C; Helicase conserved C-terminal domain
      pfam14851
      Location:824 → 868
      FAM176; FAM176 family
      cl22451
      Location:674 → 831
      ASF1_hist_chap; ASF1 like histone chaperone

    2. NM_080094.4 → NP_524833.2  domino, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524833.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YZ94, Q95TN6, Q968U6, Q9I7V8, Q9NDJ2
      UniProtKB/TrEMBL
      B5RJR0
      Related
      FBpp0071529
      Conserved Domains (6) summary
      smart00573
      Location:508 → 579
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:934 → 1073
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:917 → 1203
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1657 → 1771
      Helicase_C; Helicase conserved C-terminal domain
      pfam14851
      Location:789 → 833
      FAM176; FAM176 family
      cl22451
      Location:639 → 796
      ASF1_hist_chap; ASF1 like histone chaperone

    3. NM_166446.3 → NP_726065.1  domino, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJR0, Q8MLW2
      Related
      FBpp0071528
      Conserved Domains (6) summary
      smart00573
      Location:508 → 579
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:934 → 1073
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:917 → 1203
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1657 → 1771
      Helicase_C; Helicase conserved C-terminal domain
      pfam14851
      Location:789 → 833
      FAM176; FAM176 family
      cl22451
      Location:639 → 796
      ASF1_hist_chap; ASF1 like histone chaperone

    4. NM_176244.3 → NP_788424.1  domino, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788424.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NDJ2
      Related
      FBpp0071530
      Conserved Domains (6) summary
      smart00573
      Location:508 → 579
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:934 → 1073
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:917 → 1203
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1657 → 1771
      Helicase_C; Helicase conserved C-terminal domain
      pfam14851
      Location:789 → 833
      FAM176; FAM176 family
      cl22451
      Location:639 → 769
      ASF1_hist_chap; ASF1 like histone chaperone
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFX8 A0A0B4LFX8
    Q8MLW2 Q8MLW2
    Q8MT92 Q8MT92
    Q960W1 Q960W1
    Q9NDJ2.2 Q9NDJ2

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