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    Pdia2 protein disulfide isomerase associated 2 [ Mus musculus (house mouse) ]

    Gene ID: 69191, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pdia2provided by MGI
    Official Full Name
    protein disulfide isomerase associated 2provided by MGI
    Primary source
    MGI:MGI:1916441
    See related
    Ensembl:ENSMUSG00000024184 AllianceGenome:MGI:1916441
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdip; Pdipl; 1810041F13Rik
    Summary
    Predicted to enable protein-disulfide reductase activity. Acts upstream of or within platelet aggregation. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in lens; lens epithelium; lens fiber; lens vesicle; and lens vesicle epithelium. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 77.1), small intestine adult (RPKM 48.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pdia2 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.07 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26414973..26418108, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26195999..26199134, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5580 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene STARR-positive B cell enhancer ABC_E7501 Neighboring gene axin 1 Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene regulator of G-protein signaling 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a pancreas-specific protein disulfide isomerase, PDIp. Desilva MG, et al. DNA Cell Biol, 1997 Mar. PMID 9115635
    2. Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait. Lan H, et al. Diabetes, 2004 Jan. PMID 14693722
    3. Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions. Fu XM, et al. J Mol Histol, 2009 Jun. PMID 19821078
    4. Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase. Toldo S, et al. Mol Med, 2011 Sep-Oct. PMID 21637911, Free PMC Article
    5. [Interaction of rotavirus with protein disulfide isomerase in vitro and cell system]. Calderón MN, et al. Biomedica, 2011 Mar. PMID 22159485

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rotavirus-protein disulfide isomerase interaction was demonstrated in vitro as well as inMA104 cells and intestinal villi from suckling mice.
      Title: [Interaction of rotavirus with protein disulfide isomerase in vitro and cell system].
    2. Data show that diabetic mice had a worse postinfarction remodeling associated with an altered protein disulfide isomerase (PDI). redox state.
      Title: Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase.
    3. The absence of PDIp expression in pancreatic adenocarcinoma may serve as an additional biomarker for pancreatic cancer.
      Title: Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.
    4. Elevated Pdi expression is cis regulated and is not linked to diabetes susceptibility.
      Title: Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144891

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase A2
    Names
    protein disulfide isomerase (pancreas) like
    protein disulfide isomerase, pancreatic
    NP_001074539.1
    XP_006524935.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081070.1 → NP_001074539.1  protein disulfide-isomerase A2 precursor

      See identical proteins and their annotated locations for NP_001074539.1

      Status: PROVISIONAL

      Source sequence(s)
      AC126438
      Consensus CDS
      CCDS37510.1
      UniProtKB/Swiss-Prot
      D3Z6P0, Q14AV9
      Related
      ENSMUSP00000035584.8, ENSMUST00000039113.14
      Conserved Domains (5) summary
      cd02961
      Location:48 → 150
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      cd02981
      Location:158 → 257
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:262 → 371
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:392 → 494
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      TIGR01130
      Location:45 → 506
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26414973..26418108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524872.2 → XP_006524935.1  protein disulfide-isomerase A2 isoform X1

      Conserved Domains (1) summary
      TIGR01130
      Location:45 → 467
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z6P0.1 GenPept UniProtKB/Swiss-Prot:D3Z6P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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