ITGB2 integrin subunit beta 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ITGB2provided by HGNC
Official Full Name: integrin subunit beta 2provided by HGNC
Primary source: HGNC:HGNC:6155
See related: Ensembl:ENSG00000160255 MIM:600065; AllianceGenome:HGNC:6155
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Summary: This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression: Broad expression in bone marrow (RPKM 117.8), appendix (RPKM 80.8) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q22.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (44885953..44928815, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (43246634..43289593, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (46305868..46348730, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta2-integrins control HIF1alpha activation in human neutrophils.
Title: β(2)-integrins control HIF1α activation in human neutrophils.
Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.
Title: Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.
ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.
Title: ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.
Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.
Title: Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.
Identification of an association between coronary heart disease and ITGB2 methylation in peripheral blood by a case-control study.
Title: Identification of an association between coronary heart disease and ITGB2 methylation in peripheral blood by a case-control study.
Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.
Title: Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.
Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types.
Title: Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types.
Association of integrin-beta2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.
Title: Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.
Targeting Neutrophil beta2-Integrins: A Review of Relevant Resources, Tools, and Methods.
Title: Targeting Neutrophil β(2)-Integrins: A Review of Relevant Resources, Tools, and Methods.
Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis.
Title: Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis.

Submit: New GeneRIF Correction See all GeneRIFs (397)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Leukocyte adhesion deficiency 1 MedGen: C0398738 OMIM: 116920 GeneReviews: Not available	Compare labs

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 is identified to have a physical interaction with integrin, beta 2 (ITGB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
	env	Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1	PubMed
	env	HIV-1 gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with ITGB2 (CD18); predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix	PubMed
	env	HIV-1 gp160 is identified to have a physical interaction with integrin, beta 2 (ITGB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Tat	tat	HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins	PubMed
	tat	HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP	PubMed
	tat	HIV-1 Tat inhibits calcium influx and impairs CAMKII activation elicited via LFA-1 (beta 2 integrin) in NK cells	PubMed
	tat	HIV-1 Tat treatment of monocytes upregulates beta 2 integrins and anti-beta 2 Abs inhibits Tat induced adhesion of monocytes to endothelial monolayers, suggesting a mechanism where monocytes could be inappropriately activated by HIV-1 Tat	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 2 (ITGB2, complement component 3 receptor 3 and 4) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
matrix	gag	HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:185175 (e-PCR)
- UniSTS:155430

RH93593 (e-PCR)
- UniSTS:92737

G60035 (e-PCR)
- UniSTS:137301

SHGC-132463 (e-PCR)
- UniSTS:173911

SHGC-87704 (e-PCR)
- UniSTS:36235

G44333 (e-PCR)
- UniSTS:95120

GDB:181564 (e-PCR)
- UniSTS:155290

STS-M15395 (e-PCR)
- UniSTS:28058

ITGB2_2800 (e-PCR)
- UniSTS:462282

SHGC-32286 (e-PCR)
- UniSTS:6860

GDB:373059 (e-PCR)
- UniSTS:156893

PMC129056P1 (e-PCR)
- UniSTS:270585

PMC129056P2 (e-PCR)
- UniSTS:270586

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ICAM-3 receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables cell adhesion molecule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables complement component C3b binding	ISS Inferred from Sequence or Structural Similarity more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	NAS Non-traceable Author Statement more info	PubMed
enables integrin binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular extravasation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in endodermal cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte migration involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of dopamine metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil degranulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of prostaglandin-E synthase activity	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein targeting to membrane	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of superoxide anion generation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of superoxide anion generation	NAS Non-traceable Author Statement more info	PubMed
involved_in receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	HDA more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular vesicle	HDA more info	PubMed
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alphaL-beta2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphaL-beta2 complex	NAS Non-traceable Author Statement more info	PubMed
part_of integrin alphaM-beta2 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alphaM-beta2 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of integrin alphaX-beta2 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alphaX-beta2 complex	TAS Traceable Author Statement more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in specific granule membrane	TAS Traceable Author Statement more info
located_in tertiary granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: integrin beta-2

Names: cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; integrin beta chain, beta 2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007270.2 RefSeqGene

Range

4966..47886

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_76

mRNA and Protein(s)

NM_000211.5 → NP_000202.3 integrin beta-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_000202.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK095992, AK222505, CA447686, M15395

Consensus CDS

CCDS13716.1

UniProtKB/Swiss-Prot

B3KTS8, D3DSM1, P05107, Q16418, Q53HS5, Q9UD72

UniProtKB/TrEMBL

A0A494C0X7, A0AAA9WZN5

Related

ENSP00000498780.1, ENST00000652462.1

Conserved Domains (3) summary

smart00187
Location:32 → 447

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:622 → 699

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:726 → 767

Integrin_b_cyt; Integrin beta cytoplasmic domain
NM_001127491.3 → NP_001120963.2 integrin beta-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001120963.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK095992, AL844908, CA447686, M15395

Consensus CDS

CCDS13716.1

UniProtKB/Swiss-Prot

B3KTS8, D3DSM1, P05107, Q16418, Q53HS5, Q9UD72

UniProtKB/TrEMBL

A0A494C0X7, A0AAA9WZN5

Related

ENSP00000347279.4, ENST00000355153.8

Conserved Domains (3) summary

smart00187
Location:32 → 447

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:622 → 699

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:726 → 767

Integrin_b_cyt; Integrin beta cytoplasmic domain
NM_001303238.2 → NP_001290167.1 integrin beta-2 isoform 2

See identical proteins and their annotated locations for NP_001290167.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has a shorter 5' UTR, uses an alternate splice site in the 5' region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK303488, AU279404, CA447686, M15395

UniProtKB/TrEMBL

A0AAA9WZN5, B4E0R1

Conserved Domains (3) summary

smart00187
Location:1 → 378

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:553 → 630

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:657 → 697

Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p14 Primary Assembly

Range

44885953..44928815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006724001.3 → XP_006724064.1 integrin beta-2 isoform X1

See identical proteins and their annotated locations for XP_006724064.1

UniProtKB/TrEMBL

A0AAA9WZN5, B4E0R1

Conserved Domains (3) summary

smart00187
Location:1 → 378

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:553 → 630

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:657 → 697

Integrin_b_cyt; Integrin beta cytoplasmic domain
XM_047440763.1 → XP_047296719.1 integrin beta-2 isoform X1

UniProtKB/TrEMBL

B4E0R1