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    Gatd1 glutamine amidotransferase like class 1 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 213350, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gatd1provided by MGI
    Official Full Name
    glutamine amidotransferase like class 1 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2387178
    See related
    Ensembl:ENSMUSG00000051007 AllianceGenome:MGI:2387178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fy-5; Pddc1; D230016J19Rik
    Summary
    Predicted to enable glyoxalase III activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Predicted to be located in early endosome and extracellular region. Predicted to be active in cytoplasm. Orthologous to human GATD1 (glutamine amidotransferase class 1 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 47.2), genital fat pad adult (RPKM 37.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gatd1 in Genome Data Viewer
    Location:
    7 F5; 7 86.75 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140988097..140994038, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141408184..141414125, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8223 Neighboring gene transaldolase 1 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3761 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Neighboring gene STARR-positive B cell enhancer ABC_E4986

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC38368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glyoxalase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamine amidotransferase-like class 1 domain-containing protein 1
    Names
    Parkinson disease 7 domain containing 1
    ferry endosomal RAB5 effector complex subunit 5
    parkinson disease 7 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172116.4 → NP_742114.3  glutamine amidotransferase-like class 1 domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_742114.3

      Status: VALIDATED

      Source sequence(s)
      AK081187, AK084273, AK140975, BY118625
      Consensus CDS
      CCDS52444.1
      UniProtKB/Swiss-Prot
      Q8BFQ8, Q8C2Q9
      Related
      ENSMUSP00000101630.2, ENSMUST00000106008.3
      Conserved Domains (2) summary
      cd03141
      Location:12 → 216
      GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
      COG0693
      Location:31 → 204
      ThiJ; Putative intracellular protease/amidase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140988097..140994038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536171.3 → XP_006536234.2  glutamine amidotransferase-like class 1 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      cd03141
      Location:12 → 201
      GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFQ8.1 GenPept UniProtKB/Swiss-Prot:Q8BFQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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