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    Lcn5 lipocalin 5 [ Mus musculus (house mouse) ]

    Gene ID: 13863, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lcn5provided by MGI
    Official Full Name
    lipocalin 5provided by MGI
    Primary source
    MGI:MGI:1277241
    See related
    Ensembl:ENSMUSG00000026937 AllianceGenome:MGI:1277241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erabp; MEP10; E-RABP
    Summary
    This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 713.9) See more
    Orthologs
    all
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    Genomic context

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    See Lcn5 in Genome Data Viewer
    Location:
    2 A3; 2 17.68 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25547944..25552242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25657932..25662230)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene lipocalin 15 Neighboring gene lipocalin 8 Neighboring gene lipocalin 6 Neighboring gene lipocalin 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. Zhang YR, et al. PLoS One, 2012. PMID 22574224, Free PMC Article
    2. Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis. Rankin TL, et al. Biol Reprod, 1992 May. PMID 1591332
    3. The 18-kDa mouse epididymal protein (MEP 10) binds retinoic acid. Rankin TL, et al. Biol Reprod, 1992 May. PMID 1591333
    4. Secretion and transport of mouse epididymal proteins after injection of 35S-methionine. Vreeburg JT, et al. Biol Reprod, 1990 Jul. PMID 2393684
    5. Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid. Lareyre JJ, et al. Endocrinology, 1998 Jun. PMID 9607808

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Forkhead box A2 restricts androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.
      Title: The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables retinoid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within retinoic acid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epididymal-specific lipocalin-5
    Names
    epididymal retinoic acid binding protein
    epididymal secretory protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042630.2 → NP_001036095.1  epididymal-specific lipocalin-5 isoform b precursor

      See identical proteins and their annotated locations for NP_001036095.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AK136629, AK162355
      Consensus CDS
      CCDS38078.1
      UniProtKB/Swiss-Prot
      A2AJB7
      Related
      ENSMUSP00000097888.4, ENSMUST00000100313.4
      Conserved Domains (2) summary
      pfam00061
      Location:41 → 179
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
      cl21528
      Location:31 → 48
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_001276257.1 → NP_001263186.1  epididymal-specific lipocalin-5 isoform c precursor

      See identical proteins and their annotated locations for NP_001263186.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) is the same length but has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK136629, AV379690
      Consensus CDS
      CCDS71003.1
      UniProtKB/Swiss-Prot
      A2AJB7
      Related
      ENSMUSP00000097887.4, ENSMUST00000100312.10
      Conserved Domains (2) summary
      pfam00061
      Location:41 → 179
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
      cl21528
      Location:31 → 48
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    3. NM_007947.3 → NP_031973.2  epididymal-specific lipocalin-5 isoform a precursor

      See identical proteins and their annotated locations for NP_031973.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform a.
      Source sequence(s)
      AK021014, AK136629, AV379690
      Consensus CDS
      CCDS38079.1
      UniProtKB/Swiss-Prot
      A2AJB7, O88787, Q3TS05, Q3UW42, Q9R2C6
      Related
      ENSMUSP00000028306.7, ENSMUST00000028306.13
      Conserved Domains (2) summary
      pfam00061
      Location:41 → 179
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
      cl21528
      Location:31 → 48
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25547944..25552242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497666.4 → XP_006497729.1  epididymal-specific lipocalin-5 isoform X2

      Conserved Domains (1) summary
      cl10502
      Location:31 → 189
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_006497665.1 → XP_006497728.1  epididymal-specific lipocalin-5 isoform X1

      Conserved Domains (1) summary
      cl10502
      Location:31 → 182
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. XM_006497669.1 → XP_006497732.1  epididymal-specific lipocalin-5 isoform X5

      Conserved Domains (1) summary
      cl10502
      Location:31 → 147
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    4. XM_006497668.2 → XP_006497731.1  epididymal-specific lipocalin-5 isoform X4

      See identical proteins and their annotated locations for XP_006497731.1

      Conserved Domains (1) summary
      cl10502
      Location:31 → 189
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    5. XM_006497667.3 → XP_006497730.1  epididymal-specific lipocalin-5 isoform X3

      See identical proteins and their annotated locations for XP_006497730.1

      Conserved Domains (1) summary
      cl10502
      Location:31 → 189
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AJB7.1 GenPept UniProtKB/Swiss-Prot:A2AJB7

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