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    Paep progestagen associated endometrial protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100169711, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Paepprovided by RGD
    Official Full Name
    progestagen associated endometrial proteinprovided by RGD
    Primary source
    RGD:2293817
    See related
    EnsemblRapid:ENSRNOG00000073207 AllianceGenome:RGD:2293817
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lcn11
    Summary
    Predicted to enable odorant binding activity. Predicted to be involved in several processes, including negative regulation of sperm capacitation; positive regulation of granulocyte macrophage colony-stimulating factor production; and regulation of binding activity of sperm to zona pellucida. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human PAEP (progestagen associated endometrial protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1.8), Uterus (RPKM 1.8) and 4 other tissues See more
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    Genomic context

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    Location:
    3p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28929252..28932592, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8531136..8534430, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2935396..2938883, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene brain expressed myelocytomatosis oncogene Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 5 Neighboring gene progestagen associated endometrial protein like 1 Neighboring gene lipocalin 3 Neighboring gene von Ebner gland protein 1-like Neighboring gene odorant binding protein 2B like 1 Neighboring gene odorant binding protein 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the oligomerization and ligand-binding properties of recombinant rat lipocalin 11. Gu Y, et al. Biochim Biophys Acta, 2013 Jan. PMID 23451353
    2. Glycodelin-A modulates cytokine production of peripheral blood natural killer cells. Lee CL, et al. Fertil Steril, 2010 Jul. PMID 19945098
    3. Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. Alok A, et al. Int J Biochem Cell Biol, 2009 May. PMID 18996219
    4. Cumulus oophorus-associated glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding. Chiu PC, et al. J Biol Chem, 2007 Feb 23. PMID 17192260
    5. Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa. Chiu PC, et al. J Biol Chem, 2005 Jul 8. PMID 15883155

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of granulocyte macrophage colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    progestagen associated endometrial protein
    Names
    lipocalin 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135809.1 → NP_001129281.1  progestagen associated endometrial protein precursor

      See identical proteins and their annotated locations for NP_001129281.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ537495
      UniProtKB/TrEMBL
      B3EY86
      Related
      ENSRNOP00000075567.1, ENSRNOT00000084196.3
      Conserved Domains (1) summary
      pfam00061
      Location:35 → 145
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28929252..28932592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282942.1 → XP_063139012.1  progestagen associated endometrial protein isoform X2

    2. XM_063282941.1 → XP_063139011.1  progestagen associated endometrial protein isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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