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    KRR1 KRR1 small subunit processome component homolog [ Homo sapiens (human) ]

    Gene ID: 11103, updated on 28-Oct-2024

    Summary

    Official Symbol
    KRR1provided by HGNC
    Official Full Name
    KRR1 small subunit processome component homologprovided by HGNC
    Primary source
    HGNC:HGNC:5176
    See related
    Ensembl:ENSG00000111615 MIM:612817; AllianceGenome:HGNC:5176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRB2; RIP-1
    Summary
    Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in chromosome; intercellular bridge; and nuclear lumen. Part of small-subunit processome. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in appendix (RPKM 20.3), bone marrow (RPKM 19.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KRR1 in Genome Data Viewer
    Location:
    12q21.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75490863..75511609, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75465553..75486296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75884643..75905389, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr12:75784671-75784843 Neighboring gene GLIPR1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75880921-75881422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75881423-75881922 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75904602-75905146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75905147-75905690 Neighboring gene GLI pathogenesis related 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:75916502-75917002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:75917003-75917503 Neighboring gene uncharacterized LOC105369844 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:76026122-76026705 Neighboring gene Sharpr-MPRA regulatory region 10558 Neighboring gene MPRA-validated peak1837 silencer Neighboring gene phosphogluconate dehydrogenase pseudogene 2 Neighboring gene uncharacterized LOC107984533

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev Information on HIV-1 rev binding protein 2 is the result of a direct sequence submission to NCBI. Interaction with HIV-1 Rev is assumed based on the name of the protein, however no publications describing this interaction have been identified PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human small subunit (SSU) processome component, homolog (KRR1) at amino acid residues 286-287 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    KRR1 small subunit processome component homolog
    Names
    HIV-1 Rev-binding protein 2
    HIV-1 rev binding protein 2
    KRR-R motif-containing protein 1
    KRR1, small subunit (SSU) processome component, homolog
    Rev interacting protein
    rev-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007043.7NP_008974.5  KRR1 small subunit processome component homolog

      See identical proteins and their annotated locations for NP_008974.5

      Status: VALIDATED

      Source sequence(s)
      AC121761, BC005225
      Consensus CDS
      CCDS9012.1
      UniProtKB/Swiss-Prot
      A0FIK6, A0JLP0, B2R989, E7EUQ0, Q13601, Q8NEA8, Q8TC37, Q96AT5
      Related
      ENSP00000229214.4, ENST00000229214.9
      Conserved Domains (2) summary
      smart00322
      Location:158208
      KH; K homology RNA-binding domain
      COG1094
      Location:56230
      Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      75490863..75511609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428133.1XP_047284089.1  KRR1 small subunit processome component homolog isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      75465553..75486296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)