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    Bcas2 BCAS2 pre-mRNA processing factor [ Mus musculus (house mouse) ]

    Gene ID: 68183, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bcas2provided by MGI
    Official Full Name
    BCAS2 pre-mRNA processing factorprovided by MGI
    Primary source
    MGI:MGI:1915433
    See related
    Ensembl:ENSMUSG00000005687 AllianceGenome:MGI:1915433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430539P16Rik
    Summary
    Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; ovarian follicle development; and spindle assembly. Part of Prp19 complex. Is expressed in several structures, including central nervous system; early conceptus; oocyte; peripheral nervous system ganglion; and submandibular gland primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 58.9), liver E14.5 (RPKM 49.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcas2 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.25 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103078971..103086479)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103171655..103179163)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08585 Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene STARR-seq mESC enhancer starr_08586 Neighboring gene DENN domain containing 2C Neighboring gene STARR-seq mESC enhancer starr_08590 Neighboring gene STARR-seq mESC enhancer starr_08592 Neighboring gene STARR-positive B cell enhancer mm9_chr3:102975364-102975665 Neighboring gene STARR-seq mESC enhancer starr_08594 Neighboring gene STARR-seq mESC enhancer starr_08595 Neighboring gene STARR-seq mESC enhancer starr_08596 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103010366-103010667 Neighboring gene STARR-seq mESC enhancer starr_08597 Neighboring gene predicted gene, 40113 Neighboring gene STARR-seq mESC enhancer starr_08598 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103082888-103083189 Neighboring gene tripartite motif-containing 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice. Chen X, et al. Endocrinology, 2023 Nov 20. PMID 37820033
    2. Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via β-catenin. Chen HH, et al. Stem Cell Res Ther, 2022 Apr 11. PMID 35410459, Free PMC Article
    3. Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin. Huang CW, et al. Sci Rep, 2016 Oct 7. PMID 27713508, Free PMC Article
    4. BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing. Yao X, et al. J Ovarian Res, 2023 May 29. PMID 37248466, Free PMC Article
    5. Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells. Lee S, et al. Cancer Lett, 2002 Dec 15. PMID 12406557

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing.
      Title: BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing.
    2. BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.
      Title: BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice.
    3. BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing.
      Title: BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing.
    4. Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via beta-catenin.
      Title: Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via β-catenin.
    5. BCAS2 is involved in alternative splicing and mouse oocyte development.
      Title: BCAS2 is involved in alternative splicing and mouse oocyte development.
    6. Study results suggest that Bcas2 regulates alternative splicing in spermatogonia and the transition to meiosis initiation, and male fertility.
      Title: BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.
    7. BCAS2 is an upstream regulator of beta-catenin gene expression and plays a role in dendrite growth at least partly through beta-catenin in the forebrain.
      Title: Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin.
    8. BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
      Title: BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
    9. Maternal BCAS2 protects genomic integrity in mouse early embryonic development.
      Title: Maternal BCAS2 protects genomic integrity in mouse early embryonic development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7712

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of DNA replication factor A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Prp19 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-splicing factor SPF27
    Names
    DNA amplified in mammary carcinoma 1 protein
    breast carcinoma amplified sequence 2
    breast carcinoma-amplified sequence 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356330.1 → NP_001343259.1  pre-mRNA-splicing factor SPF27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC150894
      UniProtKB/TrEMBL
      Q3U5M2
      Conserved Domains (1) summary
      pfam05700
      Location:11 → 197
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

    2. NM_001356331.1 → NP_001343260.1  pre-mRNA-splicing factor SPF27 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC150894
      UniProtKB/TrEMBL
      Q05CL7
      Conserved Domains (1) summary
      pfam05700
      Location:1 → 149
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

    3. NM_026602.4 → NP_080878.2  pre-mRNA-splicing factor SPF27 isoform 1

      See identical proteins and their annotated locations for NP_080878.2

      Status: VALIDATED

      Source sequence(s)
      AC150894
      Consensus CDS
      CCDS17691.1
      UniProtKB/Swiss-Prot
      Q3TKJ5, Q91YX8, Q9D287, Q9D2U4, Q9DAI0
      UniProtKB/TrEMBL
      Q3U5M2
      Related
      ENSMUSP00000005830.9, ENSMUST00000005830.15
      Conserved Domains (1) summary
      pfam05700
      Location:11 → 214
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      103078971..103086479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D287.1 GenPept UniProtKB/Swiss-Prot:Q9D287

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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