Bambi BMP and activin membrane-bound inhibitor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bambiprovided by RGD
Official Full Name: BMP and activin membrane-bound inhibitorprovided by RGD
Primary source: RGD:621831
See related: EnsemblRapid:ENSRNOG00000016066 AllianceGenome:RGD:621831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable frizzled binding activity. Involved in transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 227.8), Lung (RPKM 138.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (58816438..58821003, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (54121251..54125816, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (56905419..56909675, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of circDNMT3B contributes to vascular dysfunction in diabetic retinas through regulating miR-20b-5p and BAMBI, providing a potential treatment strategy for diabetic retinopathy
Title: Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI.
These findings indicate that LPS increases TGF-beta1 production through paracrine and autocrine mechanisms and that LPS enhances TGF-beta1 signalling in PSCs by repressing BAMBI via TLR4/MyD88/NF-kB activation.
Title: Lipopolysaccharide enhances TGF-β1 signalling pathway and rat pancreatic fibrosis.
BAMBI plays a neuroprotective role by decreasing inflammation and activating autophagy in rats with SCI.
Title: BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury.
Angiotensin II enhances lipopolysaccharide-TLR4 pathway signaling and further down-regulates expression of BAMBI through up-regulation of TLR4, which results in facilitation of pro-fibrotic activity of TGF-beta1.
Title: Angiotensin II facilitates fibrogenic effect of TGF-β1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II.
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/beta-catenin signaling
Title: Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.
Regulated Bambi mRNA synthesis may contribute to TGF beta superfamily signaling modulation in several organs, as suggested by its discrete expression switch in male germ cells.
Title: Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells.

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General gene information

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Markers

Bambi (e-PCR), detects polymorphism
- UniSTS:506747

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BMP and activin membrane-bound inhibitor homolog

Names: BMP and activin membrane-bound inhibitor, homolog; kinase-deficient TGFbeta superfamily receptor subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139082.3 → NP_620782.1 BMP and activin membrane-bound inhibitor homolog precursor

See identical proteins and their annotated locations for NP_620782.1

Status: PROVISIONAL

Source sequence(s)

AF387513

UniProtKB/Swiss-Prot

Q91XN4

UniProtKB/TrEMBL

A6K9G6

Related

ENSRNOP00000021801.3, ENSRNOT00000021801.7

Conserved Domains (1) summary

pfam06211
Location:4 → 111

BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

58816438..58821003 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096114.2 → XP_038952042.1 BMP and activin membrane-bound inhibitor homolog isoform X1

UniProtKB/TrEMBL

A0A8I6ABP7

Related

ENSRNOP00000090807.1, ENSRNOT00000105136.2

Conserved Domains (1) summary

pfam06211
Location:8 → 95

BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain