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Conserved domains on  [gi|1958723847|ref|XP_038952042|]
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BMP and activin membrane-bound inhibitor homolog isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAMBI_C pfam19337
BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the ...
 107-244 9.36e-96

BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the C-terminal domain of BMP and activin membrane-bound inhibitor homolog (BAMBI) which contains the transmembrane domain and a short intracellular domain that, unlike all other known TGF-beta type I or type II receptors, does not encode a serine/threonine-kinase domain. However, it shares sequence homology with the E6 and catalytic loops of receptor serine/threonine kinases. BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


:

Pssm-ID: 437169  Cd Length: 138  Bit Score: 276.44  E-value: 9.36e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847 107 QGNRYQHDSSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHH 186
Cdd:pfam19337   1 VGSRHQSDSNRNLITKVQELASAKEVWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLRDQRQQMLSRLHYSFHGHH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958723847 187 SKKGQVAKLDLECMVPVSGQENCCLTCDKMRQADLSNEKILSLVHWGMYSGHGKLEFV 244
Cdd:pfam19337  81 AKKGAVLKLDLECMVPVGGHENCCLTCDKTRPSDLSNDGILSLVHWGMYSGHGKLEFV 138
BAMBI super family cl05626
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of ...
 8-95 1.67e-50

BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


The actual alignment was detected with superfamily member pfam06211:

Pssm-ID: 283793  Cd Length: 107  Bit Score: 160.52  E-value: 1.67e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847   8 SQSEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNTNSPLTHGCLDSLASTADICRAKQAQNHSGPTMPtLECCHEDM 87
Cdd:pfam06211  21 TKGEIRCYCDAPHCVATGYMCKSELNACFTRLLDPQNTNSPLTHGCLDSLLNSGDICHSKQAFDHSGGSAP-LECCHEDM 99


                  ....*...
gi 1958723847  88 CNYRGLHD 95
Cdd:pfam06211 100 CNYRGLHD 107
 
Name Accession Description Interval E-value
BAMBI_C pfam19337
BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the ...
 107-244 9.36e-96

BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the C-terminal domain of BMP and activin membrane-bound inhibitor homolog (BAMBI) which contains the transmembrane domain and a short intracellular domain that, unlike all other known TGF-beta type I or type II receptors, does not encode a serine/threonine-kinase domain. However, it shares sequence homology with the E6 and catalytic loops of receptor serine/threonine kinases. BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 437169  Cd Length: 138  Bit Score: 276.44  E-value: 9.36e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847 107 QGNRYQHDSSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHH 186
Cdd:pfam19337   1 VGSRHQSDSNRNLITKVQELASAKEVWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLRDQRQQMLSRLHYSFHGHH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958723847 187 SKKGQVAKLDLECMVPVSGQENCCLTCDKMRQADLSNEKILSLVHWGMYSGHGKLEFV 244
Cdd:pfam19337  81 AKKGAVLKLDLECMVPVGGHENCCLTCDKTRPSDLSNDGILSLVHWGMYSGHGKLEFV 138
BAMBI pfam06211
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of ...
 8-95 1.67e-50

BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 283793  Cd Length: 107  Bit Score: 160.52  E-value: 1.67e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847   8 SQSEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNTNSPLTHGCLDSLASTADICRAKQAQNHSGPTMPtLECCHEDM 87
Cdd:pfam06211  21 TKGEIRCYCDAPHCVATGYMCKSELNACFTRLLDPQNTNSPLTHGCLDSLLNSGDICHSKQAFDHSGGSAP-LECCHEDM 99


                  ....*...
gi 1958723847  88 CNYRGLHD 95
Cdd:pfam06211 100 CNYRGLHD 107
TFP_LU_ECD_BAMBI cd23576
extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and ...
 11-90 1.16e-32

extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and similar proteins; BAMBI (also called non-metastatic gene A protein (NMA), or putative transmembrane protein NMA) is a transmembrane protein that acts as an important regulator of trabecular meshwork extracellular matrix and ocular hypertension. It negatively regulates the signaling activity of transforming growth factor (TGF)-beta, activin, and bone morphogenetic protein (BMP). BAMBI can function as a positive regulator of the Wnt/beta-catenin pathway to promote cell proliferation. It may be a reactive oxygen regulator to affect adipogenesis, thereby controlling obesity and metabolic syndrome. BAMBI contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467106  Cd Length: 80  Bit Score: 114.08  E-value: 1.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847  11 EIRCYCDAAHCVATGYMCKSELsACFSRLLDPQNTNSPLTHGCLDSLASTADICRAKQAQNHS-GPTMPTLECCHEDMCN 89
Cdd:cd23576     1 EIRCYCNLPECVSTGYMCKSRG-GCFSELVDSSNTSSRSTHGCLESLPNKPELCEEKLESNKKtSSKVPLLLCCKEDMCN 79


                  .
gi 1958723847  90 Y 90
Cdd:cd23576    80 Y 80
 
Name Accession Description Interval E-value
BAMBI_C pfam19337
BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the ...
 107-244 9.36e-96

BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the C-terminal domain of BMP and activin membrane-bound inhibitor homolog (BAMBI) which contains the transmembrane domain and a short intracellular domain that, unlike all other known TGF-beta type I or type II receptors, does not encode a serine/threonine-kinase domain. However, it shares sequence homology with the E6 and catalytic loops of receptor serine/threonine kinases. BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 437169  Cd Length: 138  Bit Score: 276.44  E-value: 9.36e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847 107 QGNRYQHDSSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHH 186
Cdd:pfam19337   1 VGSRHQSDSNRNLITKVQELASAKEVWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLRDQRQQMLSRLHYSFHGHH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958723847 187 SKKGQVAKLDLECMVPVSGQENCCLTCDKMRQADLSNEKILSLVHWGMYSGHGKLEFV 244
Cdd:pfam19337  81 AKKGAVLKLDLECMVPVGGHENCCLTCDKTRPSDLSNDGILSLVHWGMYSGHGKLEFV 138
BAMBI pfam06211
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of ...
 8-95 1.67e-50

BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 283793  Cd Length: 107  Bit Score: 160.52  E-value: 1.67e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847   8 SQSEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNTNSPLTHGCLDSLASTADICRAKQAQNHSGPTMPtLECCHEDM 87
Cdd:pfam06211  21 TKGEIRCYCDAPHCVATGYMCKSELNACFTRLLDPQNTNSPLTHGCLDSLLNSGDICHSKQAFDHSGGSAP-LECCHEDM 99


                  ....*...
gi 1958723847  88 CNYRGLHD 95
Cdd:pfam06211 100 CNYRGLHD 107
TFP_LU_ECD_BAMBI cd23576
extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and ...
 11-90 1.16e-32

extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and similar proteins; BAMBI (also called non-metastatic gene A protein (NMA), or putative transmembrane protein NMA) is a transmembrane protein that acts as an important regulator of trabecular meshwork extracellular matrix and ocular hypertension. It negatively regulates the signaling activity of transforming growth factor (TGF)-beta, activin, and bone morphogenetic protein (BMP). BAMBI can function as a positive regulator of the Wnt/beta-catenin pathway to promote cell proliferation. It may be a reactive oxygen regulator to affect adipogenesis, thereby controlling obesity and metabolic syndrome. BAMBI contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467106  Cd Length: 80  Bit Score: 114.08  E-value: 1.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958723847  11 EIRCYCDAAHCVATGYMCKSELsACFSRLLDPQNTNSPLTHGCLDSLASTADICRAKQAQNHS-GPTMPTLECCHEDMCN 89
Cdd:cd23576     1 EIRCYCNLPECVSTGYMCKSRG-GCFSELVDSSNTSSRSTHGCLESLPNKPELCEEKLESNKKtSSKVPLLLCCKEDMCN 79


                  .
gi 1958723847  90 Y 90
Cdd:cd23576    80 Y 80
TFP_LU_ECD_ALK2 cd23535
extracellular domain (ECD) found in activin receptor-like kinase 2 (ALK-2) and similar ...
 12-89 6.35e-05

extracellular domain (ECD) found in activin receptor-like kinase 2 (ALK-2) and similar proteins; ALK-2 (EC 2.7.11.30, also called ACVRLK2, or activin receptor type-1 (ACVR1), or activin receptor type I (ACTR-I), or serine/threonine-protein kinase receptor R1 (SKR1), or TGF-B superfamily receptor type I (TSR-I)) is bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, ALK-2 forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A, or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, ALK-2 suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, it can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. This model corresponds to the extracellular domain (ECD) of ALK-2, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467065  Cd Length: 71  Bit Score: 40.06  E-value: 6.35e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958723847  12 IRCYCDAAHCVATGYmCKSElsACFSRLlDPQNTNSPLTHGCLDSLASTADICRAKQAQNHSgptmptLECCHEDMCN 89
Cdd:cd23535     1 FECVCEGSSCPGGDR-CEGQ--QCFSSL-SVEDGGAVVQKGCLEGEEQGRMTCKTPPSPDLA------VECCSGHLCN 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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