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    Mtarc2 mitochondrial amidoxime reducing component 2 [ Mus musculus (house mouse) ]

    Gene ID: 67247, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Mtarc2provided by MGI
    Official Full Name
    mitochondrial amidoxime reducing component 2provided by MGI
    Primary source
    MGI:MGI:1914497
    See related
    Ensembl:ENSMUSG00000073481 AllianceGenome:MGI:1914497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Marc2; Mosc2; mARC1; 2810484M10Rik
    Summary
    Predicted to enable molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Predicted to be involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Is expressed in cerebral cortex ventricular layer. Orthologous to human MTARC2 (mitochondrial amidoxime reducing component 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 313.8), small intestine adult (RPKM 139.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtarc2 in Genome Data Viewer
    Location:
    1 H5; 1 89.12 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184545263..184579266, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (184813066..184846451, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51725 Neighboring gene mitochondrial amidoxime reducing component 1 Neighboring gene microRNA 1981 Neighboring gene STARR-positive B cell enhancer ABC_E10073 Neighboring gene STARR-seq mESC enhancer starr_03314 Neighboring gene STARR-positive B cell enhancer ABC_E11112 Neighboring gene predicted gene, 34451 Neighboring gene RIKEN cDNA C130074G19 gene Neighboring gene predicted gene, 34602 Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial amidoxime-reducing component 2 (MARC2) has a significant role in N-reductive activity and energy metabolism. Rixen S, et al. J Biol Chem, 2019 Nov 15. PMID 31554661, Free PMC Article
    2. Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. Smagris E, et al. PLoS Genet, 2024 Mar. PMID 38437227, Free PMC Article
    3. Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria. Neve EP, et al. J Biol Chem, 2012 Feb 24. PMID 22203676, Free PMC Article
    4. The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice. Jakobs HH, et al. PLoS One, 2014. PMID 25144769, Free PMC Article
    5. Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes. Wahl B, et al. J Biol Chem, 2010 Nov 26. PMID 20861021, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Striking phenotypical features of MARC2 Knockout Mice mice were lower body weight, increased body temperature, decreased levels of total cholesterol, and increased glucose levels, supporting previous findings that MARC2 affects energy pathways.
      Title: Mitochondrial amidoxime-reducing component 2 (MARC2) has a significant role in N-reductive activity and energy metabolism.
    2. The presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a third unknown component (a CYB5B reductase).
      Title: Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molybdenum ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molybdopterin cofactor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nitrate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nitrate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nitrite reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrite reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of nitrogen compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular detoxification of nitrogen compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nitrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial amidoxime reducing component 2
    Names
    MOCO sulphurase C-terminal domain containing 2
    MOSC domain-containing protein 2, mitochondrial
    moco sulfurase C-terminal domain-containing protein 2
    molybdenum cofactor sulfurase C-terminal domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368285.1 → NP_001355214.1  mitochondrial amidoxime reducing component 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131992

    2. NM_001368286.1 → NP_001355215.1  mitochondrial amidoxime reducing component 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131992
      Conserved Domains (1) summary
      COG3217
      Location:1 → 240
      YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]

    3. NM_133684.4 → NP_598445.1  mitochondrial amidoxime reducing component 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_598445.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC131992
      Consensus CDS
      CCDS15594.1
      UniProtKB/Swiss-Prot
      Q922Q1
      Related
      ENSMUSP00000066715.4, ENSMUST00000068725.10
      Conserved Domains (3) summary
      COG3217
      Location:56 → 333
      YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
      pfam03473
      Location:202 → 334
      MOSC; MOSC domain
      pfam03476
      Location:54 → 175
      MOSC_N; MOSC N-terminal beta barrel domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      184545263..184579266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153109.1 → XP_036009002.1  mitochondrial amidoxime reducing component 2 isoform X1

      Conserved Domains (1) summary
      COG3217
      Location:1 → 240
      YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922Q1.1 GenPept UniProtKB/Swiss-Prot:Q922Q1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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