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    ZNG1F Zn regulated GTPase metalloprotein activator 1F [ Homo sapiens (human) ]

    Gene ID: 644019, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNG1Fprovided by HGNC
    Official Full Name
    Zn regulated GTPase metalloprotein activator 1Fprovided by HGNC
    Primary source
    HGNC:HGNC:31978
    See related
    Ensembl:ENSG00000215126 AllianceGenome:HGNC:31978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBWD6; CBWD7
    Summary
    Predicted to enable GTP binding activity; hydrolase activity; and metal ion binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Ubiquitous expression in kidney (RPKM 11.5), thyroid (RPKM 10.9) and 25 other tissues See more
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    Genomic context

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    See ZNG1F in Genome Data Viewer
    Location:
    9p11.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (41131309..41205735, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (42096131..42163687)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (69204538..69262546, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:69179459-69180234 Neighboring gene long intergenic non-protein coding RNA 3025 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:69180235-69181009 Neighboring gene forkhead box D4 like 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:69261657-69262230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:69262231-69262802 Neighboring gene protein FRG1B-like Neighboring gene microRNA 4477a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Weiss A, et al. Cell, 2022 Jun 9. PMID 35584702, Free PMC Article
    2. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
    3. CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment. Smits DJ, et al. Hum Genet, 2023 Mar. PMID 36538041, Free PMC Article
    4. Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion. Seo HG, et al. Cell Death Dis, 2020 Sep 29. PMID 32994395, Free PMC Article
    5. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40320, FLJ60409, DKFZp686L07117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc-regulated GTPase metalloprotein activator 1F
    Names
    COBW domain containing 6
    COBW domain containing 7
    COBW domain-containing protein 6
    cobalamin synthase W domain-containing protein 6
    cobalamin synthetase W domain-containing protein 6
    putative COBW domain-containing protein 7
    putative cobalamin synthase W domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085457.2 → NP_001078926.1  zinc-regulated GTPase metalloprotein activator 1F isoform 1

      See identical proteins and their annotated locations for NP_001078926.1

      Status: VALIDATED

      Source sequence(s)
      BX255923
      Consensus CDS
      CCDS43827.1
      UniProtKB/Swiss-Prot
      Q4V339
      UniProtKB/TrEMBL
      A0A0A0MRU4
      Related
      ENSP00000366608.4, ENST00000377391.8
      Conserved Domains (3) summary
      COG0523
      Location:42 → 376
      YejR; GTPase, G3E family [General function prediction only]
      pfam07683
      Location:274 → 373
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain
      cl21455
      Location:43 → 207
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001386876.1 → NP_001373805.1  zinc-regulated GTPase metalloprotein activator 1F isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX255923
      UniProtKB/TrEMBL
      A0A0A0MRU4
      Conserved Domains (3) summary
      COG3044
      Location:19 → 62
      COG3044; Predicted ATPase of the ABC class [General function prediction only]
      cd03112
      Location:43 → 226
      CobW-like; cobalamin synthesis protein CobW
      pfam07683
      Location:254 → 353
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain

    3. NM_001386877.1 → NP_001373806.1  zinc-regulated GTPase metalloprotein activator 1F isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX255923
      UniProtKB/TrEMBL
      A0A087WWG3
      Conserved Domains (2) summary
      COG0523
      Location:42 → 327
      YejR; GTPase, G3E family [General function prediction only]
      COG3044
      Location:19 → 62
      COG3044; Predicted ATPase of the ABC class [General function prediction only]

    RNA

    1. NR_170339.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX255923
      Related
      ENST00000494538.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      41131309..41205735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015028.2 → XP_016870517.1  zinc-regulated GTPase metalloprotein activator 1F isoform X10

    2. XM_047423722.1 → XP_047279678.1  zinc-regulated GTPase metalloprotein activator 1F isoform X10

    3. XM_047423720.1 → XP_047279676.1  zinc-regulated GTPase metalloprotein activator 1F isoform X6

    4. XM_017015025.2 → XP_016870514.1  zinc-regulated GTPase metalloprotein activator 1F isoform X5

      UniProtKB/TrEMBL
      A0A087WWG3

    5. XM_017015022.2 → XP_016870511.1  zinc-regulated GTPase metalloprotein activator 1F isoform X3

      UniProtKB/TrEMBL
      A0A087WWG3

    6. XM_017015023.2 → XP_016870512.1  zinc-regulated GTPase metalloprotein activator 1F isoform X4

      UniProtKB/TrEMBL
      A0A0A0MRU4

    7. XM_017015021.2 → XP_016870510.1  zinc-regulated GTPase metalloprotein activator 1F isoform X2

      UniProtKB/TrEMBL
      A0A0A0MRU4

    8. XM_047423721.1 → XP_047279677.1  zinc-regulated GTPase metalloprotein activator 1F isoform X8

    9. XM_017015026.2 → XP_016870515.1  zinc-regulated GTPase metalloprotein activator 1F isoform X7

    10. XM_017015019.2 → XP_016870508.1  zinc-regulated GTPase metalloprotein activator 1F isoform X1

      UniProtKB/TrEMBL
      A0A0A0MRU4

    11. XM_017015036.2 → XP_016870525.1  zinc-regulated GTPase metalloprotein activator 1F isoform X20

      UniProtKB/TrEMBL
      A0A087WWG3

    12. XM_024447653.2 → XP_024303421.1  zinc-regulated GTPase metalloprotein activator 1F isoform X19

      UniProtKB/TrEMBL
      A0A087WWG3
      Conserved Domains (2) summary
      COG0523
      Location:42 → 347
      YejR; GTPase, G3E family [General function prediction only]
      cl26601
      Location:19 → 62
      ABC_ATPase; Predicted ATPase of the ABC class

    13. XM_017015035.2 → XP_016870524.1  zinc-regulated GTPase metalloprotein activator 1F isoform X18

      UniProtKB/TrEMBL
      A0A0A0MRU4, H0Y5V3
      Related
      ENSP00000401079.2, ENST00000456520.5

    14. XM_047423723.1 → XP_047279679.1  zinc-regulated GTPase metalloprotein activator 1F isoform X15

    15. XM_017015029.3 → XP_016870518.1  zinc-regulated GTPase metalloprotein activator 1F isoform X11

    16. XM_017015034.1 → XP_016870523.1  zinc-regulated GTPase metalloprotein activator 1F isoform X17

      UniProtKB/TrEMBL
      Q9HAZ6

    17. XM_017015033.1 → XP_016870522.1  zinc-regulated GTPase metalloprotein activator 1F isoform X16

    18. XM_024447652.1 → XP_024303420.1  zinc-regulated GTPase metalloprotein activator 1F isoform X14

      Conserved Domains (1) summary
      cl26870
      Location:20 → 208
      CobW_C; Cobalamin synthesis protein cobW C-terminal domain

    19. XM_017015031.1 → XP_016870520.1  zinc-regulated GTPase metalloprotein activator 1F isoform X13

    20. XM_017015030.2 → XP_016870519.1  zinc-regulated GTPase metalloprotein activator 1F isoform X12

    21. XM_017015027.2 → XP_016870516.1  zinc-regulated GTPase metalloprotein activator 1F isoform X9

    RNA

    1. XR_001746362.2 RNA Sequence

    2. XR_001746359.2 RNA Sequence

    3. XR_007061337.1 RNA Sequence

    4. XR_001746361.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      42096131..42163687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363532.1 → XP_054219507.1  zinc-regulated GTPase metalloprotein activator 1F isoform X10

    2. XM_054363539.1 → XP_054219514.1  zinc-regulated GTPase metalloprotein activator 1F isoform X18

      UniProtKB/TrEMBL
      H0Y5V3

    3. XM_054363540.1 → XP_054219515.1  zinc-regulated GTPase metalloprotein activator 1F isoform X19

    4. XM_054363541.1 → XP_054219516.1  zinc-regulated GTPase metalloprotein activator 1F isoform X20

    5. XM_054363522.1 → XP_054219497.1  zinc-regulated GTPase metalloprotein activator 1F isoform X1

    6. XM_054363529.1 → XP_054219504.1  zinc-regulated GTPase metalloprotein activator 1F isoform X7

    7. XM_054363523.1 → XP_054219498.1  zinc-regulated GTPase metalloprotein activator 1F isoform X2

    8. XM_054363525.1 → XP_054219500.1  zinc-regulated GTPase metalloprotein activator 1F isoform X4

    9. XM_054363524.1 → XP_054219499.1  zinc-regulated GTPase metalloprotein activator 1F isoform X3

    10. XM_054363526.1 → XP_054219501.1  zinc-regulated GTPase metalloprotein activator 1F isoform X5

    11. XM_054363527.1 → XP_054219502.1  zinc-regulated GTPase metalloprotein activator 1F isoform X6

    12. XM_054363528.1 → XP_054219503.1  zinc-regulated GTPase metalloprotein activator 1F isoform X21

    13. XM_054363531.1 → XP_054219506.1  zinc-regulated GTPase metalloprotein activator 1F isoform X9

    14. XM_054363530.1 → XP_054219505.1  zinc-regulated GTPase metalloprotein activator 1F isoform X9

    15. XM_054363536.1 → XP_054219511.1  zinc-regulated GTPase metalloprotein activator 1F isoform X15

    16. XM_054363533.1 → XP_054219508.1  zinc-regulated GTPase metalloprotein activator 1F isoform X11

    17. XM_054363538.1 → XP_054219513.1  zinc-regulated GTPase metalloprotein activator 1F isoform X17

    18. XM_054363534.1 → XP_054219509.1  zinc-regulated GTPase metalloprotein activator 1F isoform X13

    19. XM_054363535.1 → XP_054219510.1  zinc-regulated GTPase metalloprotein activator 1F isoform X14

    20. XM_054363537.1 → XP_054219512.1  zinc-regulated GTPase metalloprotein activator 1F isoform X16

    RNA

    1. XR_008488057.1 RNA Sequence

    2. XR_008488056.1 RNA Sequence

    3. XR_008488055.1 RNA Sequence

    4. XR_008488058.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V339.1 GenPept UniProtKB/Swiss-Prot:Q4V339

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