1NIJ


Conserved Protein Domain Family
CobW_C
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pfam07683: CobW_C (this model, PSSM-Id:284986 is obsolete and has been replaced by 462228)
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Cobalamin synthesis protein cobW C-terminal domain
This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.
Links
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Statistics
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PSSM-Id: 284986
Aligned: 159 rows
Threshold Bit Score: 36.0626
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1NIJ_A       224 ISSIVVELDYPVDISEVSRVMENl--lLesADKLLRYKGMLWIDGE-PN-RLLFQGVQRLYSADw-DRPWG-DEKPHSTM 297 Escherichia col...
Q89DY4       214 FETLSWTSDHPISLPRLQQAIGR----L--APKLARAKGLFETVEQpGR-LTVFQFAGGRATLApgEAPTPg--VPRSRI 284 Bradyrhizobium ...
Q7NER1       257 FTSISLVSERPLAAKQFEQFLKD----L--PQGVFRGKGILWLAES-PE-KVIFHLVGSRIRID--RETWDg--ARKNQA 324 Gloeobacter vio...
Q3M246       264 FVSISFESDRPFDVYKFENFLTEe---M--PQEVFRAKGILWFSDS-EL-RHVFQLSGFRYSLN--ADEWQt--PPKNQA 332 Anabaena variab...
Q2JJ86       226 IQSVSFQLQQPLDLAAFRDWLQD----M--PETLFRAKGVLWVVDE-PQ-RVIFHQVGQRQTLFl-ERDWDpEEPRLSKI 296 Synechococcus s...
Q5FRQ7       227 FVSLEWRREFPLDLTGFRAVIER----H--APVLLRAKGILYLATApKR-ALLLQMTGSRITIGraPEKARs--DPDTRL 297 Gluconobacter o...
WP_012370617 224 FTALTITEPVPLHRQRFGAVLREileaY--AEDLYRYKGILHFSDT-DR-KTILQGTGMIYGTAt-RGEFEg--PKQTTL 296 Exiguobacterium...
WP_010874356 281 FTSLSFRSEQPFSIRKFQYFLDNq---L--TPNIFRAKGILWFNES-PK-RHIFHLSGKRFSLE--DDQWKg--EKSNQL 349 Synechocystis s...
WP_011924530 215 FATITWTSKAPLSLDRFQQVIGK----L--APRTLRIKGILLFTEH-PAqPILFQSVATRGTLApsPVPPAd--GLTAQL 285 Bradyrhizobium ...
WP_011957815 247 FSSWSYVNHRPFALKKLRTVLQD----L--PETIFRAKGIIYLAET-PGrRAILQIVGVRITVSv-GEPWGd-TPPGTQM 317 Roseiflexus sp....

1NIJ_A       298 VFIGI--QLPEEEIRAAFAGLR 317 Escherichia coli K-12
Q89DY4       285 VFIAElgVLSKAELDGILAECV 306 Bradyrhizobium japonicum
Q7NER1       325 VFIGK--DFDREALKARWSECL 344 Gloeobacter violaceus
Q3M246       333 VFIGR--KLDMSQIYSKLNECL 352 Anabaena variabilis ATCC 29413
Q2JJ86       297 VLIGK--GLEPEQLAAGLSRVC 316 Synechococcus sp. JA-2-3B'a(2-13)
Q5FRQ7       298 VFIGRkgMFDPQALKDDLDAMR 319 Gluconobacter oxydans
WP_012370617 297 VFIGK--NLDEQAIRKGVKAAR 316 Exiguobacterium sibiricum
WP_010874356 350 VLIGQ--DLDHDKIREQLNHCL 369 Synechocystis sp. PCC 6803
WP_011924530 286 VLIGRegELDADQIDALLRGVI 307 Bradyrhizobium sp. ORS 278
WP_011957815 318 VFLGIpgGLNGDALQKAFDSCL 339 Roseiflexus sp. RS-1
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