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    CD4 CD4 molecule [ Ovis aries (sheep) ]

    Gene ID: 443509, updated on 5-Mar-2024

    Summary

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    Gene symbol
    CD4
    Gene description
    CD4 molecule
    See related
    EnsemblRapid:ENSOARG00020004460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See CD4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (209470950..209494966, complement)

    Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene lymphocyte activating 3 Neighboring gene parathymosin Neighboring gene myeloid leukemia factor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two allelic forms of ovine CD4 exhibiting a Ser183/Pro183 polymorphism in the coding sequence of domain 3. Boscariol R, et al. Vet Immunol Immunopathol, 2006 Oct 15. PMID 16879874
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in interleukin-15-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD4
    Names
    CD4 antigen
    T-cell surface antigen T4/Leu-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129902.1 → NP_001123374.1  T-cell surface glycoprotein CD4 precursor

      See identical proteins and their annotated locations for NP_001123374.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ407520
      UniProtKB/TrEMBL
      A0A6P3CX46, A0A6P7DSB8, Q19VJ6, W5P8J5
      Conserved Domains (4) summary
      pfam05790
      Location:314 → 387
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:208 → 313
      CD4-extracel; CD4, extracellular
      cd00096
      Location:209 → 214
      Ig; Ig strand A [structural motif]
      cl11960
      Location:26 → 122
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      209470950..209494966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042245234.1 → XP_042101168.1  T-cell surface glycoprotein CD4 isoform X2

      UniProtKB/TrEMBL
      W5P8J5
      Conserved Domains (1) summary
      smart00409
      Location:75 → 148
      IG; Immunoglobulin

    2. XM_027965769.2 → XP_027821570.1  T-cell surface glycoprotein CD4 isoform X1

      UniProtKB/TrEMBL
      A0A6P3CX46, A0A6P7DSB8, Q19VJ6, W5P8J5
      Related
      ENSOARP00020005644.1, ENSOART00020006836.2
      Conserved Domains (4) summary
      pfam05790
      Location:314 → 387
      C2-set; Immunoglobulin C2-set domain
      pfam09191
      Location:208 → 313
      CD4-extracel; CD4, extracellular
      cd00096
      Location:209 → 214
      Ig; Ig strand A [structural motif]
      cl11960
      Location:26 → 122
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05542.1 GenPept UniProtKB/Swiss-Prot:P05542

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials