1CID


Conserved Protein Domain Family
CD4-extracel
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pfam09191: CD4-extracel (this model, PSSM-Id:401221 is obsolete and has been replaced by 462712)
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CD4, extracellular
Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens.
Links
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Statistics
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PSSM-Id: 401221
Aligned: 20 rows
Threshold Bit Score: 137.437
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1CID_A         2 SITAYKSEGESAEFSFPLNLGEESL-----QGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQlSETLPLTLQI 76  Norway rat
XP_013000578 222 PNPFYKKEKESLEMCFPLTFNNEDLp---fTGELIWRADKASSSHSWITFSVANQRVSVQNDNQDPKLQmAEKTPLCLTL 298 domestic guinea...
EHB18620     195 PRTAYKKEGEALELSFPLTFDDEAH-----LGELSWRADRASSSQVWISFSVENRKVSVQMAALDPQLQmAEKTPLRLIL 269 naked mole-rat
EGV98537     209 STIVYKKEGEPAEFSFPLTFQDENL-----QGELMWRAEKASSPGPWVTFSLENKKVAVLKSWGTAKLQmKEELPLHLKI 283 Chinese hamster
NP_001295909 216 SQTIYGMTGKTVQFSFPLNLNEQELnkenpKGEFTWQVEGVASPQQPAKYSWKDNNLTPKNGIPNFKAE-KSNFAITFTL 294 Tasmanian devil
P06332       212 AITAYKSEGESAEFSFPLNFAEENG-----WGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQlKETLPLTLKI 286 house mouse
XP_023404487 168 STTIYKKDGEQVKFSFPLTFKDKDL-----TGELKWQAEGASSPKTWITFSLNNKKVSTSYIQK--RLQmSEALPLSFTL 240 African savanna...
XP_004092195 208 SSTVYKKEGEQVEFSFPLAFTVEKLt---gSGELCWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQmDKKLPLHLTL 284 northern white-...
XP_005338429 206 LNTVYKKVGEQVELSFPLNIGDEDL-----RGELKWQAERSSSSKTWFTFSLKNKQFSVQKVIQDPKLQvAENLPLRFTL 280 thirteen-lined ...
XP_023372849 129 SSAIYKKEGEQVEFSFPLTFKEERL-----EGELRWQAEKASSSKPWVTFFLENNKVSVKWITQDPKLQmEETLPLRFTL 203 small-eared galago

1CID_A        77 PQVSLQFAGSGNLTLTLDR--G-ILYQEVNLVV 106 Norway rat
XP_013000578 299 SSVLLQHAGSGNLTLTLDG--GqRLSQEVKLVV 329 domestic guinea pig
EHB18620     270 SEALLQHAGSGNLTLTLAG--DlKLHQEVNLVV 300 naked mole-rat
EGV98537     284 HQVSLDNAGSGNLTLTLAK--G-KLRQEVNLVV 313 Chinese hamster
NP_001295909 295 SPVLPQHAGSGVFLLKFSS--G-DLKQKVKLVV 324 Tasmanian devil
P06332       287 PQVSLQFAGSGNLTLTLDK--G-TLHQEVNLVV 316 house mouse
XP_023404487 241 PQALPQYAGFGNLTLDLAE--G-KLHQKVSLVV 270 African savanna elephant
XP_004092195 285 PQALPQYAGSGNLTLDLEAktG-KLRQEVNLVV 316 northern white-cheeked gibbon
XP_005338429 281 SHALPQYAGSGELTLTLDK--G-KLQKNVKLVL 310 thirteen-lined ground squirrel
XP_023372849 204 PQALPQYAGSGNLTLVITS--R-KLQQEVKLVV 233 small-eared galago
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