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    CDH5 cadherin 5 [ Sus scrofa (pig) ]

    Gene ID: 414737, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CDH5provided by VGNC
    Official Full Name
    cadherin 5provided by VGNC
    Primary source
    VGNC:VGNC:86486
    See related
    Ensembl:ENSSSCG00000035772
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    Cadherin-5
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Broad expression in lung (RPKM 153.2), subcutaneous adipose (RPKM 54.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See CDH5 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (27108560..27142145)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110261271 Neighboring gene uncharacterized LOC102162742 Neighboring gene ferritin light chain pseudogene Neighboring gene uncharacterized LOC110260931 Neighboring gene uncharacterized LOC110260929 Neighboring gene brain expressed associated with NEDD4 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_010448.4 Chromosome 6 Reference Sscrofa11.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Expressions of eNOS3 and Ve-cadherin in microvascular endothelium at 7-day of reperfused acute myocardial infarction. Kang S, et al. Cardiovasc Hematol Disord Drug Targets, 2009 Jun. PMID 19519369
    2. Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel. Zhao JL, et al. Vasa, 2007 Aug. PMID 18019273
    3. Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells. Hirano M, et al. Biochem Biophys Res Commun, 1999 Jan 19. PMID 9918866
    4. Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1: role in protection from complement-mediated injury. Dalmasso AP, et al. J Biol Chem, 2014 Jan 10. PMID 24280217, Free PMC Article
    5. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Gavard J, et al. Nat Cell Biol, 2006 Nov. PMID 17060906

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasculature development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-5
    Names
    VE cadherin
    cadherin 5, type 2 (vascular endothelium)
    vascular endothelial cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001649.2 → NP_001001649.2  cadherin-5 precursor

      See identical proteins and their annotated locations for NP_001001649.2

      Status: PROVISIONAL

      Source sequence(s)
      Y13919
      UniProtKB/Swiss-Prot
      O02840
      UniProtKB/TrEMBL
      A0A8D1XNS4, B4YYE0
      Related
      ENSSSCP00000047033.1, ENSSSCT00000065677.3
      Conserved Domains (3) summary
      cd11304
      Location:260 → 366
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:78 → 146
      CA; Cadherin repeats
      pfam01049
      Location:632 → 773
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      27108560..27142145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02840.1 GenPept UniProtKB/Swiss-Prot:O02840

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials