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    Mrgpre MAS related GPR family member E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 404660, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Mrgpreprovided by RGD
    Official Full Name
    MAS related GPR family member Eprovided by RGD
    Primary source
    RGD:738045
    See related
    EnsemblRapid:ENSRNOG00000065330 AllianceGenome:RGD:738045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mgrf; MrgE
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human MRGPRE (MAS related GPR family member E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 29.1), Muscle (RPKM 2.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrgpre in Genome Data Viewer
    Location:
    1q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208393141..208401252, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198963786..198969862, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216969464..216973936, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member G like 1 Neighboring gene MAS related GPR family member G Neighboring gene NAD synthetase 1 Neighboring gene 7-dehydrocholesterol reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD. Milasta S, et al. Mol Pharmacol, 2006 Feb. PMID 16282220
    2. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12909716, Free PMC Article
    3. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. Premzl M. Gene, 2014 Apr 25. PMID 24583173
    4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactions between rMrgD and rMrgE modulate the function of rMrgD.
      Title: Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member E
    Names
    MAS-related G-protein coupled receptor, member E
    MAS-related GPR, member E
    MAS-related gene E
    Mas-related G protein-coupled receptor f

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002288.2 → NP_001002288.1  mas-related G-protein coupled receptor member E

      See identical proteins and their annotated locations for NP_001002288.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q7TN40
      UniProtKB/TrEMBL
      W8W3M5
      Related
      ENSRNOP00000079771.1, ENSRNOT00000109796.2
      Conserved Domains (2) summary
      cd14964
      Location:53 → 79
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:42 → 291
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208393141..208401252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760163.4 → XP_008758385.1  mas-related G-protein coupled receptor member E isoform X1

      See identical proteins and their annotated locations for XP_008758385.1

      UniProtKB/Swiss-Prot
      Q7TN40
      UniProtKB/TrEMBL
      W8W3M5
      Related
      ENSRNOP00000089804.1, ENSRNOT00000115771.2
      Conserved Domains (2) summary
      cd14964
      Location:53 → 79
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:42 → 291
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006230870.5 → XP_006230932.1  mas-related G-protein coupled receptor member E isoform X1

      See identical proteins and their annotated locations for XP_006230932.1

      UniProtKB/Swiss-Prot
      Q7TN40
      UniProtKB/TrEMBL
      W8W3M5
      Related
      ENSRNOP00000106586.1, ENSRNOT00000167139.1
      Conserved Domains (2) summary
      cd14964
      Location:53 → 79
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:42 → 291
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN40.1 GenPept UniProtKB/Swiss-Prot:Q7TN40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials