S100A4 S100 calcium binding protein A4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: S100A4provided by VGNC
Official Full Name: S100 calcium binding protein A4provided by VGNC
Primary source: VGNC:VGNC:45830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: MTS1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	7	NC_051811.1 (43443738..43445759)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	7	NC_006589.4 (42986972..42988993)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	7	NC_049228.1 (43483524..43485545)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	7	NC_049267.1 (43146014..43148039)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	7	NC_049748.1 (43199907..43201928)

Chromosome 7 - NC_051811.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A4 is secreted by airway smooth muscle tissues and activates inflammatory signaling pathways via receptors for advanced glycation end products.
Title: S100A4 is secreted by airway smooth muscle tissues and activates inflammatory signaling pathways via receptors for advanced glycation end products.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RAGE receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein S100-A4

Names: S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); metastasin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003161.3 → NP_001003161.1 protein S100-A4 isoform 1

See identical proteins and their annotated locations for NP_001003161.1

Status: VALIDATED

Description

Transcript Variant: This variant (a, also known as variant 1) encodes isoform 1. Variants a and b both encode the same isoform (1).

Source sequence(s)

JAAUVH010000022

UniProtKB/Swiss-Prot

Q9TV56

UniProtKB/TrEMBL

A0A346JM02, A0A8I3MM14, A0A8P0NIP1

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
NM_001362597.3 → NP_001349526.2 protein S100-A4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (c, also known as variant 3) differs in the 5' UTR and 5' coding region compared to variant a. The encoded isoform (2) has a longer N-terminus than isoform 1.

Source sequence(s)

JAAUVH010000022

UniProtKB/TrEMBL

A0A346JM01, A0A8C0Q2X4

Conserved Domains (1) summary

cd00213
Location:45 → 131

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
NM_001363554.1 → NP_001350483.1 protein S100-A4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (b, also known as variant 4) differs in the 5' UTR compared to variant a, and encodes the same protein (isoform 1).

Source sequence(s)

JAAUVH010000022

UniProtKB/Swiss-Prot

Q9TV56

UniProtKB/TrEMBL

A0A346JM02, A0A8I3MM14, A0A8P0NIP1

Conserved Domains (1) summary

cd00213
Location:4 → 90

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...