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    ZKSCAN2 zinc finger with KRAB and SCAN domains 2 [ Homo sapiens (human) ]

    Gene ID: 342357, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZKSCAN2provided by HGNC
    Official Full Name
    zinc finger with KRAB and SCAN domains 2provided by HGNC
    Primary source
    HGNC:HGNC:25677
    See related
    Ensembl:ENSG00000155592 AllianceGenome:HGNC:25677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF694; ZSCAN31; ZSCAN34
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 3.7), ovary (RPKM 2.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZKSCAN2 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (25236001..25257845, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (25515492..25537336, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (25247322..25269166, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 557, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10606 Neighboring gene aquaporin 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25268532-25269092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10608 Neighboring gene ZKSCAN2 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr16:25422594-25423095 Neighboring gene long intergenic non-protein coding RNA 2191 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:25453167-25454366 Neighboring gene CYCS pseudogene 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. Kamran M, et al. Oncogenesis, 2017 Feb 20. PMID 28218735, Free PMC Article
    2. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
    3. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
    4. Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Bartolec TK, et al. Proc Natl Acad Sci U S A, 2023 Apr 25. PMID 37071682, Free PMC Article
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23199

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein with KRAB and SCAN domains 2
    Names
    zinc finger and SCAN domain containing 31
    zinc finger protein 694

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012981.5 → NP_001012999.3  zinc finger protein with KRAB and SCAN domains 2

      See identical proteins and their annotated locations for NP_001012999.3

      Status: VALIDATED

      Source sequence(s)
      AC008741, BC130007, BX648785, DB120548
      Consensus CDS
      CCDS32410.1
      UniProtKB/Swiss-Prot
      A1L3B4, Q63HK3, Q6ZN77
      UniProtKB/TrEMBL
      B4E0P9
      Related
      ENSP00000331626.7, ENST00000328086.12
      Conserved Domains (9) summary
      smart00431
      Location:41 → 148
      SCAN; leucine rich region
      cd07765
      Location:227 → 268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:248 → 289
      KRAB; krueppel associated box
      COG5048
      Location:771 → 957
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:777 → 797
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:831 → 853
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:41 → 129
      SCAN; SCAN domain
      pfam13465
      Location:789 → 813
      zf-H2C2_2; Zinc-finger double domain
      pfam13837
      Location:497 → 578
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      25236001..25257845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023200.3 → XP_016878689.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

      UniProtKB/TrEMBL
      B4DYF0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      25515492..25537336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380222.1 → XP_054236197.1  zinc finger protein with KRAB and SCAN domains 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63HK3.2 GenPept UniProtKB/Swiss-Prot:Q63HK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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