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    Mtfmt mitochondrial methionyl-tRNA formyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315763, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Mtfmtprovided by RGD
    Official Full Name
    mitochondrial methionyl-tRNA formyltransferaseprovided by RGD
    Primary source
    RGD:1309462
    See related
    EnsemblRapid:ENSRNOG00000014602 AllianceGenome:RGD:1309462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309462
    Summary
    Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 88.1), Adrenal (RPKM 73.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74848936..74866987)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65953787..65971841)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70952209..70986393)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RAS-like, family 12 Neighboring gene SLC51 subunit beta Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene ankyrin repeat and death domain containing 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95129

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables methionyl-tRNA formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionyl-tRNA formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionyl-tRNA formyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methionyl-tRNA formyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methionyl-tRNA formyltransferase, mitochondrial
    NP_001009697.1
    XP_038937434.1
    XP_038937435.1
    XP_063121592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009697.1 → NP_001009697.1  methionyl-tRNA formyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_001009697.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088470
      UniProtKB/Swiss-Prot
      Q5I0C5
      UniProtKB/TrEMBL
      A0A8L2QA74, A6J5F4
      Related
      ENSRNOP00000019671.4, ENSRNOT00000019671.7
      Conserved Domains (1) summary
      TIGR00460
      Location:44 → 353
      fmt; methionyl-tRNA formyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      74848936..74866987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265522.1 → XP_063121592.1  methionyl-tRNA formyltransferase, mitochondrial isoform X2

    2. XM_039081506.1 → XP_038937434.1  methionyl-tRNA formyltransferase, mitochondrial isoform X1

      Conserved Domains (1) summary
      TIGR00460
      Location:9 → 226
      fmt; methionyl-tRNA formyltransferase

    3. XM_039081507.2 → XP_038937435.1  methionyl-tRNA formyltransferase, mitochondrial isoform X3

      Conserved Domains (2) summary
      COG0223
      Location:6 → 175
      Fmt; Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]
      cl00395
      Location:6 → 70
      FMT_core; Formyltransferase, catalytic core domain

    RNA

    1. XR_005487822.2 RNA Sequence

    2. XR_005487823.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0C5.1 GenPept UniProtKB/Swiss-Prot:Q5I0C5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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